Kirk Johnson
We are happy to announce the event "International Conference on Pure & Applied Chemistry" scheduled during October 19-20, 2020 at Tokyo, Japan with a theme of “Exploring the Research Challenges and Advancements in Applied Chemistry”. We invite you all to Applied Chemistry 2020 to have incredible associations with the effective professionals.
James Okeya A.I.C Kijabe hospital
The “27th World Congress on Nursing Care” hosted by conference series with the theme, “Advanced Technologies and Best Practices in Nursing & Integrated Care”
Alain L Fymat
The award to the experts who have made outstanding contributions to advancing in Medicinal Chemistry
Kirk Johnson
Chemistry is the branch of Science that is involved in the study of composition, properties and reactivity of matter. Chemistry is called the central science because
Radhey Srivastava
We are proud to present the “12th International Conference on Medicinal Chemistry and Drug Discovery” to be held on October 14-15, 2020 in Munich, Germany, working with the theme: “Unveiling prodigious discoveries and exploratory insights in medicinal chemistry and drug discovery”.
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Natural products have long served as a rich source of lead compounds for drug discovery and development. However, their inherent limitations, such as poor bioavailability, selectivity and metabolic instability, often hinder their clinical utility. Medicinal chemistry strategies play a pivotal role in overcoming these challenges by modifying bioactive natural products to enhance their pharmacological properties. This article provides an overview of various medicinal chemistry approaches employed for the modification of bioactive natural products, including structural optimization, semi-synthesis, prodrug design and molecular hybridization. Case studies highlighting successful examples of these strategies in drug development are also discussed.
DOI: 10.37421/2161-0444.2024.14.715
Immunomodulatory peptides have garnered significant attention in recent years for their dual role as vaccine adjuvants and antimicrobial agents. This article explores the potential of these peptides in enhancing vaccine efficacy and combating microbial infections. We delve into their mechanisms of action, applications in vaccine development and their effectiveness against various pathogens. Furthermore, we discuss the challenges and future prospects of immunomodulatory peptides in the field of immunotherapy and infectious disease management.
DOI: 10.37421/2161-0444.2024.14.714
Metabolomic profiling has emerged as a powerful tool in understanding the molecular intricacies of various diseases, including Endometrial Cancer (EC) and hyperplasia. This article explores recent advancements in metabolomic profiling of blood plasma in females with hyperplasia and EC, highlighting the potential of metabolomics in early detection, prognosis and personalized treatment strategies for these conditions.
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Copper, an essential trace element, plays a pivotal role in various biological processes. However, excess copper levels can lead to cytotoxicity, causing oxidative stress and cell damage. One crucial determinant of copper-induced cytotoxicity is its reduction potential, influencing its redox activity within cells. This article delves into the intricate relationship between copper reduction potential and reductive cytotoxicity, exploring underlying mechanisms, implications for health and potential therapeutic interventions.
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M. Chaitramallu*, G. R. Parvathi, Devaraju Kesagodu and Ranjini
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The aryltetralin derivatives were extracted from plant and also synthesized using tetralone as a starting material. They were synthesized by replacing 1,3-methylene dioxy ring with dimethoxy, hydroxy, methyl, chlorine, hydrogen and methoxy group. The structure of the final compounds was confirmed by 1H NMR, 13C NMR, mass spectra and elemental analysis data and the analogues were screened for anti-diabetic activity. It is noteworthy all the synthesized derivatives exhibits good anti-diabetic activity with respect to extracted aryltetralin compound.
Marcos Aurélio Gomes da Silva*
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The study of molecular pathogenesis provides critical insights into the mechanisms underlying various diseases, facilitating the development of targeted therapies. This review explores the intricate cellular and molecular pathways implicated in disease progression, emphasizing genetic mutations, epigenetic alterations and dysregulated signaling networks. Recent advances in high-throughput sequencing, proteomics and bioinformatics have uncovered novel biomarkers and therapeutic targets. Emerging therapeutic approaches, including gene editing, RNA-based therapies and personalized medicine, hold promise for improving disease management and patient outcomes. This review highlights key mechanistic insights and discusses the potential of innovative treatments to transform the landscape of modern medicine.
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In the quest for novel pharmacological agents with diverse therapeutic applications, the exploration of heterocyclic compounds remains pivotal. Among these, the class of 5-Arylidene(chromenyl-methylene)-thiazolidinediones has emerged as a promising avenue, showcasing intriguing synthesis methodologies, structural diversity and notable biological activities. This article delves into the synthesis strategies, structural elucidation and the multifaceted biological potentials of these compounds, shedding light on their significance in contemporary drug discovery endeavors.
