Tariere Giwa Osagie*, Tongjura Joseph, Ombugadu Ruth Jamila and Yako Andrew Bmibmitawuza
The fight against malaria is increasingly threatened by failures in vector control due to increasing insecticide resistance. Monitoring and understanding the trend and dynamics of insecticide resistance by the Anopheles mosquito are very essential to devising efficient control strategies. The greatest burden of the disease is felt in Africa, particularly, Nigeria. More information on insecticide resistance is needed in many parts of the country; hence, this study will also contribute to the supply of information in the North-central zone. The study was carried out in 2021, to characterize the mosquito population and its insecticide resistance profile, in their agricultural breeding sites of Karu and Kokona local government areas of Nasarawa state, North-central Nigeria. Mosquito larvae from the breeding sites were sampled and reared to adulthood. The emergent adults were morphologically and molecularly identified to species level. These were An. gambiae, An. coluzzi and An. arabiensis. Susceptibility tests were carried out on the adult mosquitoes using CDC bottle bioassay insecticide discriminating times (in minutes); 12.5 μg for deltamethrin and alpha-cypermethrin, 20 μg for pirimiphos-methyl and 12.5 μg for bendiocarb. The CDC bottle bioassay revealed a graded level of resistance. Knockdown resistant (Kdr)-mutation was detected by PCR, the observation of which implied that selection pressure on the Anopheles population in Karu and Kokona LGAs has occurred. This result is critical for the planning and implementation of malaria vector control interventions based on IRS and ITNs, as currently ongoing in Nigeria.
Malaria Control & Elimination received 1187 citations as per Google Scholar report
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