Journal of Bioprocessing & Biotechniques

Uttiya Basu

Uttiya Basu, Ph.D
Assistant Professor, Department of Microbiology and Immunology
University College of Physicians and Surgeons, USA

Biography

Dr. Uttiya Basu did his doctoral training in molecular biology and biochemistry at the Albert Einstein College of Medicine, New York. Thereafter he did his post-doctoral training in Immunology as a Irvington Institute Fellow at Harvard School of Medicine, Boston.  At present he is a assistant professor in immunology at the Department of Microbiology and Immunology, Columbia University, New York. He is a fellow of the Leukemia and Lymphoma Society of America, Irma Hirschl Foundation and Leukemia Research Foundation.

Research Interest

Antibodies are polypeptide complexes produced by B-lymphocytes of the immune system that identify and neutralize pathogens, such as bacteria and viruses. Antibodies are comprised of immunoglobulin (Ig) heavy (IgH) and light (IgL) chain polypeptides. Each polypeptide has an N-terminal variable region that facilitates its binding to antigen, whereas the C-terminal constant region of the IgH chain is necessary for downstream effector functions. There are three DNA alteration events that allow mammalian B lymphocytes to achieve enormous antibody diversification: V(D)J recombination, class switch recombination and somatic hypermutation. Developing B cells, in the bone marrow, undergo V(D)J recombination to assemble exons encoding the IgH and IgL variable (V) regions upstream of the corresponding constant region exons.