Patients with Unknown Nephropathy: What's Hidden? The Key to the Diagnosis and Treatment of Kidney Transplantation May Be Genetic Screening

Adele Bari^*
*Correspondence: Adele Bari, Department of Surgery, Paediatrics, Obstetrics and Gynaecology, University of Murcia, 30100 Murcia, Spain, Email:

Keywords

Vaccine • Pneumococcal disease • Demographic changes

Introduction

Unknown nephropathy refers to cases of CKD where the underlying cause is unclear despite thorough investigation. This presents a challenge for clinicians, as accurate diagnosis is crucial for guiding treatment decisions, including the suitability for kidney transplantation. Common causes of unknown nephropathy include diabetic nephropathy, hypertensive nephropathy, and glomerulonephritis, among others. However, in some cases, the underlying cause remains elusive, highlighting the need for novel diagnostic approaches. Genetic screening has emerged as a valuable tool for identifying genetic mutations that contribute to kidney disease. Advances in next-generation sequencing (NGS) technologies have made it possible to sequence the entire human genome rapidly and cost-effectively, allowing for comprehensive genetic analysis in patients with unknown nephropathy. Genetic screening can help identify genetic variants associated with kidney disease, providing insights into the underlying pathogenesis and guiding treatment decisions [1,2].

Literature Review

Genetic screening has significant implications for kidney transplantation, particularly in cases of unknown nephropathy. Genetic variants associated with kidney disease can influence the risk of transplant rejection, response to immunosuppressive therapy, and long-term graft survival. By identifying these genetic variants, clinicians can tailor immunosuppressive regimens and post-transplant monitoring strategies to optimize outcomes for kidney transplant recipients with unknown nephropathy [3,4].

Discussion

While genetic screening holds promise for improving the diagnosis and treatment of kidney disease, there are challenges and considerations that must be addressed. These include the interpretation of genetic variants, the need for genetic counseling, and ethical considerations related to genetic testing. Additionally, the cost and accessibility of genetic screening may limit its widespread adoption, particularly in resource-limited settings [5,6].

Conclusion

The future of genetic screening in kidney transplantation lies in the development of personalized medicine approaches that integrate genetic information into clinical decision-making. This includes the use of genetic profiling to identify patients at high risk of transplant rejection and the development of targeted therapies based on individual genetic profiles. By embracing these advances, we can improve outcomes for kidney transplant recipients with unknown nephropathy and pave the way for more personalized and effective treatments for CKD. Genetic screening has the potential to revolutionize the diagnosis and treatment of kidney disease, particularly in cases of unknown nephropathy. By identifying genetic variants associated with kidney disease, clinicians can tailor treatment strategies to optimize outcomes for kidney transplant recipients. While challenges remain, the promise of genetic screening in kidney transplantation is undeniable, offering new hope for patients with CKD and paving the way for more personalized and effective treatments in the future.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Hill, Nathan R., Samuel T. Fatoba, Jason L. Oke and Jennifer A. Hirst, et al. "Global prevalence of chronic kidney disease–a systematic review and meta-analysis." PloS one 11 (2016): 0158765.

Google Scholar, Crossref, Indexed at

2. Quaglia, Marco, Claudio Musetti, Gian Marco Ghiggeri and Giovanni Battista Fogazzi, et al. "Unexpectedly high prevalence of rare genetic disorders in kidney transplant recipients with an unknown causal nephropathy." Clin Transplant 28 (2014): 995-1003.

Google Scholar, Crossref, Indexed at

3. Limou, Sophie, Nicolas Vince and Afshin Parsa. "Lessons from CKD-related genetic association studies–moving forward." Clin J Am Soc Nephro 13 (2018): 140-152.

Google Scholar, Crossref, Indexed at

4. Kramer, Anneke, Maria Pippias, Marlies Noordzij and Vianda S. Stel, et al. "The european renal association–european dialysis and transplant association (ERA-EDTA) registry annual report 2015: A summary." Clin Kidney J 11 (2018): 108-122.

Google Scholar, Crossref, Indexed at

5. Bassanese, Giulia, Tanja Wlodkowski, Aude Servais and Laurence Heidet, et al. "The European rare kidney disease registry (ERKReg): Objectives, design and initial results." Orphanet J Rare Dis 16 (2021): 251.

Google Scholar, Crossref, Indexed at

6. Devuyst, Olivier, Nine VAM Knoers, Giuseppe Remuzzi and Franz Schaefer. "Rare inherited kidney diseases: Challenges, opportunities and perspectives." The Lancet 383 (2014): 1844-1859.

Google Scholar, Crossref, Indexed at