Nanotechnology Improves Activity of Plants for Medicinal Purposes

Tankiso Sello^*
*Correspondence: Tankiso Sello, Department of Pharmacy, National University of Lesotho, Roma, Lesotho, Email:

Introduction

Since ancient times, people have traditionally used plants for medicinal purposes, either directly or through extraction. Plants have been used for human health due to their low cost, low side effects, and widespread acceptance. They are also a source of a variety of phytochemicals. Traditional medicine relies heavily on phytochemicals, or secondary metabolites, which are substances produced by plants. Optional metabolites have been displayed to show different natural exercises, which give a logical premise to the utilization of spices in customary medication. They have pharmacological effects that can be used to treat infections caused by bacteria and fungi as well as long-term degenerative diseases like diabetes and cancer. Herbal medicines are becoming more and more popular all over the world because they are considered safe and less expensive than modern conventional medicines and have the potential to treat, maintain, and improve health as well as prevent and treat a number of diseases. However, the majority of these phytochemical components with biological activity have limitations; Specifically, their low bioavailability results in decreased biological activity due to their low absorption and distribution as well as their generally low target specificity. These phytochemical compounds also require large doses to produce their activity, and some of them are sensitive to acidic conditions and have low stability. These cutoff points ruin their clinical application [1].

Description

The primary active compound that was isolated from the roots of Pueraria lobata (Willd.) is called puerarin. Ohwi, which has a wide range of pharmacological effects. Diabetes, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer are all treated with puerarin. The solubility of puerarin in water is low: 0.46 mg/mL. Puerarin has a maximum solubility of 7.56 mg/mL in phosphate buffers with a pH of 7.4. The low solvency restricts the use of puerarin. Research into increasing puerarin's bioavailability has expanded rapidly in recent years. The solid lipid nanoparticle (SLN) carrier system is one of a number of nanotechnology options that have been looked into for increasing puerarin's bioavailability. SLN-puerarin is absorbed more quickly than puerarin suspension. This is upheld by a more limited Tmax. Additionally, SLN-puerarin outperformed puerarin suspension in terms of bioavailability [2].

Nanotechnology-based conveyance frameworks capability as medication transporters that can conquer the different limits that natural meds face including expanding the bioavailability and bioactivity of phytochemicals. When applied to phytochemical components, nanotechnology can be a promising new technology that improves the phytotherapy efficacy of herbal medicines. The advancement of a proficient and safe medication conveyance framework is the objective of different scientists. Ongoing improvements in the area of nanotechnology have prompted restored interest in natural restorative plans. Numerous methods for delivering drugs, including phytosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), polymeric nanoparticles, and nano emulsions, have been put forward. Since nanoparticles have been used to change and improve the pharmacokinetic properties of various drugs, the nanotechnology approach is expected to make herbal medicines more bioavailable and bioactive. The purpose of this article review is to provide an overview of the most recent developments in the creation of herbal drug formulations based on nanotechnology that boost herbal activity. A submicrometer, or 0.1 m, is the particle diameter of the nanoscale system. This makes this nanotechnology more developed and widely studied by researchers, and it offers several advantages in relation to various aspects, such as the route of administration and increased therapeutic effects. Many investigations have joined home grown medication with nanotechnology in light of the fact that nano-sized frameworks can increment action, lessen doses, and limit secondary effects.

Home grown prescriptions utilizing nanotechnology-based conveyance frameworks have incredible potential and interesting properties, for example, having the option to change over less dissolvable, inadequately consumed, unsound substances into promising medications. As a result, nanotechnologybased delivery systems have the potential to improve herbal activity and solve the problems that come with herbal medicine. To make phytochemical compounds more bioavailable and bioactive, new technology has been used. The ability to develop drug delivery formulations that are suitable is of the utmost importance for the development of new nanotechnology-based therapies. Effective disease treatment and prevention depend on phytochemical delivery. These delivery systems, which have the potential to boost phytochemical compounds' bioactivity, include polymer-based and lipid-based delivery systems. Vesicular medication conveyance frameworks can be characterized as exceptionally requested gatherings comprising of at least one concentric bilayers shaped because of self-get together within the sight of water. SLN and NLC are two sorts of nanoparticle frameworks comprising of lipid centers shaped from strong lipids or blends with fluid lipids. Nano emulsions are used to make hydrophobic drugs and drugs with a high first-pass metabolism more bioavailable. Water, water-soluble cosolvents, oils, lipids, surfactants, and other components make up the nanoemulsion system [3-5].

Conclusion

In conclusion, phytochemical constituents are delivered using nanotechnology-based delivery systems in public healthcare settings all over the world. Although the use of herbal medicines is on the rise all over the world, their limitations in clinical use as medicines include being physically and chemically unstable, easily degraded, and lacking in solubility, bioavailability, and pharmacological activity. As a result, developing herbal medicines with delivery systems based on nanotechnology could be an alternative approach for increasing their pharmacological activity. However, in order to guarantee their safety and effectiveness in treating a variety of diseases, further research into the development of these nanotechnology-based delivery systems is required, particularly in terms of safety and toxicity profiles.

References

1. Ijaz, Shakeel, Naveed Akhtar, Muhammad Shoaib Khan and Abdul Hameed et al. "Plant derived anticancer agents: A green approach towards skin cancers." Biomed Pharmacother 103 (2018): 1643-1651.

Google Scholar, Crossref, Indexed at

2. Ahmed, Hiwa M. "Ethnopharmacobotanical study on the medicinal plants used by herbalists in Sulaymaniyah Province, Kurdistan, Iraq." J Ethnobiol Ethnomed 12 (2016): 1-17.

Google Scholar, Crossref, Indexed at

3. Kumar, Manish, Ram Singh Bishnoi, Ajay Kumar Shukla and Chandra Prakash Jain. "Techniques for formulation of nanoemulsion drug delivery system: A review." Prev Nutr Food Sci 24 (2019): 225.

Google Scholar, Crossref, Indexed at

4. Németh, Zsófia, Edina Pallagi, Dorina Gabriella Dobó and Gabor Kozma et al. "An updated risk assessment as part of the QbD-based liposome design and development." Pharmaceutics 13 (2021): 1071.

Google Scholar, Crossref, Indexed at

5. Chi, Cheng, Chenshuang Zhang, Yang Liu and Haichen Nie. "Phytosome-nanosuspensions for silybin-phospholipid complex with increased bioavailability and hepatoprotection efficacy." Eur J Pharm Sci 144 (2020): 105212.

Google Scholar, Crossref, Indexed at