Nelly Adel
Osman Adiguzel
Nelly Adel
Smith Amelia
“The Scientific Service Achievement Award will be presented individuals to recognize and honour in the field of Pharmacology and Toxicology who have established exceptional guidance and made significant contributions through their career achievements and support in the areas of Pharmacy including training, mentoring and international impact.
Indu Thakur
“Mass Spectrometry 2020 will inspire scientists and researchers & young researchers in their early level of career graph to widely discuss their outcome in order to enrich and expand the idea by felicitating them with the various Awards in their respective fields. The Main aim is meant to encourage students in taking active part in the International Science platform to sharpen their skills and knowledge
Dragan Nikolic
“Following the great success of World Congress on Diabetes and Endocrinology meeting in Rome and along with encouragement from participants, Pulsus Group is to organize the “2nd World Congress on Diabetes and Endocrinology (WDEC 2020)” which is the world’s leading diabetologists and endocrinologists meet organized on May 1314, 2020 at Edinburgh, Scotland
Emmanuel Andres
In contrast with drugs, there are huge contrasts in dietary enhancements that sway the assessment of their bioavailability. These distinctions incorporate the accompanying: the way that dietary enhancements give benefits that are variable and frequently subjective in nature; the estimation of supplement retention comes up short on the exactness; healthful enhancements are burned-through for anticipation and prosperity; nourishing enhancements don't show trademark portion reaction bends; and dosing time frames supplements, accordingly, are not basic as opposed to medicate therapy.
Jason Haxton
Logical science studies and uses instruments and strategies used to isolate, recognize, and measure matter by and by, partition, distinguishing proof or evaluation may establish the whole examination or be joined with another strategy. Partition secludes analytes. Subjective examination recognizes analytes, while quantitative investigation decides the mathematical sum or focus.
Ashish Dhawad
Amelia Flora
Li-Pin Kao
Adalbertoi Pessoa
Stephen T.Arbedon
Marvin Koon
Gery Rifano
Tarek Motawi
Pawan Saharan
Gerald Tan
Wen-Cai Ye
In microbiology, the minimum inhibitory concentration is the lowest concentration of a chemical, usually a drug, which prevents visible growth of a bacterium or bacteria. MIC depends on the microorganism, the affected human being and the antibiotic itself. It is often expressed in micrograms per milliliter or milligrams per literThe MIC is determined by preparing solutions of the chemical in vitro at increasing concentrations, incubating the solutions with separate batches of cultured bacteria, and measuring the results using agar dilution or broth micro dilution. Results have been graded into susceptible often called sensitive increased exposure or resistant to a particular antimicrobial by using a breakpoint. Breakpoints are agreed upon values, published in guidelines of a reference body.
Arnod R Kriegstein
Prior to antibiotics, bacterial infections along with pneumonia, gonorrhea, and syphilis killed tens of thousands and testing in to your in human beings every year. Periodical outbreaks of bacterial ailment crammed hospitals and clinics, and with certainly no powerful scientific treatments to be had, Infections uses sufferers servere of the to immensely. Eventually, researchers located that positive chemical compounds may want to kill off or save you the increase of bacteria, and these days we own greater than 20 training of antibiotics composed cases dozens of commercially to be had drugs. The first proper antibiotic, penicillin, become located to 1928 with the intial to of using Alexander Fleming, and although over.
Arnod R Kriegstein
Nanotechnology, additionally abbreviated to nanotech, is the utilization of issue scale for modern purposes. The soonest, boundless depiction of nanotechnology alluded to the specific innovative objective of correctly controlling particles and atoms for manufacture of macroscale items, materials and scope of harmfulenss as sub-atomic nanotechnology. A more summed up portrayal of nanotechnology was in this way settled by the National Nanotechnology Initiative, which characterized nanotechnology as the control of issue with no less than one measurement estimated from 1 to 100 nanometers. This definition mirrors the way that quantum mechanical impacts are significant at this quantum-domain scale, thus the definition moved from a specific innovative objective to an examination classification comprehensive.
