Jingjing Hu*, Andreas Ciscato and Mojgon Hosseini
DOI: DOI: 10.37421/ 2684-4575.2022.4.3.123
DOI: 10.37421/2684-4575.2023.5.157
The study of specimens plays a pivotal role in various scientific disciplines, from biology and geology to archaeology and materials science. This abstract provides an overview of the significance of specimens in research and the diverse methodologies employed for their collection, preservation and analysis. It discusses how specimens serve as essential tools for advancing knowledge, enhancing our understanding of the natural world and solving complex problems. Additionally, the abstract explores the challenges associated with specimen management, including ethical considerations and the need for sustainable practices. Understanding the value and complexities of specimens is essential for researchers, educators and policymakers to promote responsible specimen stewardship and scientific progress.
DOI: 10.37421/2684-4575.2023.5.163
DOI: 10.37421/2684-4575.2023.5.166
Purvee Agrawal,Arvind Bhake
Background: The recent report in the literatures refers to the role of HPV in pathogenesis of esophageal cancer with geographical biases.
There were not many reports from India where in relationship between HPV and esophageal squamous cell high grade lesions were
analysed. Such studies are required to explore the role of HPV in esophageal Squamous cell carcinoma for its implication of prevention
and treatment.
Aim: The aim of study was to observe the pathogenetic relationship between high grade squamous cell lesion and HPV detected on the tissue
biopsies by immunohistochemistry .The another objective of the study was to study relationship of HPV with grades of SCC.
Methods: Fifty-six paraffin embedded blocks that were diagnosed as high grade squamous cell lesions were selected and the
immunostaining for HPV was performed using mouse monoclonal Anti-Human Papillomavirus (HPV) antibodies (DAKO code M3528)
against HPV.
Results: The study group 56 cases endoscopic biopsies of high grade SCC showed HPV positive IHC staining in total of 12 cases (21.42%) of
which 1 case (1.79%) was of carcinoma in-situ and 11(20%) was of invasive SCC. All the 11 cases of invasive SCC were of well differentiated
SCC which showed positive HPV IHC staining. The p-value for the results of HPV for high grade squamous cell lesions of esophagus was
0.0022 which was significant.
Conclusions: There exist the association between HPV and esophagus high grade squamous cell lesions. These aspects of
pathogenicity are required to be propped further at large sample studies to be carried out in divergent populations.
Keywords: Squamous cell carcinoma • Human papilloma virus • Immunohistochemistry
Doaa Alayed , Assem alroumaih, Ammar cherkess alrikabi
Our case represents a rare and perhaps unique and unusual occurrence of in situ lung adenocarcinoma in a patient who is a known case of tuberous sclerosis. We do not know, yet, if the association of lung adenocarcinoma and tuberous sclerosis is a coincidental finding or there is a casual relationship. However, further studies are warranted to highlight the nature of the linkage between the two conditions.
Journal of Surgical Pathology and Diagnosis received 15 citations as per Google Scholar report
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