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Incidence and Determinants of Attrition among HIV Infected Patients Receiving Antiretroviral Therapy in Dessie Referral Hospital, Ethiopia: Retrospective Follow up Study
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Journal of AIDS & Clinical Research

ISSN: 2155-6113

Open Access

Research Article - (2021) Volume 12, Issue 11

Incidence and Determinants of Attrition among HIV Infected Patients Receiving Antiretroviral Therapy in Dessie Referral Hospital, Ethiopia: Retrospective Follow up Study

Girum Shibeshi Argaw1, Aynishet Adane Mariyam2, Adhanom Gebreegziabher Baraki3 and Tilahun Yemanu Birhan3*
*Correspondence: Tilahun Yemanu Birhan, Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine & Health Sciences, University of Gondar, Gondar, Ethiopia, Tel: + 251925978489, Email:
1Department of Nursing, College of Medicine and Health Science, Jigjiga University, Jigjiga, Ethiopia
2Department of Internal Medicine, School of Medicine, College of Medicine & Health Sciences, University of Gondar, Gondar, Ethiopia
3Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine & Health Sciences, University of Gondar, Gondar, Ethiopia

Received: 08-Nov-2021 Published: 07-Dec-2021 , DOI: 10.37421/2155-6113.2021.12.860
Citation: Argaw, Girum Shibeshi, Aynishet Adane Mariyam, Adhanom Gebreegziabher Baraki and Tilahun Yemanu Birhan. “Incidence and Determinants of Attrition among HIV Infected Patients Receiving Antiretroviral Therapy in Dessie Referral Hospital, Ethiopia: Retrospective Follow Up Study.” J AIDS Clin Res 12(2021): 860.
Copyright: © 2021 Argaw GS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Antiretroviral treatment (ART) scale-up has resulted in significant reductions in HIV-related morbidity and death. However, attrition from ART care remains a major public health concern, and it has been highlighted as one of the most important reportable factors in evaluating the success of ART programs. However, there are few researches in the subject region that indicate the incidence and predictors of it. As a result, the goal of this study was to determine the rate of attrition and predictors of attrition among adult HIV patients who started antiretroviral therapy (ART) at Dessie Referral Hospital.

Method: An Institution-based retrospective follow up study was conducted from January 2015 to October 2019. A sample of 565 patients was selected using simple random sampling and we were use data extraction checklist for extracting data from patient charts. The proportional hazard assumption was verified visually and using the Schoenfeld residual global test; a bi-variable cox regression analysis was performed. In the bivariable study, variables having a p-value of 0.2 were fitted to the multivariable cox regression analysis.

Result: A total of 565 adult HIV patients on ART were included in the analysis, The Incidence rate of over all attrition in this study was 14.2 per 100 person-year (95% CI; 12.2-16.6). Having ambulatory functional status, (aHR=2.08; 95% CI (1.29-3.33)), a patient who did not disclosed their HIV status (aHR=2.27; 95%CI; 1.39-3.69), presence of Comorbidity throughout the follow-up time 2.11 (aHR-2.11;95%CI (1.38-3.23)), patients who didn’t take CPT prophylaxis 1.68 (aHR-1.68;95%CI (1.34-2.49)),fair and poor level of adherence 2.75 (aHR=2.75; 95%CI (1.75-4.30)) and 2.16 (aHR=2.16; 95%CI (1.39-3.36)) respectively were significant predictors of attrition.

Conclusion: In this study, the incidence of attrition was high. Patients on ART who did not disclose their HIV status, those who were in fair and poor level of adherence, those did not take CPT prophylaxis,, ambulatory functional status, patients who had co morbidity at enrollment, were at higher risk of Attrition. Therefore, intensive monitoring, reminders, surveillance, and tracking mechanisms aimed at this higher-risk population would reduce ART attrition.

