Mohamad Sawan
Epilepsy Journal (ELJ), a broad-based journal was founded on two key tenets: To publish the most exciting researches with respect to the subjects of Brain Epilepsy. Secondly, to provide a rapid turn-around time possible for reviewing and publishing and to disseminate the articles freely for research, teaching and reference purposes.
Lan Xiong
Without continual growth and progress, such words as improvement, achievement, and success have no meaning. Epilepsy Journal (ISSN: 2472-0895) is growing continuously. It is our pleasure to announce that during year 2020, all issues of volume 6 were published online on time and the print issues were also brought out and dispatched within 30 days of publishing the issue online.
Joy Benicio
People with epilepsy could also be classified into different syndromes supported specific clinical features. These features include the age at which seizures begin, the seizure types, and EEG findings, among others. Identifying an epilepsy syndrome is beneficial because it helps determine the underlying causes also as deciding what anti-seizure medication should be tried. Epilepsy syndromes are more commonly diagnosed in infants and youngsters. Some samples of epilepsy syndromes include benign rolandic epilepsy (2.8 per 100,000), childhood absence epilepsy (0.8 per 100,000) and juvenile myoclonic epilepsy (0.7 per 100,000).[3] Severe syndromes with diffuse brain dysfunction caused, a minimum of partly, by some aspect of epilepsy, also are mentioned as epileptic encephalopathies. These are related to frequent seizures that are immune to treatment and severe cognitive dysfunction, as an example Lennox-Gastaut syndrome and West syndrome.
Grey Zyaire
Photosensitive epilepsy (PSE) may be a sort of epilepsy during which seizures are triggered by visual stimuli that form patterns in time or space, like flashing lights; bold, regular patterns; or regular moving patterns.
PSE affects approximately one in 4,000 people (5% of these with epilepsy).
Sylvie joelle
Benign Rolandic epilepsy or benign childhood epilepsy with centrotemporal spikes (BCECTS) is that the most typical epilepsy
Syndrome in childhood. Most kids will outgrow the syndrome (it starts around the age of 3–13 with a peak around 8–9 years and stops around age 14–18), hence the label benign. The seizures, sometimes mentioned as sylvian seizures, start around the fissure of Rolando of the brain (also called the centrotemporal area, located around the Rolandic fissure, after Luigi Rolando)
DOI: 10.37421/2472-0895.2023.9.186
Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions of individuals worldwide. While medication remains the primary treatment option, a significant proportion of patients experience inadequate seizure control or intolerable side effects. In recent years, non-invasive brain stimulation techniques have gained attention as potential adjunctive therapies for epilepsy. These techniques aim to modulate brain activity and disrupt seizure activity through targeted stimulation. This article provides an overview of the recent advances in non-invasive brain stimulation techniques, including Transcranial Magnetic Stimulation (TMS) and transcranial electrical stimulation (TES), and their potential as innovative approaches in the management of epilepsy.
Adama Koundoul*, Thiam L and Kane Y
DOI: 10.37421/2472-0895.2024.10.256
DOI: 10.37421/2472-0895.2024.10.257
Epilepsy, a neurological disorder characterized by recurrent seizures, affects millions of people worldwide. While its primary symptoms are related to seizure activity, epilepsy is frequently accompanied by a range of psychiatric disorders. Understanding the intricate relationship between epilepsy and comorbid psychiatric conditions is essential for effective treatment and improved quality of life for patients. While the primary focus of epilepsy management often revolves around controlling seizures, it is crucial to recognize that many individuals with epilepsy also experience psychiatric disorders. These comorbid psychiatric conditions can significantly impact the patient's overall well-being and complicate epilepsy management. The relationship between epilepsy and psychiatric disorders is bidirectional, meaning that individuals with epilepsy are at an increased risk of developing psychiatric conditions and conversely, psychiatric disorders can influence the course and management of epilepsy. Common psychiatric comorbidities include anxiety disorders, depression and psychosis.
DOI: 10.37421/2472-0895.2024.10.258
Epilepsy, a neurological disorder characterized by recurrent seizures, affects approximately 50 million people worldwide. Historically, the management of epilepsy has relied on a one-size-fits-all approach, with antiepileptic drugs (AEDs) prescribed based on general seizure type and broad patient characteristics. However, recent advancements in personalized medicine are revolutionizing this paradigm by tailoring treatments to individual genotypes, offering the promise of more effective and precise management for patients. Antiepileptic Drugs (AEDs), also known as anticonvulsants, are medications used to manage and prevent seizures in individuals with epilepsy. Epilepsy is a neurological disorder characterized by recurrent seizures, which can vary widely in type and severity. AEDs aim to control these seizures, improve the quality of life and reduce the frequency and intensity of epileptic episodes.
