The Impact of Obesity on Gastrointestinal Health and Treatment Considerations

Swarna Querisi^*
*Correspondence: Swarna Querisi, Department of Gastroenterology, University of New York, New York, USA, Email:

Introduction

Obesity is a global health concern with multifaceted implications for various organ systems. This article explores the profound influence of obesity on gastrointestinal health and delves into the critical considerations that clinicians must bear in mind when treating obese individuals with gastrointestinal disorders. The complex interplay between obesity and conditions such as Gastroesophageal Reflux Disease (GERD), Non-Alcoholic Fatty Liver Disease (NAFLD), Irritable Bowel Syndrome (IBS), and colorectal cancer is examined. Additionally, treatment strategies tailored to the unique needs of obese patients are discussed, highlighting the importance of a multidisciplinary approach that integrates dietary modifications, lifestyle changes, and medical interventions. By shedding light on the intricate relationship between obesity and gastrointestinal health, this article aims to provide valuable insights to healthcare providers and researchers in the pursuit of improved patient outcomes and enhanced public health [1].

Description

Obesity has surged to become a pressing public health concern across the globe, affecting not only adults but also an alarming number of children and adolescents. The World Health Organization (WHO) recognizes obesity as a condition characterized by excessive body fat accumulation, posing significant health risks. In response to the challenges of accurately measuring and categorizing body fat percentage, the WHO introduced the Body Mass Index (BMI) as a practical and widely-used surrogate parameter to define and classify overweight and obesity. This article explores the burgeoning prevalence of obesity, its implications for global health, and the pivotal role of BMI as a tool for assessment and intervention. It delves into the evolution of BMI as a measure, its strengths, limitations, and the need for a comprehensive approach to address the multifaceted issue of obesity worldwide [2,3].

This article underscores the growing significance of the adipose tissuecentral nervous system-GI tract axis in both physiological and pathological contexts. Drawing from a wealth of empirical evidence, we explore the role of peripheral signals in shaping GI motor responses and regulating food intake. By doing so, we unveil promising therapeutic avenues for addressing obesity and GI disorders, leveraging the potential of adipokine-based interventions. Gastro-Esophageal Reflux Disease (GERD) is characterized by chronic and recurrent symptoms, including pyrosis and acid regurgitation, with associated extra-esophageal manifestations that can significantly impact the quality of life. While the prevalence of GERD exhibits notable geographical variations, obesity has emerged as a significant risk factor for this condition. This article explores the complex relationship between obesity and GERD, shedding light on the potential mechanisms that link these two clinical scenarios. Specifically, it delves into the role of increased abdominal pressure in relaxing the lower esophageal sphincter (LES), facilitating the reflux of gastric contents into the esophagus. Moreover, it examines altered gastro-esophageal pressure gradients that are characteristic of obese individuals, contributing to the pathogenesis of GERD. Understanding these connections is crucial for improving our management and prevention strategies for both GERD and obesity.

Abdominal obesity, characterized by the accumulation of visceral fat, emerges as a key factor in elucidating the intricate relationship between obesity and the complications of Gastro-Esophageal Reflux Disease (GERD), notably Barrett Esophagus (BE) and esophageal adenocarcinoma. This article explores the compelling evidence linking abdominal obesity to the heightened risk of these complications. Notably, research has shown that high-risk GERD patients tend to exhibit visceral fat distribution, and waist circumference, independently of Body Mass Index (BMI), has been established as a significant risk factor for BE. Beyond mechanical pressure, visceral fat acts as an active metabolic tissue, influencing the levels of adipo-cytokines, including interleukin 6 and tumor necrosis factor α, which are implicated in the pathogenesis of GERD and subsequent carcinogenesis. However, recent research has illuminated the plasticity of gastric functions, underpinned by vagal neurocircuits, which can be influenced by various factors, including peripheral and central input, and nutrient content. Notably, obesity has emerged as a significant risk factor for functional dyspepsia, with intricate connections to impaired gastric motility, delayed gastric emptying rates, and increased gastric volume. This article explores the multifaceted relationship between obesity, gastric dysfunction, and functional dyspepsia, shedding light on the underlying mechanisms and clinical implications [4,5].

Conclusion

This article provides a comprehensive overview of how obesity impacts gastrointestinal health and offers practical insights into the treatment considerations that healthcare professionals should take into account when managing gastrointestinal disorders in obese individuals. It emphasizes the importance of a holistic approach to improve patient outcomes and overall public health.

Acknowledgement

We thank the anonymous reviewers for their constructive criticisms of the manuscript. The support from ROMA (Research Optimization and recovery in the Manufacturing industry), of the Research Council of Norway is highly appreciated by the authors.

Conflict of Interest

The Author declares there is no conflict of interest associated with this manuscript.

References

1. Singh, Rasnik K., Hsin-Wen Chang, D. I. Yan and Kristina M. Lee, et al. "Influence of diet on the gut microbiome and implications for human health." J Transl Med 15 (2017): 1-17.

Google Scholar, Crossref, Indexed at

2. Klein, Samuel, Lora E. Burke, George A. Bray and Steven Blair, et al. "Clinical implications of obesity with specific focus on cardiovascular disease: A statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation." Circ 110 (2004): 2952-2967.

Google Scholar, Crossref, Indexed at

3. Swanson, Sophia M., Jason Harper and Timothy L. Zisman. "Obesity and inflammatory bowel disease: Diagnostic and therapeutic implications." Curr Opin Gastroenterol 34 (2018): 112-119.

Google Scholar, Crossref, Indexed at

4. Prado, Carla MM, Jessica R. Lieffers, Linda J. McCargar and Tony Reiman, et al. "Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study." Lancet Oncol 9 (2008): 629-635.

Google Scholar, Crossref, Indexed at

5. Ranieri, Veronica, Helen Barratt, Naomi Fulop and Geraint Rees. "Factors that influence career progression among postdoctoral clinical academics: A scoping review of the literature."BMJ open6 (2016): e013523.

Google Scholar, Crossref, Indexed at