Recent Advances in Silver Nanoparticle-Based Advanced Translational Applications

Sarna Kawabori^*
*Correspondence: Sarna Kawabori, Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa, Email:

Introduction

Silver Nanoparticles (AgNPs) have long captured the attention of researchers due to their unique physical, chemical and biological properties. As nanotechnology continues to evolve, silver nanoparticles are increasingly finding their way into a variety of advanced translational applications. Recent advancements in this field have expanded their utility far beyond traditional uses, unlocking new potential in medicine, diagnostics and environmental science. Silver nanoparticles have demonstrated remarkable antimicrobial properties, making them valuable in treating infections. Recent developments have enhanced their efficacy by optimizing their size, shape and surface chemistry. Researchers are exploring AgNPs as alternatives to conventional antibiotics, particularly in combating antibiotic-resistant strains. Advanced formulations, such as AgNPs embedded in dressings or coatings, are showing promise in wound healing and infection control [1].

The use of silver nanoparticles in cancer therapy is an exciting area of research. AgNPs can be engineered to target specific cancer cells, reducing damage to healthy tissues. Recent studies have focused on combining AgNPs with chemotherapy or radiotherapy to enhance treatment efficacy. Additionally, researchers are investigating targeted drug delivery systems where AgNPs are conjugated with therapeutic agents, ensuring precise delivery and reducing side effects. Silver nanoparticles have been leveraged for imaging and diagnostic applications due to their strong optical properties. Recent advances have improved their use in imaging techniques like Surface- Enhanced Raman Spectroscopy (SERS) and photoacoustic imaging. AgNPs’ ability to amplify signals makes them excellent candidates for enhancing the sensitivity and resolution of imaging modalities, aiding in early disease detection and diagnosis [2].

Description

AgNPs are increasingly utilized in the development of biosensors due to their high surface area-to-volume ratio and ease of functionalization. Recent innovations have led to highly sensitive and specific biosensors for detecting various biological and chemical analytes. These include glucose sensors for diabetes management and biosensors for detecting pathogens or biomarkers associated with diseases like cancer. In laboratory diagnostics, AgNPs are employed in assays and tests to improve sensitivity and specificity. Recent advances have integrated AgNPs into lateral flow assays and immunoassays, providing rapid and accurate results. These advancements are transforming diagnostic processes by offering more efficient and cost-effective solutions for disease detection and monitoring. The unique properties of AgNPs make them effective in water purification processes. Recent research has enhanced their application in removing contaminants such as bacteria, viruses and heavy metals from water. AgNPs can be used in filters or as part of photocatalytic systems to degrade organic pollutants, contributing to more efficient and sustainable water treatment solutions [3].

Silver nanoparticles are also being explored for their potential in environmental remediation. They are effective in breaking down pollutants and neutralizing toxins in soil and water. Advances in this field have focused on improving the stability and reusability of AgNPs, making them viable for large-scale environmental cleanup projects. Despite the promising advances, several challenges remain in the field of silver nanoparticle applications. These include concerns about toxicity, environmental impact and the need for standardized methods for synthesis and characterization. Future research will need to address these issues while continuing to explore novel applications and optimize existing ones. Recent advances in silver nanoparticle-based technologies underscore their transformative potential across various fields. From medical treatments and diagnostics to environmental applications, AgNPs are proving to be versatile tools with the ability to drive significant improvements in technology and health. As research progresses, it will be crucial to address the associated challenges to fully realize the benefits of silver nanoparticles in advanced translational applications [4].

As silver nanoparticles advance into broader applications, regulatory and safety considerations become increasingly critical. The unique properties of AgNPs necessitate a thorough understanding of their potential risks and benefits to ensure safe use in consumer products and medical devices. Recent efforts have focused on developing comprehensive safety assessments for AgNPs. Studies are examining their potential toxicity, biodistribution and long-term effects on human health and the environment. For instance, researchers are investigating how AgNPs interact with biological systems at the cellular and molecular levels to determine any possible adverse effects. These assessments are crucial for informing guidelines and ensuring the safe incorporation of AgNPs into products.

The regulatory landscape for nanomaterials, including AgNPs, is evolving as their applications expand. Regulatory bodies such as the U.S. Environmental Protection Agency (EPA) and the European Chemicals Agency (ECHA) are working to establish guidelines and standards for the use and disposal of nanomaterials. These frameworks aim to balance innovation with safety, ensuring that the benefits of AgNPs are realized while minimizing risks. Surface modification techniques have been refined to enhance the functionality of AgNPs. Functionalization with various ligands or coatings allows for better targeting in medical applications and improved interactions with specific analytes in biosensing. Recent advances include the development of multifunctional coatings that provide multiple capabilities, such as targeted drug delivery combined with imaging. The continued advancement of silver nanoparticle technologies relies heavily on interdisciplinary collaborations. Combining expertise from materials science, chemistry, biology and engineering facilitates the development of innovative applications and solutions [5].

Conclusion

The field of silver nanoparticles is witnessing rapid advancements that are expanding their utility across diverse domains. From revolutionizing medical treatments and diagnostics to addressing environmental challenges, AgNPs offer remarkable potential. However, continued research, regulatory oversight and interdisciplinary collaboration are essential to address safety concerns and optimize their applications. As innovations continue to unfold, silver nanoparticles are poised to play a transformative role in the development of advanced technologies and solutions for a range of global challenges.

Acknowledgement

None.

Conflict of Interest

There are no conflicts of interest by author.

References

1. Husain, Shaheen, Sumbul Afreen, Durdana Yasin and Bushra Afzal, et al. "Cyanobacteria as a bioreactor for synthesis of silver nanoparticles-an effect of different reaction conditions on the size of nanoparticles and their dye decolorization ability."J Microbiol Methods 162 (2019): 77-82.

   Google Scholar, Crossref, Indexed at

2. Husain, Shaheen, Suresh K. Verma, Durdana Yasin and M. Moshahid, et al. "Facile green bio-fabricated silver nanoparticles from microchaete infer dose-dependent antioxidant and anti-proliferative activity to mediate cellular apoptosis." Bioinorg Chem 107 (2021): 104535.

   Google Scholar, Crossref, Indexed at

3. de Castro, Denise Tornavoi, Cássio do Nascimento, Oswaldo Luiz Alves and Emerson de Souza Santos,et al. "Analysis of the oral microbiome on the surface of modified dental polymers."Arch Oral Biol 93 (2018): 107-114.

   Google Scholar, Cross Ref , Indexed at

4. Mahross, Hamada Zaki and Kusai Baroudi. "Effect of silver nanoparticles incorporation on viscoelastic properties of acrylic resin denture base material."Eur J Dent 9 (2015): 207-212.

   Google Scholar, Crossref, Indexed at

5. Ferraris, Sara Andrea Cochis, Martina Cazzola and Mauro Tortello, et al. "Cytocompatible and anti-bacterial adhesion nanotextured titanium oxide layer on titanium surfaces for dental and orthopedic implants." Front Bioeng Biotechnol7 (2019): 103.

   Google Scholar, Crossref, Indexed at