Streptococcus suis as a Model for the Development of Novel Phage-Based Biocontrol Agents: From Farm to Fork

Bogumil Skotarczak^*
*Correspondence: Bogumil Skotarczak, Department of Genetics, Szczecin University, Szczecin, Poland, Email:

Keywords

Phage • Prophages • Food • Zoonosis • Streptococcus suis • Against viral protection

Introduction

The worldwide domesticated animals industry is a significant supporter of food security and financial turn of events, with a worth of around 1.4 trillion bucks]. The Food and Agribusiness Association (FAO) assesses that the domesticated animals area represents 40% of the by and large agrarian result, with around 1.3 billion individuals relying upon the area for vocation and food security. Notwithstanding, irresistible illnesses compromise the maintainability and development of the business. Infections like porcine conceptive and respiratory disorder infection (PRRSV) of pig, cow-like herpesvirus 1 of steers, and irresistible bronchitis infection (IBV) of poultry cause extreme infectious sicknesses inside the domesticated animals industry. Regardless, microorganisms are the key aetiological specialists ensnared in creature microbial sicknesses. Bacterial contaminations, for example, those emerging from Campylobacter spp., Salmonella spp., E. coli, Clostridium spp., Listeria monocytogenes and Streptococcus suis negatively affect creature government assistance and apply colossal monetary misfortunes on the business. It has been assessed that somewhere in the range of 2000 and 2010, zoonotic diseases caused about $20 billion and $200 billion in immediate and aberrant misfortunes, separately [1,2]. In Australia, it was accounted for that business misfortunes and removal of impacted pigs had a related expense of AUD$ 10-30 million. These misfortunes represented a 16-37% decrease in the gross pay in the impacted locales.

Methods

In the twentieth 100 years, the idea of "One Medication" turned into a well known point in general wellbeing. This idea perceived the comparable worldview among veterinary and human medication, especially in their common life systems, physiology and near pathologies. This thought has been extended further to remember the climate for another idea known as "One Wellbeing". One Wellbeing is a cooperative methodology that spotlights on the plan and execution of strategies, programs and legitimate structures pointed toward accomplishing better wellbeing results. Areas of importance incorporate natural debasement, sanitation and security, zoonoses and antimicrobial obstruction. In this manner the anticipation and control of bacterial contaminations is fundamental for not just the manageability and development of the business yet the general strength of the environment. On the ranch, the board rehearses in nurseries and the presentation of transporter younglings impact the spread of contamination among groups. Such administration rehearses are practically all inclusive among animals ranches, which makes the control of disease troublesome. The total destruction of contaminations is impossible, yet educated methodologies have been proposed for disease the board on ranches. Hearty biosecurity, remedial and antibody mediation, as well as cleanliness are among the actions used to forestall or control diseases on ranches [3-5].

Discussion

Campylobacter is a zoonotic microorganism liable for ~25% of all human diarrheal diseases worldwide. The bacterium is predominant in a few food creatures, especially in the avian stomach, and could debase cadavers during postharvest handling. Richards et al. shown the way that a two-phage mixed drink could specifically taint and diminish C. jejuni populaces in the stomach of oven chickens by 2.4 log CFU/g without upsetting the occupant stomach microbiome. One significant obstacle in the phage application in C. jejuni disease is the revealed in vitro and in vivo development of phage-safe secludes (up to 13% of separates). Notwithstanding, levelheaded determination of phages with assorted hereditary attributes can be utilized to decrease the test. By and large, in light of genome size, morphology, and the host receptor utilized during disease, Campylobacter phages were gathered into I, II and III. In a 31- day preliminary, managing one gathering III phage followed by a gathering II phage essentially diminished C. jejuni includes in grill chickens by 3.0 log units contrasted with a two-phage mixed drink made of just gathering III phages (1.0 log unit). Notwithstanding the higher decrease, consolidating bunch II and III brought about lower levels of phage-safe disengages contrasted with utilizing a solitary phage or a homogenous phage mixed drink. The adequacy of this multi-bunch Campylobacter phage mixed drink configuration has been approved in vitro utilizing a few gathering II and III phages. The use of phage treatment in C. jejuni contamination in chickens has been accounted for by different examinations with shifting levels of viability [6].

Conclusion

The rise of anti-microbial safe zoonotic microscopic organisms represents a danger that rises above the food business, influencing the general wellbeing of the climate and other creature populaces. The adequacy and wellbeing of phages have been shown in a few bacterial contaminations, for certain business items previously endorsed in a few nations for use in food creation. Notwithstanding, there are other zoonotic microscopic organisms, including S. suis, for which phage applications remain underexplored. We give experiences on the S. suis phage scene and furthermore portray the counter phage armory of S. suis. Our discoveries uncover the variety and wealth of S. suis prophages, which can be utilized as building blocks for combining safe lytic phages for application in food and medication.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Chan, Benjamin K., Paul E. Turner, Samuel Kim and Hamid R. Mojibian, et al. "Phage treatment of an aortic graft infected with Pseudomonas aeruginosa." Evol Med Public Health (2018), pp: 60-66.

Google Scholar, Crossref

2. Gyles, Carlton. "One medicine, one health, one world." Can Vet J 57 (2016): 345.

Google Scholar, Indexed at

3. Zinsstag, Jakob, Esther Schelling, David Waltner-Toews and Marcel Tanner. "From “one medicine” to “one health” and systemic approaches to health and well-being." Prev Vet Med 101 (2011): 148-156.

 Google Scholar, Crossref, Indexed at

4. Schiffman, Joshua D. and Matthew Breen. "Comparative oncology: What dogs and other species can teach us about humans with cancer." Philos Trans R Soc 370(2015): 20140231.

Google Scholar, Crossref

5. Baums, Christoph Georg, Christoph Kock, Andreas Beineke and Katharina Bennecke, et al. "Streptococcus suis bacterin and subunit vaccine immunogenicities and protective efficacies against serotypes 2 and 9." Clin Vaccine Immunol 16 (2009): 200-208.

Google Scholar, Crossref

6. Segura, Mariela, Virginia Aragon, Susan L. Brockmeier and Connie Gebhart, et al. "Update on Streptococcus suis research and prevention in the era of antimicrobial restriction: 4th International Workshop on S. suis." Pathogens 9 (2020): 374.

Google Scholar, Crossref, Indexed at