Preventing and Managing Coronary Artery Disease

Jamillo Liana^*
*Correspondence: Jamillo Liana, Department of Biomedical Science, CHA University, Seongnam, Korea, Email:

Introduction

Coronary Artery Disease (CAD) is a prevalent and potentially life-threatening cardiovascular condition that affects millions of people worldwide. It is a leading cause of heart attacks and other heart-related complications. This comprehensive 2500-word article aims to provide a thorough understanding of CAD, including its causes, symptoms, diagnosis, treatment options, and strategies for prevention. Coronary artery disease, often referred to as coronary heart disease or simply heart disease, is a cardiovascular disorder characterized by the narrowing or blockage of the coronary arteries, which supply blood and oxygen to the heart muscle. This condition can lead to a range of heart-related problems, with the most severe being a heart attack [1].

Description

The primary cause of CAD is atherosclerosis, a condition in which fatty deposits (plaques) build up on the inner walls of the coronary arteries, causing them to narrow and restrict blood flow to the heart. Several risk factors increase the likelihood of developing CAD, including smoking, high blood pressure, high cholesterol levels, diabetes, obesity and a family history of heart disease. Unhealthy lifestyle choices such as a sedentary lifestyle, poor diet, excessive alcohol consumption and chronic stress can contribute to the development and progression of CAD [2].

CAD often presents with various symptoms, and their severity can vary from person to person. Common symptoms include Angina is the hallmark symptom of CAD, typically characterized by chest pain or discomfort that may radiate to the arm, shoulder, jaw, or back. Stable angina occurs predictably with physical exertion or stress, while unstable angina can happen at rest and is more severe, indicating an increased risk of a heart attack. Some individuals with CAD may experience "silent ischemia," where they have reduced blood flow to the heart muscle without noticeable symptoms. A heart attack (myocardial infarction) occurs when a coronary artery becomes completely blocked, leading to the death of heart muscle tissue. These can include severe chest pain or discomfort, shortness of breath, nausea, lightheadedness and cold sweats. A comprehensive medical history and physical examination help assess risk factors and identify symptoms. ECG records the heart's electrical activity and can detect abnormal rhythms or signs of a heart attack. Stress tests, like the treadmill test, assess the heart's response to physical exertion and can uncover hidden CAD. Cardiac imaging tests, such as coronary angiography, CT angiography or MRI, provide detailed images of the coronary arteries to identify blockages. Blood tests can measure cardiac biomarkers like troponin to detect heart muscle damage indicative of a heart attack [3,4].

Lifestyle changes, including a heart-healthy diet, regular exercise, smoking cessation and stress management, are essential for managing CAD. Medications can help control risk factors like high blood pressure, cholesterol levels and diabetes. Antiplatelet drugs and anticoagulants reduce the risk of blood clots and heart attacks. Nitroglycerin and beta-blockers can relieve angina symptoms. Percutaneous Coronary Intervention (PCI) involves using a balloon catheter to open narrowed arteries and placing a stent to keep them open. Coronary Artery Bypass Grafting (CABG) surgery reroutes blood flow around blocked coronary arteries by using grafts from other blood vessels. Preventing CAD is essential for reducing the burden of heart disease on individuals and society as a whole. Prevention strategies include: Adopting a heart-healthy diet rich in fruits, vegetables, whole grains and lean proteins. Engaging in regular physical activity to maintain a healthy weight and improve cardiovascular fitness. Quitting smoking and reducing alcohol consumption. Managing stress through relaxation techniques, meditation or counselling [5].

Conclusion

Coronary artery disease is a prevalent and potentially life-threatening condition that affects the coronary arteries, leading to reduced blood flow to the heart muscle. It is essential to understand the causes, symptoms, diagnosis, treatment options, and prevention strategies to effectively manage CAD and reduce the risk of heart-related complications. Taking prescribed medications as directed to control risk factors and prevent complications. Routine medical checkups to assess heart health and detect risk factors early. By making informed lifestyle choices and adhering to medical advice, individuals can take proactive steps to protect their heart health and lead longer, healthier lives.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Huang, Jingyan, Siyun Huang, Jinhong Li and Minhua Li, et al. "CALM1 rs3179089 polymorphism might contribute to coronary artery disease susceptibility in Chinese male: A case–control study." Genes Genom (2022): 1-9.

Google Scholar, Crossref, Indexed at

2. Libby, Peter and Pierre Theroux. "Pathophysiology of coronary artery disease." Circ 111 (2005): 3481-3488.

Google Scholar, Crossref, Indexed at

3. Biselli, Patrícia Matos, Alexandre Rodrigues Guerzoni, Moacir Fernandes de Godoy and Marcos Nogueira Eberlin, et al. "Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease." J Thromb Thrombolysis 29 (2010): 32-40.

Google Scholar, Crossref, Indexed at

4. Brevik, Asgeir, Stein Emil Vollset, Grethe S. Tell and Helga Refsum, et al. "Plasma concentration of folate as a biomarker for the intake of fruit and vegetables: The hordaland homocysteine study." Am J Clin Nutr 81 (2005): 434-439.

Google Scholar, Crossref, Indexed at

5. Yuan, Mei, Qiong Zhan, Xiaomei Duan and Bingxin Song, et al. "A functional polymorphism at miR-491-5p binding site in the 3′-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population." Atherosclerosis 226 (2013): 447-452.

Google Scholar, Crossref, Indexed at