Exploring Olmesartan Medoxomil Interaction with β-Cyclodextrin Derivatives

Chunuli Pendulinuma^*
*Correspondence: Chunuli Pendulinuma, Department of Pharmacy, University of Toledo, Toledo, OH 43606, USA, Email:

Introduction

Olmesartan medoxomil is a widely used Angiotensin II Receptor Blocker (ARB) indicated for the treatment of hypertension. Despite its efficacy, olmesartan medoxomil exhibits poor aqueous solubility, which may limit its bioavailability and therapeutic effectiveness. β-Cyclodextrin derivatives have been investigated as potential excipients to improve the solubility and dissolution rate of poorly soluble drugs such as olmesartan medoxomil [1]. This paper explores the interaction between olmesartan medoxomil and β-cyclodextrin derivatives, with a focus on their physicochemical properties, formulation strategies and potential implications for pharmaceutical development and clinical practice. Optimizing the formulation of olmesartan medoxomil is of paramount importance in ensuring its therapeutic efficacy and patient compliance, especially considering its widespread use in the management of hypertension. While olmesartan medoxomil is effective in lowering blood pressure and reducing cardiovascular risk, its poor aqueous solubility can limit its bioavailability and therapeutic effect. Therefore, the exploration of novel formulation strategies, such as the incorporation of β-cyclodextrin derivatives, presents an exciting avenue for enhancing the pharmaceutical properties of olmesartan medoxomil. This paper delves into the intricacies of the interaction between olmesartan medoxomil and β-cyclodextrin derivatives, shedding light on the underlying physicochemical mechanisms and formulation approaches. By elucidating the molecular interactions between olmesartan medoxomil and β-cyclodextrin derivatives, we aim to provide a comprehensive understanding of how these excipients can improve the solubility, dissolution rate and bioavailability of olmesartan medoxomil [2].

Description

Olmesartan medoxomil is a prodrug that undergoes hydrolysis to its active form, olmesartan, following oral administration. However, its low aqueous solubility poses challenges for formulation and drug delivery, potentially leading to variable pharmacokinetics and suboptimal therapeutic outcomes. β-Cyclodextrin derivatives, cyclic oligosaccharides composed of glucose units, have been explored as solubilizing agents to enhance the aqueous solubility and dissolution rate of olmesartan medoxomil. The interaction between olmesartan medoxomil and β-cyclodextrin derivatives is governed by complex physicochemical processes, including host-guest interactions, inclusion complex formation and drug release kinetics. β-Cyclodextrin derivatives possess a hydrophobic cavity that can accommodate hydrophobic drug molecules such as olmesartan medoxomil, forming inclusion complexes that increase drug solubility and bioavailability. Additionally, the encapsulation of olmesartan medoxomil within β-cyclodextrin derivatives may protect the drug from degradation and enhance its stability in aqueous media [3].

Formulation strategies incorporating β-cyclodextrin derivatives to improve the solubility and dissolution rate of olmesartan medoxomil include solid dispersion, inclusion complexation and nanoparticle formulation. Solid dispersion techniques involve dispersing olmesartan medoxomil within a matrix of β-cyclodextrin derivatives, leading to enhanced drug dissolution and absorption. Inclusion complexation methods utilize the formation of inclusion complexes between olmesartan medoxomil and β-cyclodextrin derivatives to increase drug solubility and bioavailability. Nanoparticle formulations encapsulate olmesartan medoxomil within nanoparticles composed of β-cyclodextrin derivatives, providing sustained release and targeted delivery of the drug. Several studies have investigated the use of β-cyclodextrin derivatives to improve the solubility and dissolution rate of olmesartan medoxomil in various dosage forms, including tablets, capsules and oral solutions. These studies have demonstrated promising results, with enhanced drug solubility, dissolution rate and pharmacokinetic profiles observed for olmesartan medoxomil formulations containing β-cyclodextrin derivatives. Furthermore, the use of β-cyclodextrin derivatives may enable dose reduction and improve patient compliance by reducing the pill burden associated with high-dose formulations of olmesartan medoxomil [4,5].

Conclusion

In conclusion, the interaction between olmesartan medoxomil and β-cyclodextrin derivatives represents a promising approach to enhance the solubility and dissolution rate of this poorly soluble drug. β-Cyclodextrin derivatives offer unique advantages as solubilizing agents, including their ability to form inclusion complexes with hydrophobic drugs, improve drug stability and enable targeted drug delivery. Formulation strategies incorporating β-cyclodextrin derivatives have shown potential to improve the pharmacokinetic and pharmacodynamic properties of olmesartan medoxomil, leading to enhanced therapeutic effectiveness and patient outcomes. Future research efforts should focus on optimizing the formulation parameters and dosage forms of olmesartan medoxomil-containing β-cyclodextrin complexes to maximize drug solubility, bioavailability and clinical efficacy. Additionally, further studies are needed to evaluate the safety, tolerability and long-term effects of olmesartan medoxomil formulations containing β-cyclodextrin derivatives in preclinical and clinical settings. By elucidating the interaction between olmesartan medoxomil and β-cyclodextrin derivatives and exploring their potential applications in pharmaceutical development, we can advance drug delivery technology and improve the therapeutic outcomes of patients receiving olmesartan medoxomil for the management of hypertension.

Acknowledgment

None.

Conflict of Interest

No conflict of interest.

References

1. Han, Dongxu, Zhongbao Han, Liyan Liu and Ying Wang, et al. "Solubility enhancement of myricetin by inclusion complexation with heptakis-O-(2-hydroxypropyl)-β-cyclodextrin: A joint experimental and theoretical study." Int J Mol Sci 21 (2020): 766.

Google Scholar, Crossref, Indexed at

2. Braga, Susana Santos. "Cyclodextrins: Emerging medicines of the new millennium." Biomolecules 9 (2019): 801.

Google Scholar, Crossref, Indexed at

3. Braga, Susana Santos, Firas El-Saleh, Karyna Lysenko and Filipe A. Almeida Paz. "Inclusion compound of efavirenz and γ-cyclodextrin: Solid state studies and effect on solubility." Molecules 26 (2021): 519.

Google Scholar, Crossref, Indexed at

4. Sahakijpijarn, Sawittree, Chaeho Moon, John J. Koleng and Dale J. Christensen, et al. "Development of remdesivir as a dry powder for inhalation by thin film freezing." Pharmaceutics 12 (2020): 1002.

Google Scholar, Crossref, Indexed at

5. Vakali, Vasiliki, Michail Papadourakis, Nikitas Georgiou and Nikoletta Zoupanou, et al. "Comparative interaction studies of quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2, 6-Methylated-β-cyclodextrin." Molecules 27 (2022): 5490.

Google Scholar, Crossref, Indexed at