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Cyclooxygenase | Open Access Journals
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Journal of Molecular Histology & Medical Physiology

ISSN: 2684-494X

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Cyclooxygenase

Cyclooxygenase regulate a key step in prostaglandin and thromboxane synthesis and are the targets of nonsteroidal antiinflammatory drugs (NSAIDs) . Prostaglandins are implicated in various pathophysiological processes such as inflammatory reactions, gastrointestinal cytoprotection, hemostasis and thrombosis, as well as renal hemodynamics. Cyclooxygenase enzymes catalyze the double dioxygenation of arachidonic acid to prostaglandin endoperoxides, the immediate precursors to prostaglandins and thromboxane. These lipid mediators act through multiple G-protein-coupled receptors to trigger a broad range of physiological and pathophysiological responses. Other ocular tissues such as cornea, lens and retina indicated less cyclooxygenase activity relative to uvea and conjunctiva.

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Citations: 33

Journal of Molecular Histology & Medical Physiology received 33 citations as per Google Scholar report

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