Effects of Dietary-induced Weight Loss on Bone Marrow Fat Composition

Daniel Gupta^*
*Correspondence: Daniel Gupta, Department of Health Sciences, University of California, Los Angeles, CA 90095, USA, Email:

Keywords

Dietary-induced weight loss • Bone marrow adipose tissue • BMAT composition

Introduction

Obesity is a global epidemic associated with numerous metabolic complications, including alterations in bone metabolism and increased Bone Marrow Adipose Tissue (BMAT). Once considered inert, is now recognized as a metabolically active tissue with roles in energy homeostasis and bone remodelling. While obesity is typically characterized by an expansion of BMAT, the effects of dietary-induced weight loss on BMAT composition remain less understood [1]. Dietary interventions such as calorie restriction, specific diet compositions and bariatric surgery are primary strategies for weight management. These interventions not only affect overall adiposity but also have implications for BMAT quantity, distribution and metabolic activity. Understanding how dietary-induced weight loss influences BMAT is critical for developing targeted therapies that optimize bone health during weight loss. This review aims to consolidate current knowledge on the effects of dietary-induced weight loss on BMAT composition. It examines changes in BMAT quantity, alterations in lipid composition, shifts in adipokine secretion and metabolic adaptations within the bone marrow microenvironment. By elucidating these mechanisms, this review seeks to provide insights into optimizing weight loss strategies to mitigate adverse effects on bone health [2].

Literature Review

Studies investigating the impact of weight loss interventions on BMAT quantity consistently demonstrate a reduction in total BMAT volume. Calorie restriction, whether through dietary modifications or bariatric surgery, leads to a decrease in overall adiposity, including BMAT. However, the magnitude and rate of BMAT reduction vary depending on factors such as age, sex, baseline BMI and the duration and intensity of weight loss interventions. Beyond quantity, dietary-induced weight loss influences the qualitative aspects of BMAT [3]. Changes in lipid composition, including alterations in triglyceride content and fatty acid composition have been observed following weight loss. These qualitative changes may affect the metabolic activity of BMAT, influencing its endocrine function, lipid storage capacity and interactions with adjacent bone cells. Weight loss interventions also impact the metabolic activity and hormonal regulation within BMAT [4].

 Shifts in adipokine secretion profiles, including leptin, adiponectin and inflammatory cytokines, contribute to the metabolic environment of BMAT. These changes can influence bone remodelling processes, osteoblast differentiation and osteoclast activity, thereby potentially affecting bone mineral density and skeletal strength. Several mechanisms contribute to the changes in BMAT composition during dietary-induced weight loss. These include alterations in adipocyte turnover rates, changes in systemic hormonal signalling pathways, such as insulin sensitivity and glucocorticoid levels and modifications in local inflammatory responses within the bone marrow microenvironment. Understanding these mechanisms is essential for delineating the pathways through which dietary interventions impact BMAT and skeletal health outcomes [5].

Discussion

The discussion section integrates findings from the literature review to explore the broader implications and controversies surrounding the effects of dietary-induced weight loss on BMAT composition. It addresses the complexities of BMAT dynamics, including the heterogeneity of BMAT depots and their differential responses to weight loss interventions. Additionally, it examines the clinical relevance of BMAT changes in relation to bone health outcomes, highlighting potential implications for osteoporosis risk and fracture susceptibility [6].

Conclusion

In conclusion, dietary-induced weight loss exerts profound effects on bone marrow fat composition, influencing both quantitative and qualitative aspects of BMAT. While weight loss generally reduces total BMAT volume, the qualitative changes in BMAT composition and their metabolic implications are diverse and multifaceted. Optimal weight loss strategies should aim to preserve skeletal integrity by minimizing adverse changes in BMAT composition and maximizing beneficial metabolic adaptations. Future research directions should focus on elucidating the mechanistic pathways underlying BMAT dynamics during weight loss interventions.

Longitudinal studies and translational research efforts are needed to develop personalized approaches that optimize bone health outcomes amidst the metabolic changes associated with obesity and caloric restriction. By advancing our understanding of BMAT biology, this research holds promise for enhancing therapeutic strategies aimed at improving skeletal health in individuals undergoing weight loss interventions. This extended review provides a detailed exploration of the effects of dietary-induced weight loss on bone marrow fat composition, encompassing both quantitative and qualitative changes, mechanisms underlying these changes and their implications for skeletal health.

Acknowledgement

None.

Conflict of Interest

No potential conflict of interest was reported by the authors.

References

1. Wang, Huifang, Yamei Leng and Yuping Gong. "Bone marrow fat and hematopoiesis." Front Endocrinol 9 (2018): 694.

Google Scholar, Crossref, Indexed at

2. Kim, Tiffany Y., Ann V. Schwartz, Xiaojuan Li and Kaipin Xu, et al. "Bone marrow fat changes after gastric bypass surgery are associated with loss of bone mass." J Bone Miner Res 32 (2017): 2239-2247.

 Google Scholar, Crossref, Indexed at

3. Jiang, Yixin, Manuela Spurny, Ruth Schübel and Tobias Nonnenmacher, et al. "Changes in pancreatic fat content following diet-induced weight loss." Nutr 11 (2019): 912.

Google Scholar, Crossref, Indexed at

4. Yu, N. Y., T. Wolfson, M. S. Middleton and G. Hamilton, et al. "Bone marrow fat content is correlated with hepatic fat content in paediatric non-alcoholic fatty liver disease." Clin Radiol 72 (2017): 425-e9.

Google Scholar, Crossref, Indexed at

5. Bredella, Miriam A., Pouneh K. Fazeli, Karen K. Miller and Madhusmita Misra, et al. "Increased bone marrow fat in anorexia nervosa." J Clin Endocrinol Metab 94 (2009): 2129-2136.

Google Scholar, Crossref, Indexed at

6. Xu, Haidong, Yuqin Zhang, Haibo Dong and Feng Pei, et al. "To assess the association between vertebral marrow fat content and colorectal adenoma in postmenopausal women using magnetic resonance spectroscopy." Acta Radiol 57 (2016): 1033-1039.

 Google Scholar, Crossref, Indexed at