Brief Report - (2023) Volume 6, Issue 5
Received: 02-Oct-2023, Manuscript No. jcnn-23-118858;
Editor assigned: 04-Oct-2023, Pre QC No. P-118858;
Reviewed: 16-Oct-2023, QC No. Q-118858;
Revised: 23-Oct-2023, Manuscript No. R-118858;
Published:
30-Oct-2023
, DOI: : 10.37421/2684-6012.2023.6.192
Citation: Gombuzel, Peter. “MicroRNAs: Signposts of Posttraumatic Epileptogenesis.” J Clin Neurol Neurosurg 6 (2023): 192.
Copyright: © 2023 Gombuzel P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Traumatic Brain Injury (TBI) is a significant public health concern, affecting millions of people annually and often resulting in long-term complications, including the development of Post-Traumatic Epilepsy (PTE). PTE, characterized by recurrent seizures following a TBI, poses a considerable burden on both affected individuals and the healthcare system. Early diagnosis and effective interventions are essential for preventing or mitigating PTE [1]. MicroRNAs (miRNAs), small non-coding RNA molecules that regulate gene expression, have emerged as promising biomarkers for a variety of neurological conditions. In recent years, research has shown that miRNAs may also serve as potential biomarkers of post-traumatic epileptogenesis, shedding light on the underlying mechanisms and providing insights into early diagnosis and therapeutic strategies. This paper explores the role of miRNAs as signposts of post-traumatic epileptogenesis, delving into their potential as diagnostic tools and the implications for understanding and managing this challenging condition [2].
Post-traumatic epileptogenesis is a complex process characterized by the development of epilepsy following a TBI. While the mechanisms driving this phenomenon are not fully understood, mounting evidence suggests that changes in gene expression play a crucial role. MicroRNAs, small molecules involved in post-transcriptional gene regulation, have been identified as potential key players in this context. Research has shown that TBI triggers a cascade of events, leading to altered miRNA profiles in the brain. These changes can influence the expression of genes involved in synaptic plasticity, inflammation and excitotoxicity, which are central to the development of epilepsy [3].
The appeal of miRNAs as biomarkers of post-traumatic epileptogenesis lies in their ability to reflect subtle changes in brain biology following TBI. They can be detected in various bodily fluids, including blood and cerebrospinal fluid, offering a minimally invasive means of assessing the risk of epileptogenesis. Additionally, miRNAs may serve as early indicators of TBI severity and the likelihood of PTE development, thereby guiding clinicians in providing more precise care and interventions. Recent studies have shown that specific miRNA signatures correlate with epileptogenesis and recurrent seizures in TBI patients. By identifying and quantifying these miRNA profiles, researchers and clinicians can gain insight into the risk and progression of PTE. Furthermore, manipulating miRNAs through targeted interventions may offer a promising avenue for the development of novel treatments to prevent or attenuate posttraumatic epileptogenesis [4,5].
The potential role of microRNAs as signposts of post-traumatic epileptogenesis offers new hope for early diagnosis and intervention in this challenging condition. By detecting changes in miRNA profiles following TBI, clinicians can gain valuable insights into the risk of PTE development and progression. The non-invasive nature of miRNA detection makes it an attractive tool for monitoring and predicting post-traumatic epileptogenesis in clinical practice. The journey toward understanding and effectively managing PTE continues to evolve, with microRNAs emerging as promising indicators of this condition. Further research into the specific miRNA signatures and their functional roles in post-traumatic epileptogenesis is necessary. The integration of miRNAs into clinical practice has the potential to transform our approach to TBI and PTE, enabling timely interventions, personalized care and, ultimately, improved outcomes for patients living with the consequences of traumatic brain injury.
Journal of Clinical Neurology and Neurosurgery received 2 citations as per Google Scholar report