Stephen M Campbell, Johanna C Meyer and Brian Godman*
There are concerns with high prevalence rates for both infectious and non-infectious disease in Sub-Saharan Africa, as well as patients with joint co-morbidities. This requires consideration of multiple guidelines simultaneously to improve the care of patients. Adherence to guidelines is increasingly seen as key criteria for assessing the quality of prescribing in ambulatory care versus the WHO/INRUD targets. These typically represent activity (volume) or performance (cost) indicators rather than quality indicators. However, guideline adherence is currently variable across sectors, diseases areas and African countries. Factors impacting on adherence rates include their routine availability, ease of access and referencing, the extent of consensus on their content, extent of training of their use, monitoring of subsequent prescribing against agreed suggestions and whether regularly updated. Multiple initiatives are typically more successful with changing prescribing habits versus single approaches.
Xiang-Hai ai
The second Proteome - Designated Medication Revelation Highest point will join enormous pharma and inventive biotech, just as key assessment pioneers in scholarly world, to foster powerful primary and biochemical instruments to open up the full helpful open door held inside the whole proteome. Recognize and approve novel druggable destinations and enhance structuredirected part based medication plan of little atoms with further developed power, selectivity, and physic-compound properties. With about 85% of the proteome as of now undrugged, getting to these objectives that are, as of now, incredibly hard to tranquilize, has kept analysts from accomplishing wanted clinical victories.
Channa punctatus is fresh water fish. It has pharmaceutical potential to prevent cardiac disorders, skin infections, diabetes etc. By lipid test profile, Analytical method, Chromatography method, Enzyme method, we found in Channa punctatus fatty acid, glycine, lysine, arachidonic acid, DHA, etc. Channa punctatus has be used as biomedical and nutraceutical products.
Shash Zhao
“Pharmacognosy” obtains from two Greek words, “pharmakon” or drug, and “gnosis” or knowledge. Like countless complementing branchs of science, Pharmacognosy has undergone crucial change in recent years and today acts for a highly interdisciplinary science that is one of five major regions of pharmaceutical education.
DOI: 10.37421/jbps.2021.4.e324
DOI: 10.37421/jbps.2022.5.340.
DOI: 10.37421/2952-8100.2023.6.425
The Covid-19 pandemic, responsible for over 6 million worldwide deaths, there was an urgent need for preventative measures to mitigate its effects. Conventional vaccines, which typically prevent or reduce disease severity, usually require more than a decade for development and commercialization. The pressing nature of the pandemic led to the pursuit of novel solutions like mRNA-based vaccines, playing a critical role in saving lives. This article highlights the potential of mRNA technology to go beyond infectious diseases, offering the possibility to change the treatment landscape of future malignant diseases and address unmet medical needs.
DOI: 10.37421/2952-8100.2023.6.426
The COVID-19 pandemic has presented unprecedented challenges to healthcare systems worldwide. In severe cases, the virus can lead to Acute Respiratory Distress Syndrome (ARDS), necessitating advanced interventions such as Extracorporeal Membrane Oxygenation (ECMO). ECMO provides temporary mechanical support to the heart and lungs, allowing them to rest and heal. However, determining the success of ECMO in COVID-19 patients has become a critical concern. Lung ultrasound, a non-invasive imaging technique, has gained traction as a potential tool for predicting the success of ECMO in these patients. This article delves into the application of lung ultrasound in predicting the outcomes of COVID-19 patients undergoing ECMO.
DOI: 10.37421/2952-8100.2023.6.427
The Mediterranean diet, renowned for its health-promoting effects, has long been associated with a reduced risk of cardiovascular and metabolic disorders. In recent years, advancements in multi-omics research have allowed scientists to delve deeper into the intricate mechanisms underlying these benefits. Employing humanized gnotobiotic rats as a model system, this study aims to elucidate the nutritive and oxidative consequences of a Mediterranean diet and oil-based supplements on cardiovascular and metabolic health. By integrating genomics, transcriptomics, proteomics, and metabolomics data, researchers are gaining unprecedented insights into the molecular pathways influenced by dietary interventions. This article reviews the current understanding of the Mediterranean diet, the significance of employing humanized gnotobiotic rats in research, and the insights garnered through multi-omics approaches regarding the diet's impact on cardiovascular and metabolic disorders.
DOI: 10.37421/2952-8100.2023.6.428
Problem-Based Learning (PBL) is a pedagogical approach that has gained significant attention in the field of education, particularly in the context of biomedical science master's courses. It involves presenting learners with real-world, complex problems that drive them to actively engage in problem-solving and critical thinking. As technology continues to shape the educational landscape, the integration of PBL with technological advancements, such as internet-mediated direct contact, has the potential to enhance the learning experience and better address the needs of contemporary learners. This article explores how PBL is employed in biomedical science master's courses, how technological reconstruction facilitates direct contact and synchronization via the internet, and the impact of these changes on the learner's educational experience.
