Molecular Mechanisms of Thyroid Cancer: From Oncogenes to Tumor Suppressors

Ilija Toemic^*
*Correspondence: Ilija Toemic, Department of Endocrinology,, “Iuliu Hatieganu” University of Medicine and Pharmacy, Romania, Email:

Introduction

Pesticides are chemical substances used to control pests and increase agricultural productivity. While they play a crucial role in food production, some pesticides have been associated with adverse effects on human health, including thyroid dysfunction. Young adults, in particular, may be at risk due to their higher exposure to pesticides in the environment. This article explores the exposure assessment of young adults to pesticides that have effects on the thyroid and its implications for "One Health," a concept that emphasizes the interconnectedness of human, animal, and environmental health. HILIC is particularly useful for separating polar metabolites and thyroid hormones before MS analysis. This chromatographic technique enhances the retention and separation of polar compounds, which are often challenging to analyze using traditional reverse-phase liquid chromatography. Mass spectrometry is a powerful analytical technique that has revolutionized the field of metabolomics by enabling the precise identification and quantification of small molecules in complex biological matrices. The study of cerebrospinal fluid is particularly important in neurobiological research because CSF is in direct contact with the brain and spinal cord, providing a window into the biochemical environment of the central nervous system. This article explores recent advancements in the enhanced mass spectrometry identification of polar metabolites and thyroid hormones in rodent cerebrospinal fluid, focusing on the technological improvements and their implications for neurobiological and endocrinological research [1].

Description

"One Health" recognizes that the health of humans, animals, and the environment are interconnected. Pesticide exposure in young adults not only affects their health but also has implications for the health of animals and the environment. Pesticides can contaminate soil, water, and food sources, leading to potential exposure in wildlife and domestic animals. Additionally, pesticide residues can accumulate in the environment, impacting ecosystem health. By understanding the risks associated with pesticide exposure in young adults, we can take a holistic approach to protect human, animal, and environmental health. This includes implementing policies to reduce pesticide use, promoting organic farming practices, and educating the public about the potential health effects of pesticide exposure. Collaborative efforts between health professionals, environmental scientists, policymakers, and the agricultural industry are essential to address the complex issue of pesticide exposure and its impact on One Health [2].

Conclusion

Pesticide exposure in young adults is a significant public health concern, particularly due to its potential effects on thyroid function. Assessing pesticide exposure through biomonitoring, environmental monitoring, and exposure modeling can help identify at-risk populations and develop strategies to minimize exposure. Adopting a "One Health" approach is crucial for addressing the interconnected nature of pesticide exposure and its impact on human, animal, and environmental health. Young adults working in agriculture, landscaping, or pest control may be exposed to pesticides directly during application or indirectly through contaminated clothing or equipment. Living in or near agricultural areas or using pesticides in and around the home can lead to exposure through inhalation, dermal contact, or ingestion of contaminated food or water. Consumption of fruits, vegetables, and grains treated with pesticides can contribute to overall pesticide exposure levels. Use of pesticides for pest control indoors can result in higher. Enhanced mass spectrometry techniques have significantly advanced our ability to identify and quantify polar metabolites and thyroid hormones in rodent cerebrospinal fluid. These advancements provide valuable insights into the biochemical environment of the CNS, aiding in the understanding of neurological and endocrine disorders. As MS technology continues to evolve, it will undoubtedly play an increasingly important role in neurobiological research, offering new opportunities for diagnosis, treatment, and prevention of CNS diseases.

References

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