GET THE APP

Clinicocytological Analysis of Hepatic Neoplastic Lesions
..

Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

Extended Abstract - (2021) Volume 12, Issue 6

Clinicocytological Analysis of Hepatic Neoplastic Lesions

Dr. Garg Rachana M.D1* and Dr. Anuradha C.K. Rao M.D2
*Correspondence: Dr. Garg Rachana M.D, Jawaharlal Nehru Cancer Hospital and Research Centre, Formerly Post Graduate student at Kasturba Medical College, Manipal, India,
1Jawaharlal Nehru Cancer Hospital and Research Centre, Formerly Post Graduate student at Kasturba Medical College, Manipal, India
2Department of Pathology, Yenepoya Medical College, Mangalore, Formerly Professor at Kasturba Medical College, Manipal, India

Received: 14-Jun-2021 Published: 30-Jun-2021 , DOI: 10.37421/2157-7099.2021.12.580
Citation: Dr. Garg Rachana M.D and Dr. Anuradha C.K. Rao M.D. "Clinicopathological Analysis of Hepatic Neoplastic Lesions with Particular Reference to Morphological Pattern Assessment." J Cytol Histol 12 (2021): 580.
Copyright: © 2021 Garg Rachana. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The liver is the site of numerous neoplastic and non-neoplastic lesions, with neoplastic lesions accounting for a prominent cause of morbidity and mortality. Being a common site for metastatic tumors, it becomes imperative to differentiate the same from hepatocellular carcinoma, owing to varied management modalities involved. Diagnosis by fine needle aspiration cytology (FNAC),is considered a prominent investigative procedure in this regard. However, it is not without its limitations and disadvantages.

Aim and Objectives: This retrospective research analyzes the cytological features of hepatic masses, with particular reference to pattern assessment, cellular and nuclear details along with background characteristics of note which could define differentiating characteristics of hepatocellular carcinoma from metastatic malignancy. Accompanying clinico-radiological and biochemical parameters that could be helpful in this regard were also studied. An attempt was also made to distinguish the features characteristic to different grades of hepatocellular carcinoma (HCC).

Method: FNAC of 114 hepatic neoplastic lesions received during a two years period in the pathology department of a tertiary care hospital were retrospectively analyzed. Clinico-radiological and biochemical parameters were correlated, and data thus retrieved was analyzed statistically for relevance. Results: Males were predominantly affected both by primary and metastatic malignancy with primary over 60 years of age. Jaundice, history of prior alcohol consumption, pre-existing liver disease, elevated LFT along with AFP levels >400 ng/ml was seen in significant cases of hepatocellular carcinoma. Radiologically, metastasis showed multiple lesions with most cases less than 5cms in diameter with invasion of adjacent structures. Analysis of three characteristic cytological features including presence of cytoplasmic bile, intranuclear inclusions and traversing blood vessel was carried out and it was observed that the highest chance of tumor being HCC was when all three were seen. After analyzing features to differentiate between the different grades of HCC it was observed that as the grades progressed the cells became undifferentiated and similarities increased. Cytohistological correlation was seen in 91.3% of cases of primary and 86.9% of metastatic malignancies.

Conclusion: Close attention to cytological features like cell clusters, intranuclear inclusions, endothelial rimming in conjunction with radiological images and biochemical markers provide valuable pointers in distinguishing between primary HCC and hepatic metastatic carcinomas thus obviating the need of invasive procedures.

Keywords

Hepatocellular carcinoma • Cytology • Intranuclear inclusions

Google Scholar citation report
Citations: 2334

Journal of Cytology & Histology received 2334 citations as per Google Scholar report

Journal of Cytology & Histology peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward