Crohn's Disease: A Topic of Discussion

Nour Taher^*
*Correspondence: Nour Taher, Department of Gastroenterology and Hepatology, Mayo Clinic, USA, Email:

Brief Report

Inflammatory bowel disease (IBD) refers to a set of inflammatory disorders of the colon and small intestine, the most common of which are Crohn's disease and ulcerative colitis. Crohn's disease typically affects the small and large intestines, as well as the mouth, oesophagus, stomach, and anus, whereas ulcerative colitis primarily affects the colon and rectum. Crohn's disease is an inflammatory bowel disease (IBD) that can affect any part of the digestive tract. Stomach pain, diarrhoea (which may be bloody if the inflammation is severe), fever, abdominal distension, and weight loss are common symptoms. Infections, as well as pyoderma gangrenosum or erythema nodosum, can cause skin rashes. Bowel blockage can arise as a result of chronic inflammation, and those who have the disease are more likely to develop colon cancer and small bowel cancer. While the exact causes of Crohn's disease are unknown, it is thought to be caused by a mix of environmental, immunological, and bacterial factors in genetically vulnerable people.

More than 70 genes have been discovered to be linked in more than half of the overall risk. Tobacco smokers are twice as likely as nonsmokers to acquire Crohn's disease. It also frequently follows gastroenteritis. A multitude of observations, including a biopsy and the look of the gut wall, medical imaging, and a description of the condition, are used to make a diagnosis. Crohn's disease affects approximately 3.2 per 1,000 persons in Europe and North America, and approximately 1.54 per 1000 in the United Kingdom. In Asia and Africa, it is less common. Many Crohn's disease patients suffer symptoms for years before being diagnosed. The most common age of onset is in the teens and twenties, but it can occur at any age.

Crohn's illness may also cause perianal pain. Itchiness or soreness around the anus may indicate inflammation of the anus or perianal problems such as anal fissures, fistulae, or abscesses. Perianal skin tags are also frequent in Crohn's disease and can occur with or without colorectal polyps. Fecal incontinence can occur alongside perianal Crohn's disease. Despite the fact that Crohn's and UC are completely distinct diseases, both can cause abdominal pain, diarrhoea, rectal bleeding, severe internal cramps/muscle spasms in the pelvic region, and weight loss. The most common extraintestinal consequence of inflammatory bowel disease is anaemia. Crohn's disease, like many other chronic, inflammatory disorders, can cause a variety of systemic symptoms. Growth failure is prevalent in children. Many children are diagnosed with Crohn's disease as a result of their failure to sustain growth. Up to 30% of children with Crohn's disease may have growth retardation, which may appear during the puberty growth spurt. Pleuropericarditis in children and adults with IBD has been recorded infrequently (1%), either at the time of initial presentation or during active or quiescent disease. The cause of pleuropericarditis is unknown, while certain drugs (such as sulfasalazine and mesalamine derivatives) have been linked to the condition in some patients. Chest discomfort, dyspnea, or, in extreme cases, pericardial tamponade necessitating immediate drainage may be present. Crohn's disease is a complex autoinflammatory illness [1-5].

Crohn's disease's etiopathogenesis is yet unknown. In any case, a loss of the immune apparatus's regulating function would be implicated in the disease's onset. In this regard, as with Blau's disease (a monogenic autoinflammatory illness), NOD2 gene mutations have been related to Crohn's disease. Crohn's disease is a complex autoinflammatory illness. Crohn's disease's etiopathogenesis is yet unknown. In any case, a loss of the immune apparatus's regulating function would be implicated in the disease's onset. In this regard, as with Blau's disease (a monogenic autoinflammatory illness), NOD2 gene mutations have been related to Crohn's disease.

References

1. Cottone, Mario, Sara Renna, Ambrogio Orlando and Filippo Mocciaro, et al. "Medical management of Crohn's disease." Expert Opin Pharmacother 12 (2011): 2505-2525.

Google Scholar, Crossref

2. Norton, Beth-Ann, Rosemarie Thomas, Kathleen G. Lomax and Sharon Dudley-Brown, et al. "Patient perspectives on the impact of Crohn’s disease: results from group interviews." Patient Preference Adherence 6 (2012): 509.

Google Scholar, Crossref

3. Williamson, Paul R., Michael D. Hellinger, Sergio W. Larach and Andrea Ferrara, et al. "Twenty-year review of the surgical management of perianal Crohn's disease." Dis Colon Rectum 38 (1995): 389-392.

Google Scholar, Crossref

4. Schlussel, Andrew T., Scott R. Steele and Karim Alavi. "Current challenges in the surgical management of Crohn's disease: a systematic review." Am J Surg 212 (2016): 345-351.

Google Scholar, Crossref

5. Bousvaros, A., D.A. Antonioli, R.B. Colletti and M. C. Dubinsky, et al. "Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America." J Pediatr Gastroenterol Nutr 44 (2007): 653-674.

Google Scholar, Crossref