DOI: 10.37421/2472-0895.2024.10.259
Epilepsy, a chronic neurological disorder characterized by recurrent seizures, affects approximately 50 million people worldwide. While traditional antiepileptic drugs have made significant strides in managing this condition, there is an ongoing need for novel treatments that offer improved efficacy, fewer side effects and enhanced quality of life for patients. Recent advancements in drug development have led to the emergence of several new AEDs, which have been evaluated in recent clinical trials. Antiepileptic drugs are pivotal in managing epilepsy, a neurological disorder marked by recurrent seizures. Despite the efficacy of established AEDs, the search for new drugs continues due to limitations like insufficient efficacy in refractory cases, adverse side effects and individual variability in drug responses. The advent of novel AEDs reflects advances in our understanding of epilepsy's pathophysiology and pharmacology, aiming to offer improved outcomes.
DOI: 10.37421/2472-0895.2024.10.260
Epilepsy is a complex neurological disorder characterized by recurrent, unprovoked seizures. Affecting approximately 1 in 26 people over their lifetime, its management and treatment have historically been challenging, particularly due to the heterogeneous nature of the condition. Its underlying causes are multifaceted, but genetic factors play a pivotal role in many cases. Understanding the genetic basis of epilepsy has been transformative, shedding light on its pathophysiology and leading to more personalized treatment approaches. However, recent advances in genetics have provided profound insights into the molecular underpinnings of epilepsy, leading to the identification of key genetic mutations that have significant implications for treatment and personalized medicine.
DOI: 10.37421/2472-0895.2024.10.261
DOI: 10.37421/2472-0895.2024.10.262
DOI: 10.37421/2472-0895.2024.10.263
DOI: 10.37421/2472-0895.2024.10.264
DOI: 10.37421/2472-0895.2024.10.265
DOI: 10.37421/2472-0895.2023.9.206
This study investigates the intricate relationship between neuroanatomy, neurophysiology, and turning performance in individuals diagnosed with Multiple Sclerosis (MS). Multiple Sclerosis is a complex neurological disorder characterized by demyelination and neuroinflammation, leading to a wide range of motor and sensory impairments. Understanding how specific neuroanatomical and neurophysiological factors influence turning ability is crucial for optimizing rehabilitation strategies and enhancing the quality of life for individuals with MS. Through advanced imaging techniques, neurophysiological assessments, and kinematic analyses, this research aims to uncover the underlying mechanisms that contribute to turning deficits in MS patients. The findings from this study will provide valuable insights into personalized treatment approaches and interventions for improving mobility and functional independence in this population.
DOI: 10.37421/2472-0895.2023.9.207
Deep-sea oceanauts operate in challenging and high-stress environments where cognitive workload plays a pivotal role in task performance and safety. This study aims to analyze mental workload among deep-sea oceanauts during driving operation tasks using Electroencephalogram (EEG) data. We collected EEG data from oceanauts engaged in simulated driving tasks in a submersible vehicle, assessing cognitive workload through neural markers. Our findings reveal distinct patterns of mental workload across different phases of the driving operation, shedding light on the cognitive demands and potential stressors faced by oceanauts in these conditions. This research contributes to enhancing safety and performance optimization for deep-sea missions.
DOI: 10.37421/2472-0895.2023.9.208
This study aimed to isolate and characterize bacteriocin-producing Lactic Acid Bacteria (LAB) from the intestinal microbiota of Gilthead Seabream (Sparus aurata) and Whiting Fish (Merlangius merlangus). LAB are known for their potential as probiotics and natural preservatives due to their ability to produce antimicrobial peptides known as bacteriocins. In this research, LAB strains were isolated, identified, and their bacteriocin production assessed. Additionally, the inhibitory spectrum and safety profiles of the bacteriocins were investigated. The results provide valuable insights into the potential use of LAB-derived bacteriocins in aquaculture and food preservation.
DOI: 10.37421/2472-0895.2023.9.209
This study presents advancements in the functionality and characterization of an electrophysiological mapping electrode probe equipped with directional carbonic macrocontacts. The probe's enhanced design and improved performance make it a valuable tool for precise neural recording and mapping applications. We discuss the methodology employed for the functional enhancements, provide a detailed characterization of the probe's capabilities, and highlight its potential contributions to neuroscientific research.