DOI: 10.37421/2952-8100.2023.6.429
Rheumatoid Arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation and damage. Tocilizumab, an interleukin-6 receptor inhibitor, has emerged as a promising treatment for RA. However, concerns exist about its safety and effectiveness in patients undergoing continuous haemodialysis treatment. This clinical report presents a comprehensive analysis of the safety and successful application of Tocilizumab in RA patients on continuous haemodialysis.
DOI: 10.37421/2952-8100.2023.6.430
DOI: 10.37421/2952-8100.2023.6.431
DOI: 10.37421/2952-8100.2023.6.432
DOI: 10.37421/2952-8100.2023.6.434
DOI: 10.37421/2952-8100.2023.6.433
DOI: 10.37421/2952-8100.2024.07.439
Targeted drug delivery systems have emerged as a pivotal strategy in the realm of cancer therapy, offering a potential solution to the challenges posed by traditional treatment modalities. Cancer, a multifaceted disease characterized by uncontrolled cell growth and proliferation, remains a formidable global health concern. Despite significant advancements in oncology research and therapeutic interventions, the efficacy of conventional treatments such as chemotherapy and radiation therapy is often hindered by their lack of specificity, resulting in systemic toxicity and adverse effects on healthy tissues. In response to these limitations, targeted drug delivery systems have garnered increasing attention for their ability to selectively deliver therapeutic agents to cancerous cells while minimizing harm to normal tissues. These systems employ a range of sophisticated strategies, leveraging the unique characteristics of tumors and their microenvironment to achieve precise and efficient drug delivery. Among these strategies, passive and active targeting approaches represent two primary avenues for enhancing drug specificity and efficacy.
DOI: 10.37421/2952-8100.2024.07.438
The development of novel biomaterials for tissue engineering applications in regenerative medicine has emerged as a promising field at the intersection of materials science, biology and medicine. Tissue engineering aims to regenerate, repair, or replace damaged tissues and organs by harnessing the body's natural healing mechanisms combined with engineered biomaterials. This multidisciplinary approach holds significant potential for addressing a wide range of medical conditions, from chronic wounds to organ failure, by providing innovative solutions that mimic the structure and function of native tissues. At the core of tissue engineering is the design and fabrication of biomaterials that can serve as scaffolds to support cell growth, proliferation and differentiation. These scaffolds must possess specific properties to mimic the Extracellular Matrix (ECM) of the target tissue, including appropriate mechanical strength, porosity, surface chemistry and biodegradability. Advances in materials science have enabled the development of biomaterials with tailored properties, allowing researchers to create highly sophisticated scaffolds capable of guiding tissue regeneration with precision.
DOI: 10.37421/2952-8100.2024.07.436
Alzheimer's Disease (AD) remains one of the most challenging and devastating neurodegenerative diseases affecting millions of individuals worldwide. Characterized by progressive cognitive decline, memory loss and eventual impairment in daily activities, AD poses a significant burden on patients, caregivers and healthcare systems. While much research has been devoted to understanding the underlying mechanisms of AD, effective therapeutic interventions that halt or reverse its progression remain elusive. Among the pathological hallmarks of AD are the accumulation of beta-amyloid plaques and the formation of Neurofibrillary Tangles (NFTs) primarily composed of hyperphosphorylated tau protein. While amyloidbeta targeting strategies have been a major focus of drug development, recent attention has shifted towards emerging therapeutic approaches targeting tau pathology.
DOI: 10.37421/2952-8100.2024.07.440
DOI: 10.37421/2952-8100.2024.07.441
DOI: 10.37421/2952-8100.2024.07.442
DOI: 10.37421/2952-8100.2024.07.443
Nanotechnology has emerged as a promising avenue for revolutionizing drug delivery, particularly in enhancing oral bioavailability and achieving controlled release of therapeutic agents. Traditional drug formulations face numerous challenges, including poor solubility, limited stability and inefficient absorption in the gastrointestinal tract, which can significantly affect drug efficacy and patient compliance. Nanotechnology offers innovative solutions by harnessing the unique properties of nanoscale materials to overcome these limitations and improve the pharmacokinetic profiles of orally administered drugs. At the forefront of nanotechnology-based drug formulations are nanoparticles, which are typically in the range of 1-1000 nanometers in size. These nanoparticles can be fabricated from a variety of materials, including polymers, lipids and inorganic compounds, each offering distinct advantages in terms of drug loading capacity, biocompatibility and tunable release kinetics.
