Annals of Hepatology Strives to Disseminate the Best Regional and Worldwide Advancements

Thomas Marck^*
*Correspondence: Thomas Marck, Department of Molecular Biology in Medicine, Leiden University, Netherlands, Email:

Editorial

By comparing the latest versions of the guidelines published a paper earlier this year detailing the common grounds and regional variances for the therapy of hepatocellular carcinoma. The American, European, and Canadian Clinical Practise Guidelines (CPG) as well as Asia Pacific. Such disparities could be attributed not only to the availability of medical therapies, but also to the genetic and environmental factors that play a role in the development of liver disease in every given community. These findings highlight the importance for hepatology associations around the world to document actual variations from international consensus in their regional guidelines. The importance of regional CPGs, as well as how they are generated and evaluated, has previously been highlighted. In line with this trend, the Latin American Association for the Study of the Liver (ALEH) [Asociación Lati noamericana para el Estudio del Hgado] recently published the CPG of the Latin American Association for the Study of the Liver (ALEH) [Asociación Latinoamericana para el Estudio del Hgado] for the management of alcohol-related liver disease, which takes into account the differences in alcoholic beverages and genetic variability. However, in Mexico and other Latin American countries, more regional guidelines are required, whether for the use of Hepatitis B and C antivirals or non-prescription medicines. Unfortunately, there is a dearth of reliable national research studies due to a lack of reliable national research studies. is a trend toward adopting the worldwide CPG under the assumption that the recommendations will be followed in the countries of origin. It is, nonetheless, It is well recognised that people have different genetic and cultural backgrounds.

The continents of the Americas the lack of regional CPG is a significant barrier for doctors in their daily medical practise, according to the national medical association. Societies and health-care systems are also affected. When it comes to updating CPG, the increased amount of biomedical knowledge gained in the last 30 years as a result of developments in science, technology, and interdisciplinary contacts has a substantial impact. The discovery of the structure of the DNA molecule, which paved the way for the development of recombinant DNA techniques and in vitro amplification of DNA using various PCR techniques, was a watershed moment in medicine. Researchers were able to analyse superior eukaryotic genomes and combine what they had learned before in biochemistry, cell biology, and immunology. With these new developments, the discipline of medicine undergoes a paradigm change known as genomic medicine, which includes innovative molecular biology tests into the usual diagnostic algorithm as well as other advances. Academic departments specialising in molecular biology in medicine, as well as the creation of academic books and scientific periodicals connected to molecular biology in medicine, appeared during this time.

Parallel to these developments, more rapid and effective nucleic acid sequencing techniques were developed, culminating in the production of the first blueprint of the human genome in 2003, a watershed moment between the pre- and post-genomic era. Although the entire sequencing of the human genome was a significant accomplishment, there was still more to come as sequencing techniques advanced to a new era of high-throughput technologies such as New Generation Sequencing (NGS). When compared to earlier stages, the cost and time to build solid human genome or exome datasets is greatly lowered by NGS. In addition, large-scale studies of transcriptomes, proteomes, and metabolomes have resulted in "Big Data" for the omics sciences, which include genomics, transcriptomics, proteomics, and metabolomics, respectively. If it weren't for the rise of other sciences to arrange, classify, and correlate these databases, the tremendous volume of "Big Data" would be pandemonium. Bioinformatics and data mining, in collaboration with computational engineering, are trying to integrate and develop new automated electronic systems to aid clinical decision-making in a number of medical specialties. Given these remarkable developments, we can now distinguish between the before and after in the realm of medicine, with positive implications for patients. Furthermore, these novel database methods are revealing disparities in people's gene-environment interactions, which influence illness progression and severity. It also emphasises the significance of assessing elements unique to each group, such as eating habits, culture, religion, and emotions. They will also improve precision in the management of infectious-contagious diseases, where viral genetic variability and regional risk factor epidemiology distinguish between disease progression and severity, as well as response to specific treatments.

We really wanted to make sure that we represented the diversity of work on planning and forecasting for large-scale emergencies when soliciting and choosing articles for this issue. Disasters threaten all societies, anywhere in the world, but disaster management is organised differently in different countries and even different areas of the same country. As a result, we wanted to make sure that our work covered a wide range of countries, which we do, including Australia, Cyprus, Finland, Israel, Italy, Malaysia, Romania, Spain, and the United Kingdom, as well as the United States. Second, rather than merely academics, we wanted to include the opinions of actual managers and practitioners; two of the articles chosen are case studies by practitioners. Finally, we wanted ssto include a wide range of research approaches, so we have papers based on case studies, unstructured interviews, coding and statistical analysis of literature review results, surveys, and modelling. We can understand why failures and errors occurred, as well as what we can do to enhance all phases of emergency response [1-5].

Acknowledgement

We thank the anonymous reviewers for their constructive criticisms of the manuscript. The support from ROMA (Research Optimization and recovery in the Manufacturing industry), of the Research Council of Norway is highly appreciated by the authors.

Conflict of Interest

The Author declares there is no conflict of interest associated with this manuscript.

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