DOI: 10.37421/2472-0895.2023.9.210
This study investigates the immediate effects of a single session of OnabotulinumtoxinA therapy on sleep quality and psychological measures in patients suffering from chronic migraine. Chronic migraine is a debilitating condition characterized by frequent and severe headache attacks, often leading to disrupted sleep patterns and adverse psychological well-being. While OnabotulinumtoxinA has shown efficacy in reducing migraine frequency and severity, its impact on sleep quality and psychological parameters remains underexplored. In this preliminary study, a cohort of chronic migraine patients received a single OnabotulinumtoxinA therapy session. Sleep quality was assessed using validated sleep questionnaires, and psychological measures, including anxiety and depression levels, were evaluated through standardized psychological assessments. Baseline measures were compared with post-treatment data to determine the immediate impact of OnabotulinumtoxinA on sleep quality and psychological well-being. Preliminary findings indicate a significant improvement in sleep quality within hours of OnabotulinumtoxinA administration, suggesting its potential role in alleviating sleep disturbances associated with chronic migraine. Furthermore, there was a notable reduction in anxiety and depression scores, highlighting the therapeutic potential of OnabotulinumtoxinA in addressing the psychological burden of chronic migraine patients. These preliminary findings suggest that a single OnabotulinumtoxinA therapy session may have a rapid and positive impact on sleep quality and psychological well-being in chronic migraine patients. Further research is warranted to confirm and expand upon these initial observations and explore the long-term effects of OnabotulinumtoxinA therapy on these parameters.
DOI: 10.37421/2472-0895.2023.9.211
This study investigates the intricate relationship between brain dopamine-clock interactions and their impact on cardiometabolic physiology, with a particular focus on elucidating the mechanisms underlying the observed cardioprotective effects of circadian-timed Bromocriptine-QR therapy in individuals with Type 2 Diabetes. The circadian rhythm plays a pivotal role in regulating various physiological processes, including metabolism and cardiovascular health. Through a comprehensive analysis of the interplay between brain dopamine pathways and the circadian clock, we aim to provide insights into the therapeutic potential of timing medication administration to align with the body's natural rhythms. Our findings shed light on the intricate web of molecular and physiological mechanisms governing this interaction, offering new perspectives for optimizing treatment strategies in Type 2 Diabetes management while promoting cardiovascular health.
DOI: 10.37421/2472-0895.2023.9.212
This study presents a novel Mobile Electroencephalography (EEG) system and evaluates its performance in comparison to conventional clinical EEG. The mobile EEG system offers an innovative approach to EEG monitoring, providing potential benefits in terms of portability and ease of use. In this research, we conducted a comprehensive assessment of the mobile EEG system's quality, examining its accuracy and reliability when compared to traditional clinical EEG recordings. Our findings highlight the potential utility of the mobile EEG system as a valuable tool for noninvasive brain activity monitoring in various clinical and research settings.
DOI: 10.37421/2472-0895.2023.9.213
This study explores the neurophysiological implications of motor threshold variability observed during transcranial magnetic stimulation treatment for depression. TMS is a promising therapeutic approach, but its effectiveness may be influenced by variations in motor threshold across individuals. We investigated the potential impact of these threshold fluctuations on treatment outcomes, shedding light on the neurophysiological mechanisms at play. Our findings provide insights into the optimization of TMS protocols for more effective depression management.
DOI: 10.37421/2472-0895.2023.9.214
This study delves into the dynamic aspects of human neurophysiological responses during an authentic olfactory experience in a naturalistic setting. The research explores the temporal dimensions of neurophysiological activities as individuals engage with ecological odors. Through the use of advanced monitoring techniques, we examine how these responses evolve over time, shedding light on the intricate interplay between the olfactory system and human cognition in real-world scenarios. This investigation contributes valuable insights into the temporal dynamics of sensory perception and its implications for our understanding of human brain function in ecologically relevant contexts.
DOI: 10.37421/2472-0895.2023.9.215
This study explores the potential utility of nutritional interventions in the management of chronic mild traumatic brain injury, concussion, and sportsrelated concussion. We delve into the emerging evidence suggesting that nutrition may play a crucial role in the recovery and long-term outcomes of individuals affected by these conditions. The review encompasses various aspects of nutrition, including dietary components, supplements, and dietary patterns, and their impact on brain health, cognitive function, and symptom management in the chronic phase of mTBI and concussion. We analyze recent research findings, highlighting the need for further investigations to elucidate the specific mechanisms underlying the observed effects. The insights presented in this review underscore the promising avenues for incorporating nutrition into the comprehensive care strategies for individuals with chronic mTBI, concussion, and SRC.