Keywords

HIV /AIDS • Attrition • ART •. Ethiopia

Abbreviations

HAART: Highly Active Antiretro Viral Therapy • HIV: Human Immunodeficiency Virus • CD4: Cluster Differentiation Four • AIDS: Acquired Immune Deficiency Syndrome • cART: Combination Antiretroviral Therapy • PLWH: People Living with HIV • BMI: Body Mass Index • CIFs: Cumulative Incidence Functions • CPT: Cotrimoxazole Preventive Therapy • ETB: Ethiopian Birr; HIV: Human Immune Deficiency Virus; INH: Isoniazid Preventive Therapy • LTFU: Lost To Follow Up • OIs: Opportunistic Infections • PTB: Pulmonary Tuberculosis • TB: Tuberculosis • WHO: World Health Organization • FDC: Fixed Dose Combination • FMOH: Federal Ministry of Health • HAART: Highly Active Antiretroviral Therapy • HBV : Hepatitis B Virus • HCV: Hepatitis C Virus • HTS: HIV Testing Services • cHR: Crude Hazard Ratio • aHR: Adjusted hazard ratio • CI: Confidece interval

Introduction

The Human Immunodeficiency Virus (HIV/AIDS) continues to be a serious public health issue in Sub-Saharan Africa, claiming the lives of millions of people in their prime and leaving millions of children orphaned [1]. More than 74.9 million individuals have been infected with the Human Immunodeficiency Virus (HIV) since the epidemic began among those around 32.0 million people dying from HIV; At the end of 2018, 37.9 million people worldwide were living with HIV [1-4]. Antiretroviral treatment has dramatically decreased HIV-infected patients' mortality and extended their life expectancy, but its success still hinges on continuous patient follow-up [5-8]. Attrition among HIV-positive patients is linked to adherence to Antiretroviral Therapy (ART) and is becoming more of an issue in Sub-Saharan Africa as the ART program expands, resulting in a decrease in the health professional-to-patient ratio [9-12]. It also accounts for the bulk of all attrition, and the problem of attrition may be solved if the relevant causes are identified and patients are tracked properly [13,14].

Indeed, attrition has been highlighted by the World Health Organization (WHO) as one of the major factors in determining the effectiveness of an ART program [15]. Scaling up HIV management has been hampered by mortality and loss of follow-up in the ART program [3,16,17].Attrition rates in Asia and Sub-Saharan Africa have been reported to range from 6.2% to 35% [6,7,10,11,13,18-22]. In addition, the amount of attrition varies by area in Ethiopia ranging from 9.8% to 33% [5,8,14,20,23-29].

According to a systematic study done in low-resource settings, including Ethiopia, the major predictors of attrition were patients with advanced HIVdisease progression marked by Body Mass Index (BMI) <18 kg/m2, baseline CD4counts<200 cells/mL [30,31], WHO stage - III and IV, non-disclosure of HIV serostatus [8,19,21,24,27], who had an opportunistic infection at baseline, who were not start CPT, reside in greater than 10 km far from health institution, poorer level of functionality, male sex [16,22,27,32-34] younger age and having lower levels of education [35-37]. Other research has found that people who begin ART with a higher baseline CD4, ambulatory functional status [28,29,38,39], working functional status, a secondary or higher level of education are more likely to drop out [31,35-37]. Despite the risk factors of attrition among people who are on ART were researched, some settings which provide HIV/AIDS care and treatment services for a high number of movable population like Dessie Hospital were not fully addressed. However, HIV/AIDSrelated mortality and failure to follow up remain a major public health concern in the region. As a result, local data on risk factors for mortality among HIV/ AIDS patients on ART is needed to offer evidence for organizations working on HIV/AIDS and ART at the national, regional, and district levels. Hence, this study aimed to determine the incidence and predictors of attrition among adult HIV/AIDS patients who were on ART at Dessie Hospital, Ethiopia.

Methods

Study design and setting

An institutional-based Retrospective follow-up study was conducted in Dessie referral hospital between January 1 2015 to December 30 2019 G.C among Adult HIV patients who were on ART. The hospital is found in Dessie town which is located 354 km from the capital of Ethiopia Addis Ababa. According to the city, administrative health office the total population of the town is 218,473. About 102,375 (46.86%) are males and 116,098 (53.14%) are females. The hospital is a leading referral hospital in northern central Ethiopia serving an estimated five million people. ART service is one of the services given by this hospital and a summary of medical records of the hospital shows that currently, there are 7,542 patients on ART follow up among these 6,279 are adults.

