Illuminating Disease Detection: Exploring the Properties and Applications of Carbon Quantum Dots (CQDs) in Biosensors

Anne Zhao^*
*Correspondence: Anne Zhao, Department of Biomedical Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, P.R. China, Email:

Introduction

Utilizing Carbon Quantum Dots (CQDs) in biosensors for disease detection has garnered more attention in recent years. These nanomaterials, with their novel optical properties and biocompatibility, hold extraordinary commitment in propelling the field of diagnostics. The purpose of this comprehensive review is to investigate the characteristics of CQDs and their applications in biosensors for disease detection. We can gain a deeper comprehension of how CQDs can contribute to accurate and sensitive disease diagnostics by shedding light on advancements in this field. One of the key advantages of CQDs in disease detection lies in their exceptional optical properties [1]. These dots exhibit strong photoluminescence, meaning they emit bright and tunable fluorescence upon excitation. This fluorescence can be easily observed and quantified, making CQDs ideal candidates for biosensing applications. Moreover, the fluorescence emission of CQDs can be easily modulated by altering their size, surface functionalization, or surrounding environment, allowing for precise control and manipulation [2].

Description

Carbon Quantum Dots (CQDs) are nanoscale carbon-based materials with exceptional optical properties, including strong fluorescence, high photo stability, and tunable emission wavelengths. These properties make them ideal candidates for biosensing applications. In biosensors, CQDs can serve as both sensing elements and signal transducers, enabling the detection and quantification of disease-related biomarkers with high sensitivity and specificity [3]. The unique properties of CQDs, such as their small size, large surface area, and abundant surface functional groups, contribute to their excellent performance in biosensing. These characteristics facilitate efficient biomolecular interactions, enhancing the sensitivity and selectivity of the biosensors. Additionally, CQDs can be easily functionalized with various biomolecules, such as antibodies, enzymes, and nucleic acids, allowing for specific recognition and capture of target analytes [4].

The applications of CQDs in biosensors for disease detection are extensive. They have been employed in the detection of a wide range of biomarkers, including proteins, nucleic acids, metabolites, and infectious agents. CQDbased biosensors have demonstrated exceptional performance in detecting diseases such as cancer, infectious diseases, cardiovascular disorders, and neurodegenerative conditions. The ability of CQDs to provide rapid and sensitive detection of disease biomarkers offers great potential for early diagnosis, monitoring disease progression, and personalized medicine. Moreover, CQDs have shown promise in point-of-care diagnostics, where their ease of use, portability, and rapid response time make them suitable for decentralized healthcare settings. Their integration into portable devices, such as paper-based or handheld biosensors, has facilitated the development of simple and costeffective diagnostic tools [5].

Conclusion

Carbon Quantum Dots (CQDs), with their properties and applications in biosensors for disease detection, present a remarkable opportunity to transform diagnostics. CQDs are potent instruments for the precise and sensitive detection of disease biomarkers thanks to their optical properties, biocompatibility, and functionalization capabilities. Because of their adaptability, CQDs can be used to create biosensors for a variety of diseases, allowing for approaches to personalized medicine and early detection. However, CQD synthesis optimization, stability enhancement, and performance enhancement in complex biological samples require additional research. We can anticipate illuminating disease detection and making significant progress toward enhancing healthcare outcomes thanks to on-going advancements in CQD-based biosensing technologies.

Acknowledgement

None.

Conflict of Interest

There are no conflicts of interest by author.

References

1. Manikandan, Velu and Nae Yoon Lee. "Green synthesis of carbon quantum dots and their environmental applications." Environ Res 212 (2022): 113283.

Google Scholar, Crossref, Indexed at

2. Ramachandran, Rani Puthukulangara, Chelladurai Vellaichamy and Chyngyz Erkinbaev. "Smart nano-biosensors in sustainable agriculture and environmental applications." In Food, Medical, and Environmental Applications of Nanomaterials (2022): 527-542.

Google Scholar, Crossref, Indexed at

3. Behboudi, Hamidreza, Mehrab Pourmadadi, Meisam Omidi and Moones Rahmandoust, et al. "Cu-CDs as dual optical and electrochemical nanosensor for βME detection." Surf Interfaces 29 (2022): 101710.

Google Scholar, Crossref, Indexed at

4. Namdari, Pooria, Babak Negahdari and Ali Eatemadi. "Synthesis, properties and biomedical applications of carbon-based quantum dots: An updated review." Biomed Pharmacother 87 (2017): 209-222.

Google Scholar, Crossref, Indexed at

5. Zamani, Mahsa, Mehrab Pourmadadi, SA Seyyed Ebrahimi and Fatemeh Yazdian, et al. "A novel labeled and label-free dual electrochemical detection of endotoxin based on aptamer-conjugated magnetic reduced graphene oxide-gold nanocomposite." J Electroanal Chem 908 (2022): 116116.

Google Scholar, Crossref, Indexed at