DOI: 10.37421/2472-0895.2024.10.236
DOI: 10.37421/2472-0895.2024.10.237
Epilepsy is a complex neurological disorder characterized by recurrent seizures, affecting millions of people worldwide. While epilepsy manifests in various forms and severity levels, it's crucial to understand the spectrum of syndromes it encompasses. From benign to severe, epilepsy syndromes offer insights into the diverse clinical presentations, underlying mechanisms and treatment strategies. Epilepsy syndromes refer to a group of disorders defined by specific clinical features, seizure types, age of onset, EEG findings and underlying etiologies. These syndromes provide clinicians with valuable information for accurate diagnosis, prognosis and treatment planning. While over forty epilepsy syndromes have been identified, they can be broadly categorized into focal (partial) and generalized epilepsies. Focal epilepsies, also known as partial epilepsies, originate from a localized area of the brain and may involve specific symptoms or behaviors depending on the brain region affected. These seizures can be further classified into simple partial seizures, complex partial seizures and secondary generalized seizures.
DOI: 10.37421/2472-0895.2024.10.238
DOI: 10.37421/2472-0895.2024.10.239
DOI: 10.37421/2472-0895.2024.10.240
Childhood is often portrayed as a time of innocence, exploration and boundless energy. However, for children with epilepsy, this idyllic image can be shattered by the unpredictable and potentially life-altering nature of their condition. Epilepsy, characterized by recurrent seizures, affects individuals of all ages, but its impact on children can be particularly profound. Epilepsy is a neurological disorder marked by abnormal brain activity, leading to seizures. In children, epilepsy can manifest in various forms, from subtle absence seizures to dramatic convulsions. While the exact cause of epilepsy in children is often unknown, it can be attributed to factors such as genetic predisposition, brain injuries, infections, or developmental disorders. One of the challenges in diagnosing childhood epilepsy is recognizing the symptoms, as they may be mistaken for other conditions or developmental quirks. For example, absence seizures, which cause brief lapses in awareness, may be misconstrued as daydreaming or inattention. On the other hand, convulsive seizures, characterized by uncontrolled jerking movements, are more readily identifiable but can be terrifying for both the child experiencing them and those witnessing the episode.
DOI: 10.37421/2472-0895.2024.10.241
DOI: 10.37421/2472-0895.2024.10.242
Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions of people worldwide. Despite significant advancements in understanding and treatment, navigating the complexities of epilepsy diagnosis and management remains challenging for healthcare providers and patients alike. From the intricacies of accurate diagnosis to the nuances of personalized treatment plans, addressing epilepsy requires a comprehensive approach. Epilepsy is a diverse spectrum of disorders, encompassing various seizure types, etiologies and clinical presentations. Seizures occur due to abnormal electrical activity in the brain, leading to transient disruptions in normal brain function. These manifestations can range from subtle sensory experiences to convulsions and loss of consciousness. Accurate diagnosis is fundamental for effective management. The International League Against Epilepsy (ILAE) provides a classification system based on seizure type, epileptic syndrome and underlying cause, aiding clinicians in categorizing and treating epilepsy patients effectively.
DOI: 10.37421/2472-0895.2024.10.243
DOI: 10.37421/2472-0895.2024.10.244
The brain, an intricate network of billions of neurons, orchestrates the symphony of our thoughts, emotions and actions. However, this delicate balance can be disrupted by various neurological disorders, among which epilepsy stands out prominently. Epilepsy, a chronic disorder characterized by recurrent seizures, affects millions worldwide, impacting individuals' quality of life and posing significant challenges for both patients and caregivers. Within the spectrum of epilepsy, Temporal Lobe Epilepsy (TLE) holds a unique position, often presenting with complex symptoms and therapeutic considerations. Temporal Lobe Epilepsy refers to a subtype of focal epilepsy characterized by seizures originating in the temporal lobes of the brain. The temporal lobes, nestled on either side of the brain, play pivotal roles in memory formation, language processing, emotion regulation and sensory integration. Consequently, seizures arising from this region can manifest in diverse ways, ranging from altered consciousness and unusual behaviors to complex sensory experiences.
DOI: 10.37421/2472-0895.2024.10.245
DOI: 10.37421/2472-0895.2024.10.246
DOI: 10.37421/2472-0895.2024.10.247
DOI: 10.37421/2472-0895.2024.10.248
DOI: 10.37421/2472-0895.2024.10.249
DOI: 10.37421/2472-0895.2024.10.250
DOI: 10.37421/2472-0895.2024.10.251
Epilepsy, a neurological disorder characterized by recurrent seizures, has challenged medical science for centuries. The unpredictability and often devastating impact of seizures on individuals’ lives have spurred researchers and clinicians to explore innovative treatments. Over the years, significant progress has been made in understanding epilepsy and developing effective interventions, offering hope and improved quality of life for millions worldwide. Historically, epilepsy treatment primarily revolved around managing symptoms through medication. While Antiepileptic Drugs (AEDs) have been instrumental in controlling seizures for many, they are not universally effective and often come with side effects that can be burdensome for patients. However, recent decades have witnessed a revolution in epilepsy management, with breakthroughs in various therapeutic modalities.
