Anaerobic Cattle Compost Consumption of the Antibiotics and its Mechanisms

Muhammad Zubair^*
*Correspondence: Muhammad Zubair, Department of Animal Science and Veterinary Medicine, Tsinghua University, Beijing, China, Email:

Introduction

Antibiotics play a crucial role in livestock production by maintaining animal health and preventing diseases. However, their excessive use can lead to the development of antibiotic resistance, posing significant risks to human and animal health. In recent years, alternative methods to mitigate antibiotic residues and their effects on the environment have gained attention. Anaerobic cattle compost consumption has emerged as a promising strategy to address this issue. This process involves feeding cattle with compost containing antibiotic residues, which are subsequently broken down through anaerobic digestion. This article aims to explore the mechanisms behind anaerobic cattle compost consumption and its potential for reducing antibiotic residues in the environment. Anaerobic cattle compost consumption involves feeding cattle with compost that contains antibiotic residues. Compost is a mixture of organic waste materials, such as animal manure, crop residues, and bedding materials, which undergoes decomposition through anaerobic digestion. The composting process creates an environment conducive to the growth of anaerobic microorganisms that break down organic matter [1].

When cattle consume compost containing antibiotic residues, the compost undergoes digestion in their rumen, a specialized fermentation chamber. The rumen houses a complex microbial ecosystem that includes bacteria, archaea, protozoa, and fungi. These microorganisms play a crucial role in the digestion of feed and organic matter, including the breakdown of antibiotic residues.

Microbial degradation: The primary mechanism behind the breakdown of antibiotics in anaerobic cattle compost consumption is microbial degradation. The diverse microbial community present in the rumen possesses a wide range of enzymes capable of metabolizing various compounds, including antibiotics. Some bacteria and archaea have specific enzymes that can degrade antibiotics, such as β-lactamases that hydrolyze β-lactam antibiotics like penicillin. Anaerobic digestion creates an oxygen-free environment, which is favorable for the growth and activity of anaerobic microorganisms. Many antibiotics are susceptible to degradation in the absence of oxygen, as aerobic degradation pathways are inhibited. Under anaerobic conditions, certain microorganisms can utilize antibiotics as a carbon and energy source, leading to their breakdown [2].

Different classes of antibiotics may undergo distinct biodegradation pathways. For example, tetracycline antibiotics can be transformed through processes like reductive dechlorination and anaerobic demethylation. Sulfonamides can be degraded through anaerobic reduction reactions, while macrolide antibiotics may be metabolized through hydrolysis or reduction reactions. Synergistic microbial interactions: Microbial degradation of antibiotics in the rumen often involves synergistic interactions among different microorganisms. Some microorganisms may produce enzymes that degrade certain antibiotic classes, while others may provide essential cofactors or metabolic byproducts. This cooperative action allows for the efficient breakdown of antibiotics in the complex ruminal ecosystem [3].

Description

In addition to microbial degradation, metabolic resistance mechanisms in rumen microorganisms can contribute to the breakdown of antibiotics. Some microorganisms have developed metabolic pathways that bypass the inhibitory effects of antibiotics, allowing them to survive and metabolize these compounds. Anaerobic cattle compost consumption offers several potential benefits in addressing the issue of antibiotic residues in the environment. Firstly, it provides an environmentally friendly approach to reduce the levels of antibiotics in compost and subsequently in manure, minimizing their release into the environment. Secondly, by facilitating the breakdown of antibiotics, this process can potentially reduce the selective pressure for antibiotic resistance in the rumen microbial community [4].

However, their excessive and indiscriminate use has led to the emergence of antibiotic-resistant bacteria, posing a significant threat to human and animal health. Anaerobic composting of cattle manure has gained attention as a potential method to mitigate antibiotic contamination. This article explores the consumption of antibiotics by anaerobic cattle compost and the underlying mechanisms involved. Cattle raised for meat and dairy production are often administered antibiotics to prevent and treat infections. As a result, the antibiotics and their metabolites are excreted in the manure. This leads to the accumulation of antibiotics in livestock waste, which can contaminate soil, water, and crops when used as fertilizer.

Anaerobic composting involves the decomposition of organic matter in the absence of oxygen. This process occurs naturally in anaerobic digesters, where microorganisms break down organic materials, including cattle manure, into compost. Anaerobic conditions have been found to facilitate the degradation of antibiotics.

Microbial degradation: Anaerobic composting provides an environment conducive to the growth of diverse microbial communities, including bacteria, archaea, and fungi. Some of these microorganisms possess the ability to degrade antibiotics through enzymatic reactions. For example, certain bacteria produce enzymes such as β-lactamases, which can hydrolyze and inactivate β-lactam antibiotics.

Sorption and Adsorption: Antibiotics present in cattle manure can be sorbed or adsorbed onto organic matter, such as lignin and cellulose, during the composting process [5].

Conclusion

Chemical Transformations: Anaerobic conditions promote various chemical transformations that can alter the structure and properties of antibiotics. For instance, sulfonamides can undergo reduction reactions, resulting in the formation of less biologically active compounds. During anaerobic composting, microorganisms compete for available nutrients. This competition can limit the growth of antibiotic-resistant bacteria, as they may have a competitive disadvantage compared to non-resistant strains. The reduced microbial abundance of resistant bacteria contributes to the overall decrease in antibiotic resistance genes. The optimal temperature range for anaerobic composting varies depending on the specific microorganisms involved. Higher temperatures can enhance the degradation of antibiotics and promote the growth of microbial communities that are more efficient at antibiotic degradation.

Acknowledgement

None.

Conflict of Interest

There is no conflict of interest by author.

References

1. Van Boeckel, Thomas P., Charles Brower, Marius Gilbert and Bryan T. Grenfell, et al. "Global trends in antimicrobial use in food animals."Proc Natl Acad Sci112 (2015): 5649-5654.

Google Scholar, Crossref, Indexed at

2. Van, Thi Thu Hao, Zuwera Yidana, Peter M. Smooker and Peter J. Coloe. "Antibiotic use in food animals worldwide, with a focus on Africa: Pluses and minuses."J Glob Antimicrob Resist 20 (2020): 170-177.

Google Scholar, Crossref, Indexed at

3. Hao, Haihong, Guyue Cheng, Zahid Iqbal and Xiaohui Ai, et al. "Benefits and risks of antimicrobial use in food-producing animals."Front Microbial 5 (2014): 288.

Google Scholar, Crossref, Indexed at

4. Motoyama, Miki, Shuhei Nakagawa, Rumi Tanoue and Yuri Sato, et al. "Residues of pharmaceutical products in recycled organic manure produced from sewage sludge and solid waste from livestock and relationship to their fermentation level."Chemosphere84 (2011): 432-438.

Google Scholar, Crossref, Indexed at

5. Mackie, Roderick I., Satoshi Koike, Ivan Krapac and Joanne Chee-Sanford, et al. "Tetracycline residues and tetracycline resistance genes in groundwater impacted by swine production facilities."Anim Biotechnol 17 (2006): 157-176.

Google Scholar, Crossref, Indexed at