Abstract

Natural product biodiversity provides a large supply of drug discovery leads. Natural products are thought to be more likely to produce therapeutic hits because they have a higher number of stereo centres, which increases scaffold diversity provided by organic structures with more fused, bridging, and Spiro carbocyclic rings. The effective separation of resveratrol from grapes has highlighted the benefits of red wine consumption in supporting metabolic health, implying medicinal promise as a therapy for metabolic disorders. Natural products or their semisynthetic derivatives account for over 40% of all pharmaceuticals, 60% of anticancer drugs, and 80% of antimicrobials in clinical use. The emerging trends in pharmaceutical development are synthetic forms of natural products.