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Hydroxylation | Open Access Journals
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Hydrology: Current Research

ISSN: 2157-7587

Open Access

Hydroxylation

Hydroxylation reactions are typically very common reactions for compounds that have aromatic rings in their chemical structures. Because many drugs and xenobiotics consist of aromatic rings, hydroxyl derivatives are quite commonly seen in nature for both drugs and xenobiotics. Another very common hydroxylation reaction is seen in aliphatics. Of interest to cancer research are epoxidation reactions where unstable intermediates are formed. Although sometimes derived from polycyclic compounds, epoxide formation is important, as it is often the first step in aromatic hydroxylation, which may lead to carcinogen activation. The essential formula that underlies all hydroxylation reactions is seen as chemically modified with the addition of one or more hydroxyl groups (–OH). In the example given in  alkene (starting compound) is oxidized through the addition of hydroxyl groups.

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