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Articles On Chronic Urticaria | Open Access Journals
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Human Genetics & Embryology

ISSN: 2161-0436

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Articles On Chronic Urticaria

Chronic urticaria (UC) is a disturbing allergic skin condition. Although often mild, it can sometimes be a sign of a red flag for a serious internal disease. A multitude of etiologies have been implicated in the causation of UC, notably physical, infectious, vasculitic, psychological and idiopathic. An autoimmune basis for most "idiopathic" forms is now hypothetical. The histamine released by mast cells is the main effector of pathogenesis and is clinically characterized by papules which tend to reproduce. Laboratory investigations for a specific etiology are not always conclusive, although they may suggest an underlying condition. Clinical research of the associated systemic disease is strongly recommended in the appropriate circumstances. The mainstay of treatment remains H1 antihistamines. These can be combined with a complementary pharmacopoeia in the form of H2 inhibitors, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be necessary for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for the future. Phased management results in favorable results. An update on CU based on our experience with patients in a tertiary care center is presented.

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