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Sarcoma | Open Access Journals
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Journal of Tissue Science and Engineering

ISSN: 2157-7552

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Sarcoma

Sarcomas are classified according to the type of tissue, derived from mesoderm or neuroectoderm, that they most resemble, including fat, fibrous tissue, smooth and skeletal muscle, endothelium, bone, cartilage, and nerve. The World Health Organization consensus classification of tumors of soft tissue and bone also includes a group of tumors of uncertain differentiation. Moreover, new entities and new genetic findings in established sarcoma subtypes continue to be described. Due to their rarity, comparatively little is known about their biology. Many sarcomas are associated with characteristic genetic aberrations, which are useful for diagnosis. Gene expression profiling studies of large numbers of tumors can separate diagnostic and prognostic tumor subclasses, and may help to identify key genes and pathways for targeted therapy. Distinct expression patterns are present in many sarcomas, including pleomorphic sarcoma, rhabdomyosarcoma, Ewing sarcoma, and liposarcoma. Increasing insights into sarcoma biology, including from the use of next-generation sequencing methods, will contribute to better classification and understanding of behavior and prognosis, and importantly the oncogenetic mechanisms that will help to develop specific, targeted forms of treatment.    The acquisition of these specific translocations may be sufficient to initiate tumor formation in some cases. Local growth of sarcomas may result in death by compromise of vital structures. Most sarcomas metastasize hematogenously, and lymph node metastases from sarcomas are unusual.

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Citations: 807

Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report

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