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Anti Neutrophilic Cytoplasmic Antibody | Open Access Journals
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Alternative & Integrative Medicine

ISSN: 2327-5162

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Anti Neutrophilic Cytoplasmic Antibody

Anti-neutrophil cytoplasmic antibodies are a gaggle of autoantibodies, mainly one of the IgG type, against antigens within the cytoplasm of neutrophil granulocytes  and monocytes. These antigens x=can be  detected as a biopsy during a number of autoimmune disorders, but are particularly related to systemic vasculitis, so called ANCA-associated vasculitides (AAV).

Methodes of detection of ANCAs

ANCA IF Patterns

ELISA test

ANCA Antigen

Immunofluorescence (IF) on ethanol-fixed neutrophils is employed to detect ANCA, although formalin-fixed neutrophils could also be wont to help differentiate patterns. ANCA are often divided into four patterns when visualised by IF; cytoplasmic ANCA (c-ANCA), C-ANCA (atypical), perinuclear ANCA (p-ANCA) and atypical ANCA , also referred to as x-ANCA. c-ANCA shows cytoplasmic granular fluorescence with central interlobular accentuation. C-ANCA (atypical) shows cytoplasmic staining that's usually uniform and has no interlobular accentuation

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