Short Communication - (2021) Volume 5, Issue 5
Received: 03-Sep-2021
Published:
24-Sep-2021
, DOI: 10.37421/2736-657X.2021.5.137
Citation: Nonyelum Stella, Nwankwo and Neda Shaghaghi. “A Note on Drug Discovery Approach for Malaria.” Virol Curr Res (2021) 5: 137.
Copyright: © 2021 Stella NN et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution and reproduction in any medium, provided the original author and source are credited.
It is important to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to ease the symptoms, the liver stage to stop deteriorations, and the transmission stage to defend other humans. The tube for the blood stage is flattering healthy, but this should not be a source of satisfaction, as the current treatments set a high standard. Drug discovery labors directed close the liver and transmission phases are in their beginning but are getting increasing care as directing these stages could be contributory in eliminating malaria.
Malaria • Drug • Antimalarial
Malaria remains one of the most prevalent and deadly infectious diseases across worldwide. According to WHO 154-289 million malaria cases in the year of 2010, with 660,000 subordinate deaths. Numerous species of Plasmodium cause malaria in humans: Plasmodium vivax, Plasmodium ovale, Plasmodium falciparum, Plasmodium malariae and the simian Plasmodium knowlesi [1]. The most lethal species is P. falciparum, originate mainly in Africa. Plasmodium falciparum reasons organ disappointments (severe malaria) and accrues in the brain capillaries (cerebral malaria), foremost to coma and eventually death. Furthermore, there is growing evidence that the lethality of Plasmodium vivax has remained undervalued. The parasite has a multifaceted life cycle and in instruction to eliminate the disease, every stage should be careful for treatment those are Liver stage, Mosquito stage, Blood stage, Transmission stage [2].
Drugs that board the liver and transmission phases have the possible to be transformational, but research labors have been disadvantaged by the absence of high-throughput shades. New imaging techniques are commencement to solve this problem and open up novel avenues, with an advanced clinical compound consuming liver stage movement. The arena of transmission-blocking mediators is in its beginning, but may be most transformative of all in attaining the final goal of eliminating malaria.
Virology: Current Research received 187 citations as per Google Scholar report