Sampling technique and data collection procedure

Adult HIV-positive patients who were on ART at Dessie referral Hospital ART clinic and who enrolled in treatment from January 1, 2015, to December 31, 2019, and Age > 15years at least one follow-up visit were included in this study. However, a patient transferred in with incomplete baseline data and patients who are unknown initiation date of treatment has been excluded. Records of study participants were filtered first from the database according to their entry time to the follow-up, next patients were selected using age and eligibility criteria then we were given a unique number for the remaining records and select each record for our sample using computer-generated random number. The optimum sample size was 565 estimated by using the power cox command of Stata 14 software.

Variables and operational definitions of the study

Our primary outcome was attrition, which combines two mutually exclusive events LTFU and death (mortality).

LTFU was defined as patients who had missed the next clinic visit or pharmacy refill appointment to the same Health Facility at most 3 consecutive months after the last scheduled visit [20].

Death was defined as patients recorded as dead on the patient’s exit form or whose outcome is recorded as death on the follow-up chart [20]. A patient was classified as censored if he/she had a formally recorded transfer to another health institution or still on follow up at this Dessie referral hospital at the end of the study period. The predictor variables assessed were baseline sociodemographic factors (age sex, marital status, occupational status, educational status, residence, religions, and distance from health facility, disclosure status, and caregiver status). Clinical and treatment-related characteristics (baseline CD4 count, baseline WHO stage, INH prophylaxis, CPT prophylaxis, viral load, status of OI at enrollment, baseline functional status, BMI, baseline & recent adherence level, current TB status).according to WHO ART treatment guideline ART adherence level defined as Good (G): when a patient adherence level is ≥ 95% (of 30 doses ≤ 2 doses missed).Fair (F): when a patient adherence level 85-94% (of 30 doses 3-4 doses missed).Poor (P): when a patient adherence level is ≤ 84% (of 30 doses ≥ 6 doses missed).Disclosed was defined as disclosure of the status that is being HIV positive at least for one individual [17] Functional status was classified as Ambulatory: If the patient able to perform Activity of daily life but not able to work. Bedridden: Not able to perform Activities of daily life [40] The data were collected from the patient charts by one health officer and four clinical nurses by using a data extraction sheet which was designed based on study objectives. To assure the data quality, training was given for the data collectors and the supervisor about the ways of extracting the data based on the study objectives. The tool was also pretested and the data were checked for steadiness and completeness on daily basis by the principal investigator.

Data processing and analysis

Visual examination, performing frequencies and cross-tabulations, verifying missing values, and checking out of range values were used to clean the data before it was coded and put into Epi-data 3.1, which was subsequently exported to STATA 14. The characteristics of the study participants were described using descriptive statistics such as proportions, medians, tables, graphs, and charts. We used the Schoen field residual global test to fit the Cox regression model after confirming the proportional hazard assumption visually (Figure 1). The Kaplan-Meier test was used to estimate survival time, and the Log-rank test was performed to determine whether there was a significant difference in survival time across various categories of variables. To find variables correlated to attrition, a bi-variable cox regression analysis was used. In the bivariable analysis, factors having a p-value <0.2 were fitted to the multivariable Cox regression analysis once again (Figure 2). To determine the strength of the association, both crude and adjusted hazard ratios with the equivalent 95% Confidence Interval (CI) were computed. Variables with a P-value <0.05 were considered statistically significant in multivariable analysis.

aids-clinical-research-adult

Figure 1. The proportion of survival status among adult HIV patients on ART in Dessie referal Hospital between January 1, 2015, and December 31, 2019.

aids-clinical-research-adequacy

Figure 2. Cox Snell residual graph for checking model adequacy of Cox Model.

