The LEP gene codes for a protein secreted by white adipocytes, which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake or regulate energy expenditure to maintain the consistency of body fat. This protein has several endocrine functions and is involved in the regulation of immune and inflammatory responses, angiogenesis, hematopoiesis and wound healing. Mutations in this gene cause severe obesity and morbid obesity with hypogonadism. This gene is also linked to the development of type 2 diabetes mellitus. The LEP gene is located from base pair 128 241 188 to base pair 128 257 628 on chromosome 7. The structure of leptin consists of four helices complex, similar to those of cytokines. Leptin is produced by white adipose tissue, the most common form of adipose tissue in mammals.
Editorial: Journal of Diabetic Complications & Medicine
Editorial: Journal of Diabetic Complications & Medicine
Review Article: Journal of Diabetic Complications & Medicine
Review Article: Journal of Diabetic Complications & Medicine
Scientific Tracks Abstracts: Pulmonary & Respiratory Medicine
Scientific Tracks Abstracts: Pulmonary & Respiratory Medicine
Scientific Tracks Abstracts: Alternative & Integrative Medicine
Scientific Tracks Abstracts: Alternative & Integrative Medicine
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Keynote: Cancer Science & Therapy
Keynote: Cancer Science & Therapy
AcceptedAbstracts: Cancer Science & Therapy
AcceptedAbstracts: Cancer Science & Therapy
Journal of Diabetic Complications & Medicine received 102 citations as per Google Scholar report
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