DOI: 10.37421/2472-0895.2024.10.252
Living with epilepsy presents unique challenges, but with the right strategies, individuals can effectively manage seizures and enhance their quality of life. Epilepsy, a neurological disorder characterized by recurrent seizures, affects millions of people worldwide, regardless of age, gender, or background. While there is no cure for epilepsy, there are numerous ways to cope with the condition and reduce its impact on daily life. Epilepsy is a neurological disorder characterized by recurrent, unpredictable seizures. These seizures result from abnormal electrical activity in the brain, leading to temporary disruptions in normal brain function. While epilepsy can affect individuals of any age, from infants to older adults, it often develops during childhood or adolescence.
DOI: 10.37421/2472-0895.2024.10.253
Epilepsy, a neurological disorder characterized by recurrent seizures, affects millions worldwide. Despite significant progress in understanding and managing the condition, many individuals still face challenges in finding effective treatments. However, recent advancements in epilepsy research offer promising breakthroughs that could revolutionize the way we diagnose and treat this complex disorder. One of the most exciting developments in epilepsy research is the move towards precision medicine. Traditionally, epilepsy treatment has followed a one-size-fitsall approach, often relying on a trial-and-error method to find the right medication for each patient. However, researchers are now exploring personalized treatment strategies based on a patient's genetic makeup, brain imaging data and other biomarkers. Recent studies have identified specific genetic mutations associated with epilepsy, paving the way for targeted therapies.
DOI: 10.37421/2472-0895.2024.10.254
DOI: 10.37421/2472-0895.2024.10.255
Epilepsy, a neurological disorder characterized by unpredictable seizures, has long been intertwined with various facets of mental health. This intricate relationship between epilepsy and mental well-being is multifaceted, impacting individuals in profound ways beyond the seizures themselves. Understanding this connection is crucial for comprehensive patient care and support. Epilepsy and mental health disorders often coexist, creating a complex interplay of symptoms and challenges. Research indicates that individuals with epilepsy are at a higher risk of experiencing mental health issues compared to the general population. Depression, anxiety and cognitive impairment are among the most prevalent mental health concerns in this demographic.
Yongxiang Zou, Jingbin Liu, Qi Wang, Keshuai Zhang, Jing Sun, Junliang Zhang, Cheng Peng, Qi Li and Zhongmin Yin*
DOI: 10.37421/2472-0895.2024.10.266
Objective: To compare the effects of different surgical strategies in patients with various types of epilepsy accompanying mental symptoms.
Methods: The clinical and follow-up data of 65 patients with epilepsy accompanying mental symptoms admitted to our department from January 2014 to December 2016 were retrospectively analyzed. Patients were categorized into two types using self-made evaluation scales based on the degree of correlation between their mental symptoms and seizures. Type I (n=28) exhibited a high correlation and was treated with a combined craniotomy, while Type II (n=37), characterized by a low correlation, underwent treatment using multi-target stereotactic radiofrequency thermocoagulation.
Results: (1) the ORR was 90.77%, while the RR was 89.29% and 91.89% in type Ⅰ and type Ⅱ patients, respectively; (2) the ORR for epilepsy treatment was 86.15%, the RR was 89.29% and 83.78% in patients of type Ⅰ and Ⅱ respectively; (3) the total scores significantly decreased in BPRS, SAPS and SANS after surgery and there were significant statistical differences compared with those before surgery (P<0.05).
Conclusion: (1) Active surgical treatment significantly reduces the frequency of epileptic seizures, alleviates mental symptoms and improves quality of life for patients with epilepsy accompanying mental symptoms; (2) The self-made evaluation scale contributes to selecting the appropriate surgical method and predicts a favorable prognosis.
DOI: 10.37421/2472-0895.2024.10.267
DOI: 10.37421/2472-0895.2024.10.268
DOI: 10.37421/2472-0895.2024.10.269
DOI: 10.37421/2472-0895.2024.10.270
DOI: 10.37421/2472-0895.2024.10.271
DOI: 10.37421/2472-0895.2024.10.272
DOI: 10.37421/2472-0895.2024.10.273
DOI: 10.37421/2472-0895.2024.10.274
DOI: 10.37421/2472-0895.2024.10.275
Epilepsy Journal received 41 citations as per Google Scholar report
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 