Results

Baseline socio-demographic characteristics of study participants

A total of 565 clients enrolled in ART care were included in the final analysis. Nearly half, 283 (50.09%) of the study participants were females. The median age of 37 (IQR = + 17) years. Of the total, 292 (51.68%) were married and the majority, 263 (46.55%) of study participants were

Muslim concerning educational status, 176 (31.15%) of participants had a primary level of education. Most of the study participants 443 (73.39%), disclosed their HIV status, and 449 (88.32%) of subjects had caregivers (Table 1).

Table 1: Base line socio-demographic characteristics for adult HIV patients on ART in Dessie Referral Hospital between January 01, 2015 and December 31, 2019.

Variables Category Frequency Percentage (%)
Sex Male 282 49.91
Female 283 50.09
Age 15-24 61 10.8
25-34 156 27.61
35-44 211 37.35
45 137 24.25
Marital status Single 93 16.46
Married 292 51.68
Divorced 101 17.88
Widowed 79 13.98
Residence Urban 345 61.06
Rural 220 38.94
Distance from the health facility Below 10 km 291 51.5
10 km and above 274 48.5
Educational status No education 130 23.01
Primary 176 31.15
Secondary 161 28.5
Tertiary and above 98 17.35
Occupation Unemployed 95 16.81
Daily laborer 114 20.18
Governmental-employee 108 19.12
Self-employee 103 18.23
Others* 145 25.66
Religious Orthodox 212 37.52
Muslim 263 46.55
Others** 90 15.93
Disclosure status (n=558) Disclosed 443 73.39
Not disclosed 115 20.61
Care giver (n=564) Yes 499 88.32
No 65 11.5

Clinical and treatment-related characteristics

From a total of 565 study participants enrolled in ART care, about 240 (42.93%) were linked to care with a baseline CD4 count between 201-350cells/ ml. The median CD4 count of the participants was 289 (IQR=213-397 cells/ml) and a total of 249 (44.07%) participants were at WHO stage II. More than fourfifth (82.49%) of the patients had been started on Cotrimoxazole prophylaxis therapy. The majority (95.8%) of patients was screened for TB, of which 19.7% were co-infected (Table 2).

Table 2: Clinical and treatment-related characteristics of adult HIV patients on ART in Dessie referral hospital between January 01, 2015 and December 31, 2019.

Variables Categories Frequency Percentage (%)
Baseline CLD4 count ≤200 120 21.47
201-350 240 42.93
>350 199 35.6
Baseline WHO stage Stage I 161 28.49
Stage II 249 44.07
Stage III/ IV 155 27.4
Last known WHO stage Stage I 139 24.6
Stage II 320 56.64
Stage III/ IV 106 18.76
CPT prophylaxis Yes 459 82.41
No 98 17.59
INH prophylaxis Yes 337 68.08
No 158 31.92
OI at enrollment Yes 237 42.25
No 324 57.75
Types of OI  at enrollment TB 112 47.25
Toxoplasmosis 13 5.48
Skin infections 12 5.06
Chronic diarrheal diseases 16 6.75
Others** 84 35.44
TB screening status Positive 111 19.68
Negative 437 77.48
On treatment 16 2.84
Current TB status/last known/ Positive 45 7.96
Negative 520 92.04
Functional status Working 431 76.28
Ambulatory 106 18.76
Bedridden 28 4.96
BMI <18.5 158 27.96
18.5-24.9 325 57.52
≥25 82 14.52
last known adherence Good 369 65.43
Fair 128 22.7
Poor 67 11.88
Hgb/Baseline/ <8 23 4.32
8-10.9 158 29.7
11-12.9 126 23.68
≥13 225 42.29
Types of regimen at start 1c(AZT-3TC-NVP) 13 2.3
1d (AZT-3TC-EFV) 15 2.65
1e (TDF-3TC-EFV) 418 73.98
1j (TDF-3TC-DTG) 31 5.49
1f /1h/1g/(Others****) 88 15.58

