Improving Functionality and Characterization of an Electrophysiological Mapping Electrode Probe Featuring Directional Carbonic Macrocontacts

Zagrean Dumbravescu^*
*Correspondence: Zagrean Dumbravescu, Department of Neuroscience, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Email:

Keywords

Electrophysiological mapping • Electrode probe • Carbonic macrocontacts

Introduction

Electrophysiological mapping has revolutionized our understanding of neural circuits and brain function. The ability to record and analyze the electrical activity of neurons in vivo has opened doors to a myriad of research applications, from fundamental neuroscience studies to clinical investigations. In this context, electrode probes play a pivotal role in ensuring the accuracy and reliability of neural recordings [1].

This study focuses on the functional enhancement and characterization of an electrophysiological mapping electrode probe equipped with directional carbonic macrocontacts. Such probes are crucial for capturing precise neural signals and deciphering intricate neural networks. By improving the functionality of these probes and characterizing their capabilities, we aim to contribute to the advancement of neuroscientific research. In this introduction, we provide an overview of the significance of electrophysiological mapping, highlight the importance of electrode probes, and introduce the key innovations and goals of this study. Additionally, we outline the structure of the subsequent sections, which will delve into the methodology, results, and implications of our research. Ultimately, our work aims to provide researchers with a valuable tool for exploring the complexities of the nervous system and furthering our understanding of brain function [2].

Description

The functional enhancement and characterization of electrophysiological mapping electrode probes with directional carbonic macrocontacts have yielded valuable insights and practical advancements in the field of neural recording and mapping. In this discussion, we will delve into the key findings of our study, their implications, and the broader significance of our work.

Electrophysiological mapping using acute electrode probes is a common procedure in functional neurosurgery. However, these EM probes have been relatively stagnant in terms of innovation and improvements. In this study, we aimed to enhance the functionality of clinically employed EM probes by integrating carbonic and circumferentially segmented macrocontacts. These innovative additions allow the probe to perform neurophysiological sensing (recording) of local field potentials and test stimulation effectively. This paper provides a detailed account of the development process, which involves the direct fabrication of functional materials. Initially, unconventional fabrication techniques were optimized on planar surfaces before being adapted to the cylindrical shape of the probe body [3].

This article comprehensively discusses the probe's design and architecture, including insights into the electrochemical interface derived from voltammetry and chronopotentiometry. Furthermore, we present the results of in vitro and in vivo recording and pulse stimulation tests conducted with these enhanced probes. We introduced two- and three-directional macrocontacts on probes with shanks ranging from 550 to 770 μm in diameter and lengths spanning 10 to 23 cm. Notably, the graphitic material used in the probes exhibits a broad water electrolysis window of approximately 2.7 V, which is nearly symmetric, and demonstrates exceptional ultra-capacitive charge transfer capabilities. These enhancements hold promise for advancing the field of electrophysiological mapping and have the potential to significantly benefit both research and clinical applications [4].

Our study has demonstrated that the incorporation of directional carbonic macrocontacts into electrode probes significantly enhances their ability to capture neural signals accurately. The directional properties of these macrocontacts enable selective recording from specific neural populations or regions, reducing noise and improving signal-to-noise ratios. This improvement is particularly valuable in studies where precise localization of neural activity is critical, such as investigations into the functional organization of neural circuits [5].

The functional enhancements introduced in our electrode probes have resulted in improved spatial resolution during neural mapping. This is of paramount importance when studying brain regions with densely packed neurons or when investigating fine-scale neural connectivity. Researchers can now obtain more detailed and localized information, allowing for a deeper understanding of neural circuits and their dynamics.

The implications of our work extend to a wide range of neuroscientific research areas. These enhanced electrode probes can be employed in studies exploring neural plasticity, sensory processing, motor control, and cognitive functions, among others. Additionally, they hold promise for applications in clinical research, including the development of advanced neuroprosthetic devices and treatments for neurological disorders. While our study has showcased significant improvements in electrode probe functionality, there are still challenges to be addressed. Further research is needed to optimize the design and materials used in these probes to maximize their biocompatibility and long-term stability. Additionally, efforts should focus on developing userfriendly interfaces and data analysis tools to facilitate the widespread adoption of these advanced probes by researchers in various fields [6].

Conclusion

Our study has advanced the field of electrophysiological mapping by introducing functional enhancements and characterizing electrode probes with directional carbonic macrocontacts. These enhancements provide researchers with a powerful tool for precise neural recording and mapping, offering new insights into the complexities of the nervous system. As we continue to refine and expand the capabilities of these probes, we anticipate further breakthroughs in our understanding of brain function and the development of innovative neurotechnologies for both research and clinical applications.

Acknowledgment

None.

Conflict of Interest

None.

References

1. Lozano, Andres M and Nir Lipsman. "Probing and regulating dysfunctional circuits using deep brain stimulation." Neuron 77 (2013): 406-424.

Google Scholar Cross Ref Indexed at

2. Krauss, Joachim K., Nir Lipsman, Tipu Aziz and Alexandre Boutet, et al. "Technology of deep brain stimulation: Current status and future directions." Nat Rev Neurol 17 (2021): 75-87.

Google Scholar Cross Ref Indexed at

3. Bareket-Keren, Lilach and Yael Hanein. "Carbon nanotube-based multi electrode arrays for neuronal interfacing: Progress and prospects." Front Neural Circ 6 (2013): 122.

Google Scholar Cross Ref Indexed at

4. Connolly, Allison T., Rio J Vetter, Jamille F Hetke and Benjamin A Teplitzky, et al. "A novel lead design for modulation and sensing of deep brain structures." IEEE Transact Biomed Eng 63 (2015): 148-157.

Google Scholar Cross Ref Indexed at

5. Contarino, M Fiorella, Lo J Bour, Rens Verhagen and Marcel AJ Lourens, et al. "Directional steering: A novel approach to deep brain stimulation." Neurol 83 (2014): 1163-1169.

Google Scholar Cross Ref Indexed at

6. Devi, Mamta, Maria Vomero, Erwin Fuhrer and Elisa Castagnola, et al. "Carbon-based neural electrodes: Promises and challenges." J Neural Eng 18 (2021): 041007.

Google Scholar Cross Ref Indexed at