DOI: 10.37421/2952-8100.2024.07.445
DOI: 10.37421/2952-8100.2024.07.446
DOI: 10.37421/2952-8100.2024.07.447
DOI: 10.37421/2952-8100.2024.07.449
Drug repurposing, also known as drug repositioning, offers a promising strategy for identifying new therapeutic uses for existing drugs. In the context of rare diseases, where traditional drug discovery approaches face significant challenges, bioinformatics plays a critical role in facilitating the repurposing of drugs to address unmet medical needs. This review examines bioinformatics approaches for drug repurposing in rare diseases, highlighting the methodologies, data sources, and computational tools used to identify potential candidates. By leveraging omics data, network analysis, machine learning, and computational modeling, bioinformatics enables the systematic exploration of drug-disease associations and the prioritization of repurposing candidates based on biological relevance and therapeutic potential. Despite the complexity and heterogeneity of rare diseases, bioinformatics-driven drug repurposing holds promise for accelerating the discovery and development of treatments for these underserved patient populations.
DOI: 10.37421/2952-8100.2024.07.454
Nanotechnology has emerged as a promising approach for improving cancer therapy by enhancing drug delivery precision, reducing systemic toxicity and overcoming drug resistance. In this review, we explore the applications of nanotechnology in targeted drug delivery for cancer therapy. Nanoparticles, liposomes, micelles and other nanostructures offer unique properties, such as tunable size, surface functionalization and sustained release kinetics, which enable targeted delivery of anticancer agents to tumor sites while minimizing off-target effects. By encapsulating drugs within nanocarriers and incorporating targeting ligands, stimuli-responsive materials and imaging agents, nanotechnology facilitates site-specific drug delivery, controlled release and real-time monitoring of therapeutic responses. Despite challenges in clinical translation and scale-up, nanotechnology holds promise for revolutionizing cancer therapy and improving patient outcomes through personalized and precision medicine approaches.
DOI: 10.37421/2952-8100.2024.07.448
DOI: 10.37421/2952-8100.2024.07.450
Multi-drug resistant bacteria pose a significant threat to global public health, rendering many conventional antibiotics ineffective and exacerbating the burden of infectious diseases. The development of novel antibiotic agents capable of overcoming resistance mechanisms is crucial for addressing this challenge. This review explores recent advances in the discovery and development of novel antibiotics to combat multi-drug resistant bacteria. From innovative screening approaches and target identification strategies to the optimization of drug candidates and the exploration of alternative antimicrobial modalities, researchers are employing diverse methodologies to identify new therapeutic options. Despite the complexities and challenges associated with antibiotic development, ongoing efforts hold promise for replenishing the antibiotic pipeline and safeguarding against the growing threat of antimicrobial resistance.
DOI: 10.37421/2952-8100.2024.07.451
DOI: 10.37421/2952-8100.2024.07.452
DOI: 10.37421/2952-8100.2024.07.453
DOI: 10.37421/2952-8100.2024.07.455
DOI: 10.37421/2952-8100.2024.07.456
Epigenetic modifications play a critical role in the development and progression of cancer by regulating gene expression patterns, chromatin structure, and cellular phenotypes. Targeting epigenetic abnormalities has emerged as a promising therapeutic strategy for cancer treatment, offering opportunities to reverse aberrant gene silencing, restore tumor suppressor function, and inhibit oncogenic signaling pathways. In this review, we discuss the challenges and opportunities of targeting epigenetic modifications in cancer therapy. We explore the mechanisms of epigenetic dysregulation in cancer, the therapeutic agents targeting epigenetic enzymes and readers, the clinical applications of epigenetic therapies, and the challenges associated with drug resistance, toxicity, and patient selection. Despite challenges, epigenetic therapies hold promise for improving cancer treatment outcomes and overcoming therapeutic resistance through personalized and precision medicine approaches.
DOI: 10.37421/2952-8100.2024.07.457
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