Kidney Cancer and their Therapeutic Studies

Albert Rikz^*
*Correspondence: Albert Rikz, Research Institute in Healthcare Science, Florida, USA, Email:

Introduction

Kidney cancer is a type of cancer that starts in the kidneys and spreads throughout the body. Your kidneys are two bean-shaped organs that are about the size of a fist apiece. They're behind your abdominal organs, on either side of your spine, with one kidney on each side. Renal cell carcinoma is the most frequent form of kidney cancer in adults. When cells in your kidneys alter and expand out of control, kidney cancer occurs. People who have kidney cancer may experience symptoms such as flank discomfort, high blood pressure, blood in their urine, and others. Surgery, chemotherapy, and radiation therapy are all options for treating kidney cancer. Early identification, like with other malignancies, is critical for successful therapy [1].

Description

A number of recently identified medications that impact the development of blood vessels and/or the proliferation of cancer cells are being explored as targeted therapy for kidney cancer. These clinical studies' findings suggest that these medications could be effective treatments for kidney cancer, and this is an area of rapidly changing science. Many targeted medicines and immunotherapies are being investigated for use as adjuvant therapy, or treatments given after the primary treatment(s) to reduce the chance of recurrence and eliminate any remaining cancer cells. Sunitinib, a targeted medication, reduced the return of cancer in patients with localised kidney cancer who were at high risk of recurrence following a nephrectomy. A radical nephrectomy is a surgery that removes the tumour, the entire kidney, and the surrounding tissue. If the disease has spread to neighbouring tissue and lymph nodes, a radical nephrectomy and lymph node dissection is required. The cancer-affected lymph nodes are removed during a lymph node dissection. If the cancer has spread to the adrenal gland or surrounding blood vessels, the surgeon will remove the adrenal gland as well as sections of the blood arteries during an adrenalectomy. When there isn't much good tissue left after a huge tumour, a radical nephrectomy is usually recommended. On its route to the heart, the renal tumour may develop directly inside the renal vein and enter the vena cava [2].

The tumour is surgically removed in a partial nephrectomy. After this sort of surgery, kidney function is preserved, and the risk of developing chronic renal disease is reduced. When surgery is not possible, research has indicated that partial nephrectomy is useful for T1 tumours. Newer surgical techniques that use a smaller surgical incision, or cut, have been linked to fewer adverse effects and a quicker recovery. During laparoscopic surgery, the surgeon makes multiple small cuts in the belly instead of a single bigger cut as in standard surgery. The surgeon next uses telescopic tools to entirely remove the kidney or perform a partial nephrectomy through these microscopic keyhole wounds. The surgeon may employ robotic devices to execute the procedure in some cases [3].

Immunotherapy, also known as biologic therapy, is a type of cancer treatment that works by boosting the body's natural defences. It improves, targets, or restores immune system function by using materials created by the body or in a laboratory. Interleukin-2 (IL-2) is a kind of interleuk (IL-2, Proleukin). IL-2 is an immunotherapy that has been utilised to treat kidney cancer in its later stages. It's a protein produced by white blood cells called a cytokine. It plays a role in immune system function, including tumour cell killing. Low blood pressure, extra fluid in the lungs, renal damage, heart attack, haemorrhage, chills, and fever are all serious side effects of high-dose IL-2. During therapy, patients may be required to stay in the hospital for up to ten days. However, some signs and symptoms may be present [4,5].

Conclusion

Chemotherapy is the use of medications to kill cancer cells by preventing them from growing, dividing, and producing new ones. A chemotherapy regimen, often known as a schedule, consists of a defined number of cycles administered over a set length of time. A patient may receive a single medicine at a time or a mixture of drugs at the same time. Although chemotherapy is useful for treating many types of cancer, most cases of kidney cancer are resistant to chemotherapy. Researchers are still looking for new drugs and pharmacological combinations. The combination of gemcitabine (Gemzar) with capecitabine (Xeloda) or fluorouracil (5-FU) can temporarily reduce a tumour in some people.

References

1. Kuusk, Teele, Yasmin Abu-Ghanem, Faiz Mumtaz and Thomas Powles, et al. "Perioperative therapy in renal cancer in the era of immune checkpoint inhibitor therapy." Curr Opin Urol 31 (2021): 262-269.

Indexed at, Google Scholar, Crossref

2. García-Bernal, David, Mariano García-Arranz, Rosa M. Yáñez and Rosario Hervás-Salcedo, et al. "The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy." Front Cell Develop Biol 9 (2021): 609.

Indexed at, Google Scholar, Crossref

3. Campbell, Steven C., Peter E. Clark, Sam S. Chang and Jose A. Karam, et al. "Renal mass and localized renal cancer: Evaluation, management, and follow-up: AUA guideline: Part I." J Urol 206 (2021): 199-208.

Indexed at, Google Scholar, Crossref

4. Wang, Ke-jie, Xiang-yu Meng, Jun-feng Chen and Kai-yun Wang, et al. "Emodin induced necroptosis and inhibited glycolysis in the renal cancer cells by enhancing ROS." Oxidative Med Cellular Longevity 20 (2021): 1-4.

Indexed at, Google Scholar, Crossref

5. Kim, Gi Beom, Oog-Jin Shon, Min-Soo Seo and Young Choi, et al. "Mesenchymal stem cell-derived exosomes and their therapeutic potential for osteoarthritis." Biol 10 (2021): 285.

Indexed at, Google Scholar, Crossref