Incidence of attrition

Of the 565 adults who initiated ART and followed for 5 years, 323 (57.2%) were retained and on active follow-up while 82 (14.51%) were formally transferred to other health facilities. Eighty-six (15.22%) were reported dead and 74 (13.10%) were LTFU (Figure 3). The overall attrition was 28.3% (95% CI: 24.64, 32.22). The 565 adults on ART contributed a total of 1,127 person-years of observation (Pyo).The incidence rate for LTFU, Dead, and overall attrition was 6.6 per 100 person-year (95%CI, 5.23-8.24), 7.6 per 100 person-year (95%CI 5.2-11.4), and 14.2 per 100 person-year (95%CI, 11.2- 20.6) respectively. The attrition by 6 and 12 months were 37 (22.9% [95% CI, 18.0–24.1]) and 35 (21.6% [95% CI, 19.9 – 23.3]).

aids-clinical-research-hazard

Figure 3. Plot of ln (-ln (survival probability)) versus ln (survival time) for assessing proportional hazard of Care giver status and Comorbidity status of patients at Dessie Referal Hospital, Ethiopia, from January 1, 2015 to December 31, 2019.

Predictors of attrition among adult HIV patients on ART

The survival experience of patients was analyzed non-parametrically using the Kaplan-Meir survival curve (Figure 4) against several categories of predictors and log-rank test was used to check the significant association (p-value<0.05) between each predictor variables along with the outcome variable (Figure 5).The log-rank test revealed a significant difference between BMI status, CPT, IPT, comorbidity status, sex, marital status, adherence level, baseline WHO stage, disclosure status, caregiver, educational status, residence, OI, and distance from the health facility. These variables were also crudely associated with HIV patient attrition at a 20% level of significance.

aids-clinical-research-probability

Figure 4. Cumulative survival probability of patients on ART in Dessie referral Hospital from January 01/2015 to December 31/2019.

aids-clinical-research-prophylaxis

Figure 5. Survival curves (KM curves) for the follow-up of adults on ART according to their BMI level, CPT prophylaxis, sex & co-morbidities at starting of ART.

After fitting multivariable analysis, variables such as adherence level, ambulatory functional status, CPT, comorbidity, and disclosure status were found to be significant predictors for Attrition at a 5% level of significance. Among the significant predictors of Attrition being ambulatory functional status increased the risk of attrition by 2.08 (HR=2.08; 95%CI (1.29-3.33)) times compared with those were on working functional status. The hazard of attrition was higher among patients who did not disclose their HIV status by 2.27 (HR=2.27; 95%CI; 1.39-3.69) times compared with their counterparts.

The presence of Comorbidity throughout the follow-up time increases the hazard of Attrition by 2.11 (HR-2.11; 95% CI (1.38-3.23)) times as compared to their counterparts. The hazard of Attrition was increased on patients who didn’t take CPT prophylaxis by 1.68 (HR-1.68; 95%CI (1.34-2.49)) times compared with the counterparts. Moreover, the hazards of Attrition among the fair and poor level of adherence were 2.75 (HR=2.75; 95%CI (1.75-4.30)) and 2.16 (HR=2.16; 95%CI (1.39-3.36)) times higher than those who have a good level of adherence respectively (Table 3).

Table 3: Bivariable and multivariable cox regression analysis for predictors of attrition among adult HIV patients on ART at dessiereferal Hospital between January 1, 2015, and December 31, 2019.

