From Plate to Cells: Unveiling Absolute Bioavailability\'s Influence on Food Digestion and Assimilation

Chunguda Shen^*
*Correspondence: Chunguda Shen, Department of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China, Email:

Introduction

The journey of nutrients from the plate to the cells involves a complex interplay of digestive processes and absorption mechanisms. Absolute bioavailability, a critical concept in nutrition science, plays a pivotal role in determining the efficiency with which nutrients are absorbed and utilized by the body. By understanding how absolute bioavailability influences food digestion and assimilation, we gain insights into optimizing dietary choices for improved health outcomes. This article explores the intricate relationship between absolute bioavailability and the journey of nutrients from plate to cells. Absolute bioavailability refers to the fraction of a nutrient that enters systemic circulation unchanged after ingestion, providing insights into its absorption and utilization by the body. It encompasses various factors, including the chemical form of the nutrient, interactions with other dietary components, gastrointestinal processing, and individual differences in digestion and metabolism. By quantifying the extent and efficiency of nutrient absorption, absolute bioavailability elucidates the effectiveness of dietary nutrients in fulfilling physiological requirements. Absolute bioavailability influences the digestive processes that occur following food ingestion, shaping the fate of nutrients within the gastrointestinal tract [1].

Description

Factors such as nutrient solubility, chemical form, and food matrix composition affect their accessibility for digestion and absorption. For instance, soluble nutrients may undergo rapid dissolution and absorption in the small intestine, while insoluble fibers may undergo fermentation by gut microbiota in the large intestine, influencing nutrient release and bioavailability. Absolute bioavailability dictates the extent to which nutrients are assimilated into the bloodstream and transported to cells for utilization. Nutrients with high bioavailability are efficiently absorbed across the intestinal epithelium and enter systemic circulation, where they can be distributed to various tissues and organs. Conversely, nutrients with low bioavailability may undergo limited absorption or encounter barriers to uptake, affecting their availability for cellular metabolism and physiological functions. The chemical form of a nutrient profoundly influences its bioavailability. Different forms of nutrients, such as organic vs. inorganic compounds or natural vs. synthetic sources, may exhibit variations in absorption rates and metabolic fates. For example, heme iron from animal sources is more readily absorbed than non-heme iron from plant-based foods due to differences in chemical structure and absorption mechanisms. The composition of foods and their interactions with other nutrients can impact absolute bioavailability [2].

Factors such as the presence of dietary fibers, proteins, fats, and phytochemicals may enhance or inhibit nutrient absorption by modulating gastrointestinal transit time, enzymatic activity, and nutrient transport mechanisms. Digestive processes within the gastrointestinal tract influence nutrient bioavailability by breaking down complex food structures and facilitating nutrient release. Factors such as gastric acidity, bile secretion, enzyme activity, and intestinal transit time play crucial roles in nutrient digestion and absorption, ultimately determining their bioavailability and metabolic fate. The nutritional value of foods extends beyond the sum of their individual nutrients, owing to the intricate interplay of components within the food matrix. The food matrix, composed of macronutrients, micronutrients, fibers, phytochemicals, and other bioactive compounds, exerts a profound influence on nutrient bioavailability. Understanding the complexities of food matrix composition is essential for optimizing nutrient absorption and promoting overall health. This article explores the significance of food matrix composition in shaping nutrient bioavailability and its implications for dietary choices. The solubility of nutrients within the food matrix influences their release and absorption in the gastrointestinal tract [3].

Soluble nutrients, such as vitamins and some minerals, may dissolve readily in water and exhibit higher bioavailability. In contrast, insoluble nutrients or those encapsulated within cellular structures may require enzymatic breakdown or specific digestive processes for liberation and absorption.Interactions between nutrients and other components within the food matrix can modulate their bioavailability. For example, certain dietary fibers may form complexes with minerals, reducing their absorption, while others may enhance nutrient solubility or transit time in the gastrointestinal tract. Phytochemicals may also influence nutrient absorption through synergistic or antagonistic interactions. The presence of enzymes within the food matrix and the digestive tract facilitates the breakdown of complex nutrients into absorbable forms. Enzymatic activity may vary depending on food processing methods, ripeness, and cooking techniques, affecting nutrient accessibility and bioavailability. For instance, cooking can denature proteins, making them more digestible, while sprouting grains may enhance enzyme activity and nutrient bioavailability. The physical structure and particle size of foods within the matrix can impact nutrient absorption kinetics. Fine grinding, blending, or processing may increase the surface area available for enzymatic action and facilitate nutrient absorption. Conversely, intact cellular structures or encapsulated nutrients may require longer digestion times or specialized transport mechanisms for absorption [4].

Incorporating a variety of fruits, vegetables, whole grains, and legumes into the diet to maximize nutrient diversity and bioavailability. The food matrix composition plays a pivotal role in shaping nutrient bioavailability and influencing dietary choices. By understanding how macronutrients, micronutrients, fibers, and phytochemicals interact within the food matrix, individuals can make informed decisions to optimize nutrient absorption and promote overall health. Embracing a diet rich in diverse, minimally processed foods ensures a balanced nutrient intake and maximizes the bioavailability of essential nutrients, supporting long-term well-being. Nutrient interactions refer to the dynamic relationships between different nutrients within the body, influencing their absorption, metabolism, and physiological effects. These interactions play a crucial role in determining overall nutritional status and health outcomes. Understanding the complexities of nutrient interactions is essential for optimizing dietary choices and promoting optimal health. Vitamin C enhancing the absorption of non-heme iron from plant-based foods. Magnesium and calcium competing for absorption in the intestine when consumed in high doses simultaneously. High intake of dietary fiber competing with bile acids for cholesterol absorption, leading to reduced cholesterol levels [5].

Conclusion

Absolute bioavailability serves as a guiding principle in understanding the journey of nutrients from the plate to the cells. By elucidating the factors influencing nutrient absorption and utilization, absolute bioavailability provides valuable insights into optimizing dietary choices for improved health outcomes. Embracing a holistic approach to nutrition that considers absolute bioavailability empowers individuals to make informed dietary decisions that support optimal nutrient digestion, assimilation, and utilization, ultimately promoting overall health and well-being.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Jacobs Jr, David R., Myron D. Gross and Linda C. Tapsell. "Food synergy: An operational concept for understanding nutrition." Am J Clin Nutr 89 (2009): 1543S-1548S.

Google Scholar, Crossref, Indexed at

2. Frum, Adina, Carmen Maximiliana Dobrea, Luca Liviu Rus and Lidia-Ioana Virchea, et al. "Valorization of grape pomace and berries as a new and sustainable dietary supplement: Development, characterization, and antioxidant activity testing." Nutrients 14 (2022): 3065.

Google Scholar, Crossref, Indexed at

3. Malek, Sri Nurestri Abdul, Chung Weng Phang, Halijah Ibrahim and Norhanom Abdul Wahab, et al. "Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes." Molecules 16 (2011): 583-589.

Google Scholar, Crossref, Indexed at

4. Khoo, Hock Eng, Azrina Azlan, Sou Teng Tang and See Meng Lim. "Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits." Food & nurt res (2017).

Google Scholar, Crossref

5. Mureşan, Mariana, Diana Olteanu, Gabriela Adriana Filip and Simona Clichici, et al. "Comparative study of the pharmacological properties and biological effects of polygonum aviculare L. Herba extract-entrapped liposomes vs. quercetin-entrapped liposomes on doxorubicin-induced toxicity on HUVECs." Pharmaceutics 13 (2021): 1418.

Google Scholar, Crossref, Indexed at