Oral Health Polyphenols: Preservation of Homeostasis, Prevention of Illness and Therapeutic Uses

Isabella Conti^*
*Correspondence: Isabella Conti, Department of Dentistry, William Beaumont University Hospital, Royal Oak, MI, USA, Email:

Introduction

Oral health plays a critical role in overall well-being, and emerging research continues to shed light on the many ways in which nutrition and natural compounds can influence oral health. Among these compounds, polyphenols have garnered significant attention for their beneficial effects in preserving oral homeostasis, preventing oral diseases, and offering potential therapeutic applications. Polyphenols are naturally occurring antioxidants found in various plant-based foods such as fruits, vegetables, tea, and red wine. These compounds possess a wide range of biological activities, including anti-inflammatory, antimicrobial, and antioxidant properties, which make them particularly relevant to oral health. The oral cavity is a complex environment, constantly exposed to various internal and external factors that can influence its microbial balance and contribute to disease development. Oral diseases such as dental caries, periodontal disease, and oral cancer are prevalent worldwide and often have a significant impact on individuals' quality of life [1].

Maintaining a healthy oral microbiome and preventing the imbalance that leads to disease is essential for preserving oral health. Polyphenols have been shown to play a vital role in supporting oral homeostasis by modulating the oral microbiome, enhancing the immune response, and preventing oxidative stress. The oral microbiome, composed of diverse bacteria, fungi, and viruses, is a delicate ecosystem that contributes to both oral health and disease. When this microbial balance is disrupted, pathogenic organisms may proliferate, leading to conditions such as gingivitis, periodontitis, and even systemic diseases. Polyphenols can help maintain the balance of the oral microbiota by inhibiting the growth of harmful microorganisms, while promoting the growth of beneficial bacteria. Research has demonstrated that polyphenols from green tea, for example, possess antimicrobial properties that can suppress the growth of Streptococcus mutans, a key bacteria involved in the development of dental caries. Additionally, polyphenols have been shown to enhance the growth of probiotic bacteria, thus promoting a healthy oral microbiome [2].

Description

Oxidative stress is another major factor contributing to oral disease. It is caused by an imbalance between Reactive Oxygen Species (ROS) and the body’s antioxidant defense system. Excessive ROS can lead to inflammation, tissue damage, and the breakdown of oral tissues, resulting in diseases such as periodontal disease and oral cancer. Polyphenols, with their potent antioxidant properties, help neutralize free radicals and reduce oxidative stress in the oral cavity. By scavenging free radicals, polyphenols can protect oral tissues from oxidative damage, preserve gum health, and reduce the risk of oral cancer. The consumption of polyphenol-rich foods such as berries, apples, and tea can thus have a preventive effect on oxidative damage to oral tissues and contribute to overall oral health [3].

In addition to their role in preventing oral diseases, polyphenols have therapeutic applications that are currently being explored. Research has shown that polyphenols can enhance the healing process of oral tissues following injury or surgery. For instance, polyphenols derived from plants like pomegranate have been shown to promote tissue regeneration and reduce inflammation in periodontal disease, making them promising candidates for the development of therapeutic agents in oral healthcare. Polyphenols can also aid in the management of oral infections, such as those caused by Candida albicans, which can lead to conditions like oral thrush. Studies have demonstrated that polyphenol-rich extracts, such as those from cranberry and grape seed, can inhibit the growth of Candida and reduce the risk of fungal infections in the oral cavity [4].

The therapeutic uses of polyphenols are not limited to their antiinflammatory and antimicrobial properties. Recent studies have suggested that polyphenols may also play a role in the prevention and management of conditions like dry mouth, a common issue that can result from aging, medication side effects, or certain diseases. Dry mouth, or xerostomia, can lead to difficulties in speaking, swallowing, and maintaining oral hygiene, and it significantly impacts the quality of life. Polyphenols may help alleviate dry mouth symptoms by stimulating salivation and improving the function of salivary glands. In addition, the antibacterial properties of polyphenols can help prevent secondary infections that may occur in a dry mouth environment [5].

Conclusion

As we continue to uncover the potential of polyphenols in oral health, it is important to recognize their multifaceted nature. These compounds not only support the prevention of oral diseases but also offer a wide range of therapeutic uses that can enhance the management of existing conditions. However, the bioavailability of polyphenols, or the degree to which they are absorbed and utilized by the body, can vary depending on the source and processing of the polyphenol. Further research is needed to better understand how to optimize the delivery of polyphenols to the oral cavity and enhance their therapeutic effects. Additionally, while polyphenols can be a valuable component of a healthy diet, they should not be seen as a substitute for good oral hygiene practices, such as regular brushing and flossing, as well as routine visits to the dentist.

In conclusion, polyphenols represent a promising and natural avenue for the preservation of oral health, the prevention of oral diseases, and the development of novel therapeutic interventions. Through their ability to modulate the oral microbiome, combat oxidative stress, and provide antimicrobial and anti-inflammatory effects, polyphenols offer a multifaceted approach to oral health. The growing body of evidence supporting their benefits highlights their potential in the prevention and management of common oral conditions, such as dental caries, periodontal disease, and oral cancer. As research continues to explore the diverse applications of polyphenols, they may become an integral part of oral healthcare strategies, promoting better oral health and overall well-being.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Trisha, Anuva Talukder, Mynul Hasan Shakil, Suvro Talukdar and Wahidu Zzaman. "Tea polyphenols and their preventive measures against cancer: Current trends and directions." Food 11 (2022): 3349.

Google Scholar, Crossref, Indexed at

2. Singla, Rajeev K., Ashok K. Dubey, Arun Garg and Ramesh K. Sharma, et al. "Natural polyphenols: Chemical classification, definition of classes, subcategories, and structures." J AOAC Int 102 (2019): 1397-1400.

Google Scholar, Crossref, Indexed at

3. Tangney, Christy C. and Heather E. Rasmussen. "Polyphenols, inflammation, and cardiovascular disease." Curr Atheroscler Rep 15 (2013): 1-10.

Google Scholar, Crossref, Indexed at

4. Yamashita, Yoshihisa and Toru Takeshita. "The oral microbiome and human health." J Oral Sci 59 (2017): 201-206.

Google Scholar, Crossref, Indexed at

5. Koo, Hyun, Raymond N. Allan, Robert P. Howlin and Paul Stoodley, et al. "Targeting microbial biofilms: Current and prospective therapeutic strategies." Nat Rev Microbiol 15 (2017): 740-755.

Google Scholar, Crossref, Indexed at