Orientational Cell Adhesions in Tissue Morphogenesis

Simone Maurea^*
*Correspondence: Simone Maurea, Department of Pathology, Ege Univer University of Medicine and Pharmacy sity, 050474 Bucharest, Romania, Email:

Introduction

Cell adhesion refers to the binding of cells to other cells or extracellular matrix components. It is a fundamental process that is critical for many biological functions, such as tissue development, wound healing, and immune response. Adhesion occurs through the interactions of specific adhesion molecules that are located on the surface of cells. These molecules can be classified into two main types: cell-cell adhesion molecules and cell-matrix adhesion molecules. Cellcell adhesion molecules are responsible for the binding of cells to each other. There are several types of cell-cell adhesion molecules, including cadherins, immunoglobulin superfamily proteins, selectins, and integrins. Cadherins are calcium-dependent adhesion molecules that play a crucial role in maintaining tissue integrity by mediating cell-cell adhesion. There are several types of cadherins, including E-cadherin, N-cadherin, and P-cadherin. E-cadherin is predominantly found in epithelial cells, while N-cadherin is found in neurons and P-cadherin is found in placenta cells.

Description

IgSF proteins are another group of cell-cell adhesion molecules that are characterized by their immunoglobulin-like domains. These molecules are involved in a wide range of cellular processes, including immune response, neural development, and synapse formation [1]. Examples of IgSF proteins include neural cell adhesion molecule (NCAM), L1 cell adhesion molecule, and intercellular adhesion molecule-1.Selectins are a family of cell-surface proteins that mediate the interaction between leukocytes and endothelial cells during the process of inflammation. There are three types of selectins: L-selectin, P-selectin, and E-selectin. L-selectin is expressed on leukocytes and binds to high endothelial venules (HEVs) in lymphoid tissue. P-selectin is expressed on activated platelets and endothelial cells, while E-selectin is expressed on endothelial cells in response to inflammatory cytokines [2].

Integrins are a family of transmembrane receptors that mediate cell-matrix adhesion. These molecules consist of two subunits, alpha and beta, that together form a heterodimeric structure. Integrins bind to extracellular matrix proteins, such as fibronectin and laminin, as well as to cell-surface molecules, such as ICAM-1 and VCAM-1. Integrins are involved in many cellular processes, including cell migration, differentiation, and proliferation. Cell-matrix adhesion molecules are responsible for the binding of cells to the extracellular matrix. There are several types of cell-matrix adhesion molecules, including integrins, syndecans, and proteoglycans. Integrins have already been discussed, but syndecans and proteoglycans are two other important classes of cell-matrix adhesion molecules [3].

Syndecans are transmembrane proteoglycans that are found on the surface of many different cell types. These molecules have a core protein that is attached to glycosaminoglycan (GAG) chains, which are long chains of repeating disaccharide units. Syndecans bind to extracellular matrix proteins, such as fibronectin and collagen, as well as to growth factors and cytokines. They are involved in many cellular processes, including cell adhesion, migration, and signaling. Proteoglycans are a family of glycoproteins that consist of a protein core and one or more GAG chains.

Cell surface receptors play a critical role in mediating cell adhesion. These receptors are transmembrane proteins that bind to other cells or to the ECM. The most well-known cell surface receptors involved in cell adhesion are the integrins. Integrins are a family of heterodimeric receptors that are composed of an alpha and beta subunit. Integrins bind to a variety of ECM proteins, including fibronectin, laminin, and collagen, as well as to other cell surface receptors. The binding of integrins to ECM proteins is essential for the attachment of cells to the ECM and for the regulation of cell behavior [4,5].

Cell adhesion is essential for a variety of biological processes, including tissue development and maintenance, immune responses, and wound healing. During tissue development, cell adhesion plays a critical role in the formation of tissues and organs. Cells must adhere to one another and to the ECM in order to form tissues and organs with the appropriate structure and function. During immune responses, cell adhesion is involved in the recruitment of immune cells to sites of infection or injury. Immune cells must adhere to the endothelium and migrate across the blood vessel wall in order to reach the site of infection or injury. During wound healing, cell adhesion is involved in the formation of a new extracellular matrix and the migration of cells to the site of injury.

Conclusion

Adhesion molecules are another important class of molecules involved in cell adhesion. Adhesion molecules are transmembrane proteins that are involved in the binding of cells to one another. There are several different families of adhesion molecules, including cadherins, selectins, and immunoglobulin superfamily (IgSF) members. Cadherins are calcium-dependent adhesion molecules that mediate homophilic interactions between cells. Cadherins are involved in a variety of biological processes, including tissue development and maintenance, cell migration, and signaling. Selectins are carbohydrate-binding proteins that mediate the interaction between cells and the endothelium during inflammation. IgSF members are a diverse group of proteins that are involved in a variety of biological processes, including cell adhesion, immune function, and signaling.

References

1. Karan Križanac, Dragana, Antonela Krasić Arapović, Siniša Skočibušić and Irena Pintarić, et al. "CD44 Immunoexpression is unfavorable predictor in ovarian serous cancer." Appl Immunohistochem Mol Morphol 26 (2018): 398-402.

Google Scholar, Crossref, Indexed at

2. Sofias, Alexandros Marios, Michael Dunne, Gert Storm and Christine Allen, et al. "The battle of “nano” paclitaxel." Adv Drug Deliv Rev 122 (2017): 20-30.

Google Scholar, Crossref, Indexed at

3. Fujiwara, Keiichi, Kosei Hasegawa and Shoji Nagao. "Landscape of systemic therapy for ovarian cancer in 2019: Primary therapy." Cancer 125 (2019): 4582-4586.

Google Scholar, Crossref, Indexed at

4. Lisio, Michael-Antony, Lili Fu, Alicia Goyeneche and Zu-hua Gao, et al. "High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints." Int J Mol Sci 20 (2019): 952.

Google Scholar, Crossref, Indexed at

5. Siegel, Rebecca L., Kimberly D. Miller and Ahmedin Jemal. "Cancer statistics." Cancer Surgery (2018).

Google Scholar, Crossref, Indexed at