Variables Survival status Over all Attrition
  Censored(405) LTFU(74) Death(86) cHR(95% CI aHR(95%CI)
Sex
Female 223 19 41 1 1
Male 182 55 45 1.73 (1.25-2.38) 1.30 (0.91-1.86)
Marital status
Married 64 16 13 1 1
Single 232 23 27 1.53 (0.98-2.39) 0.73 (0.43-1.23)
Divorced 67 14 20 1.61 (1.05-2.45) 0.98 (0.61-1.55)
Widowed 42 21 16 2.44 (1.62-3.68) 1.34 (0.82-2.18)
Educational status
2nd & above 201 38 20 1 1
Primary 126 17 33 1.28 (0.88-1.87) 1.06 (0.68-1.68)
No education 78 19 33 2.12 (1.46-3.09) 0.89 (0.58-1.36)
Residence
Urban 264 38 43 1 1
Rural 141 36 43 1.93 (1.42-2.64) 1.12 (0.74-1.72)
Disclosure status
Disclosed 350 34 59 1 1
Not disclosed 55 40 27 3.51 (2.55-4.81) 2.27 (1.39-3.69)**
Care giver
Have care giver 381 54 64 1 1
No care giver 24 20 22 3.52 (2.47-5.02) 1.01 (0.58-1.73)
Distance from HF
Below 10 km 222 34 35 1 1
Above 10 km 183 40 51 1.53 (1.12-2.09) 0.89 (0.58- 1.34 )
Baseline CD4 count (In cells/ml)
>350 161 22 16 1 1
201-350 58 37 45 2.02 (1.37-2.97) 1.22 (0.73 - 2.05)
≤200 81 15 24 1.81 (1.16-2.83) 1.28 (0.83 - 1.98)
Adherence (last known)
Good 308 33 28 1 1
Fair 66 30 32 4.36 (2.96-6.42) 2.75 (1.75-4.30)**
Poor 31 10 26 3.79 (2.57-5.59) 2.16 (1.39-3.36)**
TB screening status (at enrolment)
Negative 332 52 53 1 1
Positive 65 20 26 1.99 (1.40-2.82) 1.18 (0.70-1.99)
On treatment 7 2 7 2.43 (1.23-4.80) 1.35 (0.58-3.14)
Body mass index (BMI) in kg/m2
≥25 94 19 45 1 1
18.5-24.9 252 37 36 0.75(0.47-1.19) 2.42(0.87-4.29)
<18.5 59 18 5 1.65(1.02-2.65) 1.44(0.67-1.95)
CPT prophylaxis
No 72 28 16 1 1
Yes 330 42 69 1.74(1.22-2.47) 1.68(1.14-2.49)**
Functional status (Baseline)
Working 363 33 35 1 1
Ambulatory 35 37 34 5.98 (4.27-8.37) 2.08 (1.29-3.33)**
Bedridden 7 4 17 6.96 (4.25-11.41) 1.96 (0.95-4.07)
WHO Stage (Baseline)
Stage one 143 8 7 1 1
Stage two 202 23 24 1.68 (0.94-3.01) 1.45 (0.76-2.76)
Stage 3 or 4 60 43 55 11.19 (5.83-21.51) 2.70 (0.95-6.94)
Comorbidity status
No 369 56 67 1 1
Yes 31 18 19 3.05 (2.11-4.41) 2.11 (1.38-3.23)**
OI (atenrollment)
No 250 36 38 1 1
Yes 151 38 48 1.56 (1.14-2.12) 0.57 (0.35-1.87)

Discussion

The incidence and determinants of attrition among adult HIV/AIDS patients on ART follow-up were investigated in this study. Several factors were included in this cox regression model to explain variance in HIV/AIDS patient attrition. The overall attrition rate was 14.2 per 100 person year in line with studies conducted in Kenya [11] (14.1/100 py) and Northern Ethiopia [14] (14.9/100py). This might be owing to the consistency in the quality of treatment provided to HIV/AIDS patients in these hospitals based on ART recommendations. However, the finding of this study is higher than other studies conducted in Swaziland [15], Zimbabwe [41], and other parts of Ethiopia [36,42-44]. This discrepancy might be due to the only ART center in the town which serves many patients, there may be overloading of patient flows resulting in difficulty in providing adequate health services and access, and ultimately, patient discontent. The other possible explanation could be variations in study design, patient follow-up periods, and definitions of LTFU and attrition might be another factor for the difference. LTFU is defined as a patient who has been missing for at least 90 days, while in studies in Sub-Saharan Africa [45], India [46], and Ethiopia [36,43,44], LTFU is defined as a patient who has been missing for at least 180 days. The finding of this study is lower than other studies conducted in Latin America, South Africa, Southern Ethiopia [47-49]. The discrepancy might be due to variations in study design and the operationalization of terms, majority of the studies defined attrition as a combination of (LTFU, death, and transferred out) which could inflate the attrition rate.

