Investigating Immunization Related Occurrences: Using Scientific Inquiry

Andrew Pollard^*
*Correspondence: Andrew Pollard, Department of Paediatrics, University of Oxford, Oxford, UK, Email:

Keywords

Covaxin • Covishield • COVID-19 vaccines

Introduction

Vaccines have emerged as powerful tools in the global fight against the COVID-19 pandemic. However, the occurrence of vaccine-related incidents has led to concerns and raised questions about their safety and effectiveness. In this article, we delve into the complexities surrounding vaccine-related incidents, with a specific focus on Covaxin and Covishield, two widely used COVID-19 vaccines. By examining the scientific evidence, exploring incident reports, and analyzing regulatory responses, we aim to unravel the intricacies of these incidents and restore public confidence in these vaccines. Through rigorous scientific inquiry and transparent communication, we strive to provide a comprehensive understanding of the vaccine-related incidents associated with Covaxin and Covishield [1].

Description

Before delving into vaccine-related incidents, it is essential to understand the characteristics and development of Covaxin and Covishield, the two primary COVID-19 vaccines used in many countries. Covaxin, developed by Bharat Biotech in collaboration with the Indian Council of Medical Research (ICMR), is an inactivated whole-virus vaccine. It uses a deactivated form of the SARS-CoV-2 virus to stimulate an immune response in vaccinated individuals. Covishield, developed by Oxford University and AstraZeneca, is a viral vectorbased vaccine. It uses a harmless adenovirus, modified to carry the genetic material of the spike protein of the SARS-CoV-2 virus, to trigger an immune response. This section explores specific vaccine-related incidents associated with Covaxin and Covishield, examining the reported adverse events and the subsequent investigations and regulatory responses. Reports of anaphylactic reactions following Covaxin administration have raised concerns. Anaphylaxis is a severe allergic reaction that can occur rarely after vaccination [2].

Instances of thrombosis (blood clot formation) and thrombocytopenia (low blood platelet count) after Covaxin vaccination have been reported, although the incidence appears to be extremely rare. Cases of a rare clotting disorder called Thrombosis with Thrombocytopenia Syndrome (TTS) have been associated with Covishield. This condition involves blood clots combined with low platelet levels. VIPIT is a condition similar to TTS and has been reported following Covishield vaccination. It is characterized by blood clots and low platelet counts. Following the occurrence of vaccine-related incidents, investigations are conducted, and regulatory agencies respond to ensure public safety. This section discusses the investigations and responses related to Covaxin and Covishield incidents [3].

Incidents are thoroughly investigated to understand the underlying mechanisms and determine any causal relationship with the vaccines. Investigations typically involve medical assessments, laboratory analyses, and collaboration between healthcare professionals, regulatory bodies, and vaccine manufacturers. Regulatory agencies, such as the Indian Drug Regulator Authority (CDSCO) and the World Health Organization (WHO), closely monitor and evaluate vaccine-related incidents. They provide guidance, updates, and recommendations based on the available scientific evidence to ensure the safe use of vaccines. Restoring public confidence in vaccination programs is crucial to maintaining the effectiveness of public health interventions. This section explores strategies to rebuild trust in Covaxin and Covishield [4].

Open and transparent communication about vaccine-related incidents is vital. It includes providing clear and accurate information on the incidents, their investigation findings, and the steps taken to ensure vaccine safety. Enhancing vaccine safety monitoring systems and encouraging healthcare providers and individuals to report any adverse events can help identify and address incidents promptly. This fosters an environment of trust and demonstrates a commitment to public safety. Ongoing scientific research and studies play a pivotal role in comprehending vaccine-related incidents. Monitoring, investigating, and publishing findings related to adverse events associated with Covaxin and Covishield contribute to the understanding and continuous improvement of these vaccines [5].

Conclusion

Vaccine-related incidents associated with Covaxin and Covishield have raised concerns among the public. However, through rigorous scientific inquiry, transparent communication, and regulatory oversight, the complexities surrounding these incidents can be unraveled. By examining the reported adverse events, conducting investigations, and implementing regulatory responses, we can ensure public confidence in Covaxin and Covishield. Rebuilding trust in these vaccines is essential for maintaining successful vaccination programs and controlling the COVID-19 pandemic. By embracing scientific evidence, ongoing monitoring, and transparent communication, we can navigate vaccine-related incidents, improve public understanding, and foster a strong foundation for future vaccination efforts.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Hatherill, Mark, Richard G. White and Thomas R. Hawn. "Clinical development of new TB vaccines: Recent advances and next steps." Front Microbiol 10 (2020): 3154.

Google Scholar, Crossref, Indexed at

2. Matz, Keesha M., Andrea Marzi and Heinz Feldmann. "Ebola vaccine trials: Progress in vaccine safety and immunogenicity." Expert Rev Vaccine 18 (2019): 1229-1242.

Google Scholar, Crossref, Indexed at

3. Ahmed, Syed Faraz, Ahmed A. Quadeer and Matthew R. McKay. "Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies." Viruses 12 (2020): 254.

Google Scholar, Crossref, Indexed at

4. Pawelec, Graham. "Age and immunity: What is “immunosenescence”?." Exp Gerontol 105 (2018): 4-9.

Google Scholar, Crossref, Indexed at

5. Larson, Heidi J. "The state of vaccine confidence." Lancet 392 (2018): 2244-2246.

Google Scholar, Crossref, Indexed at