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Phenotypic drug discovery has emerged as a promising approach to identify novel therapeutics by focusing on the functional outcomes of drug action rather than specific molecular targets. This abstract explores the rationale behind phenotypic screening, highlighting its advantages in uncovering complex mechanisms of action, identifying unexpected targets and mitigating issues of target validation. Furthermore, it discusses recent advancements in phenotypic screening technologies, including high-throughput assays and computational approaches, which have accelerated the discovery of diverse compounds with therapeutic potential. By embracing phenotypic drug discovery, researchers can harness the complexity of biological systems to develop innovative treatments for a wide range of diseases, ultimately paving the way for next-generation therapeutics.
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The escalating prevalence of multiple drug resistance poses a formidable challenge to global health. This paper explores strategies and solutions to confront this urgent issue. Through a comprehensive review of literature and case studies, we identify key factors contributing to the emergence and spread of multidrug-resistant pathogens. Additionally, we discuss various approaches including antimicrobial stewardship, infection control measures, development of novel therapeutics and advancements in diagnostic techniques. Moreover, we highlight the importance of interdisciplinary collaboration, public awareness campaigns and policy interventions in mitigating the spread of drug resistance. By implementing multifaceted strategies and fostering global cooperation, we can effectively combat the rise of multiple drug resistance and safeguard public health.
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Endolichenic fungi, a relatively less explored group of microorganisms residing within lichens, have recently garnered attention for their potential in producing bioactive natural molecules with medicinal properties. This article delves into the fascinating world of endolichenic fungi, exploring their habitats, diversity, symbiotic relationships and their significance in drug discovery. Furthermore, it discusses the methodologies employed in isolating and characterizing bioactive compounds from endolichenic fungi and highlights recent advancements in this field. Finally, it emphasizes the future prospects and challenges in harnessing endolichenic fungi as a valuable resource for discovering novel pharmaceuticals.
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Synthetic medicinal chemistry represents a dynamic field at the interface of chemistry and biology, dedicated to the design, synthesis, and optimization of bioactive compounds for therapeutic purposes. This article provides an overview of recent advancements in synthetic methodologies and their applications in drug discovery and development. From innovative synthetic routes to the design of targeted therapeutics, the integration of synthetic chemistry into medicinal research has enabled the creation of novel treatments for various diseases. By bridging the gap between bench science and clinical practice, synthetic medicinal chemistry continues to drive innovation in healthcare.
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In the realm of medicinal chemistry, the quest for novel therapeutic agents propels researchers to continually explore innovative synthetic routes. This article delves into the exploration of new synthetic methodologies in medicinal chemistry, aiming to enhance the efficiency and diversity of compound synthesis for drug discovery and development. Through a comprehensive review of recent literature, this work highlights the advancements in synthetic routes, their applications in medicinal chemistry, and the implications for drug design. By harnessing cutting-edge synthetic strategies, researchers can expand the chemical space and accelerate the discovery of next-generation therapeutics.
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The Role of Synthetic Medicinal Chemistry explores the pivotal role that synthetic chemistry plays in the development of therapeutic interventions for various diseases. This article provides an in-depth analysis of recent advancements in synthetic methodologies and their applications in drug discovery and development. By elucidating the molecular mechanisms underlying disease pathology and leveraging innovative synthetic strategies, researchers can design and synthesize novel compounds with enhanced therapeutic efficacy and selectivity. Through a comprehensive review of the literature, this work highlights the significant contributions of synthetic medicinal chemistry to the fight against disease and outlines future directions for research in this critical field.
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Synthetic Chemistry's Contributions to Healthcare delves into the pivotal role of synthetic chemistry in transforming the landscape of healthcare through the development of innovative therapeutic interventions. This article provides an in-depth exploration of the advancements in synthetic methodologies and their applications in drug discovery and development. By elucidating the molecular mechanisms underlying disease pathogenesis and leveraging cutting-edge synthetic strategies, researchers can design and synthesize novel compounds with enhanced therapeutic efficacy and selectivity. Through an extensive review of the literature, this work highlights the significant contributions of synthetic chemistry to the advancement of medical science and the improvement of patient outcomes.
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Medicinal Chemistry received 6627 citations as per Google Scholar report
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