In this study patients who were not taking CPT were more likely to be attritted in ART care similar with other studies performed in Myanmar, India, and Tepi [6,31,49].This might be because CPT, given for the prevention of bacterial infections [17,40,50], improves people's health by keeping them from becoming ill as often. In contrast, the patients who do not take CPT more susceptible to a variety of opportunistic infections and they may have such diseases and either develop drug toxicity due to drug-drug interaction or they may prefer to go to Traditional healers (Holly water) by discontinuing such burden of drugs and finally end up with Lost to follow up or Death leads to Attrition [16,39]. Patients who did not disclose their HIV/AIDS status were 2.27 times more likely to undergone Attrition from the treatment Program as compared to their counterparts, similar outcomes are published in sub-Saharan Africa, Tepi [49,51]. This might be due to the social support they receive after declaring their sexual orientation; it will decrease the likelihood of attrition because staying on treatment necessitates extensive support and care from many sectors of the community [52]. Patients in ambulatory functional status had a 2.08 higher risk of attrition than those in working functional status. The social, economic, and financial effects induced by their incapacity to work may be one reason why ambulatory patients are more prone to undergo attrition [42,47,53].

When compared to their contemporaries, patients with co-morbidities had a 2.11 times higher chance of attrition similar to a mixed model study done in Uganda and Kenya [54]. Comorbidities are additional chronic diseases that may jeopardize the health of HIV-positive people [3,29], these patients are forced to take more medicine, resulting in pill load and attrition from therapy. Individuals may be overburdened by these numerous illness conditions, and their HIV prognosis may deteriorate as a result, patients may be lost and/or die [40,50].When comparing patients with fair or poor adherence to those with strong adherence, the risk of attrition was more than twice as high. This finding is in agreement with studies conducted in Kembata Hadiya and Adama [55,56], suggesting that patients with poor adherence to ART medications are more likely to stop taking them [28,29,39],resulting in treatment failure and mortality [54].

The retrospective aspect of the investigation, which lacks completeness of certain potentially relevant variables such as drug use, might be a possible drawback of this study. There may be changes in these characteristics over time because the study utilized baseline socio-demographic and clinical data.

Conclusion

The rate of attrition was high in this study. Patients on ART who did not disclose their HIV status, poor level of adherence, those who did not take CPT prophylaxis, ambulatory functional status, and who had co-morbidity were at higher risk of Attrition. As a result, paying greater attention and closely following up on these high-risk populations in order to reduce attrition.

Declaration

Ethical approval and consent to participate

Ethical approval has been received from the Institutional Review Board (IRB) of the University of Gondar, College of Medicine and Health Science. Supportive letter was obtained from Dessie Refereral Hospital administration office to collect the data. All study participants are given written information about the research project, its benefits, and risks. They are informed that they have the choice to leave the study at any time. Prior to the intake information, written and verbal informed consent was received. Regarding ethical issues, this study protocol was conducted in accordance with the World Medical Association (WMA) Declaration of Helsinki.

Consent for Publication

Not applicable

Availability of Data and Materials

The data set analyzed for this study is not publicly available due to restriction in the IRB consent but may be available from the corresponding author based on reasonable request.

Authors Contributions

GSA: participated in conceptualization, data collection, data analysis, and original drafting of proposals; AAG, AGB, and TYB contributed on data analysis, original drafting, visualization, and validation for the manuscript. All authors reviewed and approved the final version of the manuscript.

Competing Interests

Authors declare that they have no conflict of interest

Funding

There is no funding available for this research.

Acknowledgments

We appreciate the assistance and permission to perform the study from Dessie Referral Hospital administration personnel and chart room staff. We also appreciate the clinicians who work in the ART clinic as well as the ART data managers for providing us with useful information. Finally, we'd want to express our gratitude to the data collectors and supervisor for their cooperation and dedication.

References

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