Short Communication - (2021) Volume 5, Issue 1
Multiple sclerosis (MS) is taken into account AN inflammatory reaction neurological unwellness that's characterised by pathologic changes, as well as degenerative disorder and nerve fiber injury. the primary man pictures of MS were created within the early Eighties, once man was introduced into hospitals. The high conspicuity abnormal signal intensities of MS lesions seen on man imaging provided the simplest read nevertheless of tissue injury, lesion activity, and unwellness accumulation compared with all alternative imaging modalities, as well as CT. Since then, man imaging has become a routine clinical examination in MS and is employed to assist the designation and track the natural course of the unwellness. With the appearance of newer quantitative man techniques—including volumetrical man imaging, magnetization transfer imaging (MTI), diffusion tensor imaging (DTI), and nucleon man (1H-MR) spectroscopy—our ability to observe and characterize the unwellness burden, as well as occult microscopic unwellness invisible once exploitation standard man techniques, has for the most part improved. Today, man imaging is that the most significant paraclinical tool for MS, and man imaging–derived measures are established as normal outcome markers to observe the treatment response in numerous MS clinical trials. Magnetic resonance imaging has been crucial within the development of medication disease-modifying treatments. this landscape of degenerative disorder clinical trials is presently increasing to incorporate testing not solely of medication agents, however conjointly neuroprotective, remyelinating, neuromodulating, and restorative therapies. this is often very true of therapies targeting progressive types of the unwellness wherever neurodegeneration may be a distinguished feature. Imaging techniques of the brain and medulla spinalis have speedily evolved within the last decade to allow in vivo characterization of tissue microstructural changes, property, metabolic changes, neuronic loss, interstitial tissue activity, and degenerative disorder. Advanced resonance imaging techniques hold vital promise for fast the event of various treatment modalities targeting a spread of pathways in MS. Conventional man Imaging Conventional man scanning offers the foremost sensitive thanks to observe MS lesions and their changes and plays a dominant role in ruling in or ruling out a designation of MS. though MS lesion plaques may be found throughout the brain, they need a predilection for periventricular nervous tissue and have a tendency to own AN ovoid configuration with the foremost axes perpendicular to the bodily cavity surface. Advances in observance MS progression Conventional brain imaging is progressively wont to support clinicians in observance the progression of MS.6 In early MS, the imaging image is characterised by the event of recent WM lesions, as markers of inflammation and active degenerative disorder. a better variety of WM lesions at unwellness onset and also the increase in lesion volume over the primary the primary CIS will increase the chance of clinically definite MS and worse incapacity in studies on massive multicenter cohorts with long follow up. In distinction, in progressive MS, new active lesions area unit rare, however pre-existing T2 lesions might show slowly increasing lesions (SELs), reflective tissue loss within the absence of current acute inflammation, unconcealed by the presence of a rim of iron-containing cells at the lesion border, thought to represent activated microglia/macrophages. This iron rim at the sting of MS lesions is preponderantly seen in SELs, less ofttimes in inactive lesions, not seen in active and hardly in remyelinated lesions. Recently, Elliot and colleagues developed a way for the automated detection of SELs on standard brain tomography and advised SELs as a possible imaging biomarker for chronic inflammation in MS.
Since last year, due to the new infectious disease in the world, various interventions have been required in the world [1]. We have to resist against COVID-19 while living well together [2]. The tips for these problems are roughly divided into two aspects, which are for infection and for lifestyle. In this article, the author would like to explain the latter in 3 categories with 10 items, and then enlighten Hinohara-ism by Shigeaki Hinohara, a supreme physician who continued extraordinary activity until the age of 105 [3]. The first is a basic lifestyle. To prevent infectious diseases, it is important to maintain one's immunity by appropriate lifestyle. 1. Meal and exercise habits: Keep regular rhythm of three meals at the same time every day. As for the dietary content, the low-carbohydrate diet (LCD) is recommended with decreasing sweets late at night [4]. Continue exercise about 20-30 minutes once a day with heart rate around 110-120/min [5]. 2. Sound sleep: Sleeping time should be about 7 hours. Keep the wake-up time constant rather than going to bed. Quiet music for music therapy or aromatherapy can be helpful [6]. 3. Natural healing power: Do not take medicine immediately when you feel sick. Always improve and stimulate the immunity and natural healing power. Some procedure of integrative medicine (IM) can be applied [7]. 4. Mind and body: Mental and psychological states always influence on one’s health greatly. Always control the mind well objectively, think about the shiny side of things, and try to live a cheerful life. The second is a concrete lifestyle. In order to maintain and improve the health, it is important to take concrete actions every day. 5. Manage stress: In daily life, various stresses always come down. There is a wide variety of stressors such as physics, chemistry, physical, psychological, social, human relationships, the changes from conventional situations, and so on [8]. We have to respond adequately to each stress. Dr. Hinohara has been known worldwide for his humanity and divine Christianity. He worked as not only a physician, but also a philosopher and a musician. He wrote down more than 6000 published articles and more than 400 books [13]. He was physician, Oslerian scholar, peace advocate, prolific author and devout Christian [14]. He has published a newsletter "Educational Medicine" for many years, in which he advocated the name of the lifestyle-related disease for the first time in 1978 [15]. For years, he developed Japanese medicine and taught many medical staffs. In 2000, he established the New Elderly Association (NEA) for the next-coming 21th century (2001-2100) to educate and disseminate his philosophy, Hinohara-ism. NEA has set the doctrine for the theme, mission and goals as follows [16]: i) Theme; to love, to initiate, and to endure, ii) Mission; to transmit the importance of peace and love to children, iii) Goals; to acquire a favorable lifestyle, to provide loving care for other and feel gratitude to daily life, to be aware that it is never too late to initiate or create something, regardless of age, and so on. NEA has been an international association and has many branches. The author has founded the Tokushima branch for development of Hinohara-ism. Various activities include lectures of medicine and anti-aging medicine, seminars of LCD, music therapy, art therapy, concerts, and publication of newsletters. Among them, the book published with Mr. Hinohara is shown in Figure 1. The title is "Let's start with NEA aiming for the significant life”. Concerning the important future direction, 3 C’s were proposed as for challenge to myself, contact to others, and communicate to society.
The authors declare no conflict of interest.
There was no funding received for this paper.
Clinical and Medical Case Reports received 53 citations as per Google Scholar report
