A facile strategy for the fabrication of three-dimensional nanofibrous scaffold

4^th International Conference and Exhibition on Materials Science & Engineering

September 14-16, 2015 Orlando, USA

Suresh Raj Pant1, Mahesh Kumar Joshi2, 3, Hem Raj Pant1, 2, Han Joo Kim3, Chan Hee Park3 and Cheol Sang Kim3

1Research Institute for Next Generation, Nepal 2Tribhuvan University, Nepal 3Chonbuk National University, Republic of Korea

Posters-Accepted Abstracts: J Material Sci Eng

Abstract :

One of the major concerns of scientific community with electrospun nanofibrous scaffolds is the densely packed fibers in 2-D array which impedes their applicability in tissue regeneration. To overcome these problems, a three-dimensional nanofibrous scaffold was fabricated using a noble gas foaming technique and studied for biomedical applications. In this novel approach, Polycaprolactone (PCL) nonwoven membrane was fabricated by electrospinning process and treated with Sodium Borohydride (SB) solution (0.1 M solution prepared in methanol) to modify into 3-D scaffold. We have purposed the mechanism for the fabrication of 3-D scaffold. As the PCL mat was put into the SB solution interconnected pores of a mat are filled with that solution driven by capillary forces where it undergoes hydrolysis to produce hydrogen gas. The in situ generated gas molecules form clusters to minimize the free energy resulting in pore nucleation that reorganizes the nanofibers to form a low density, macroporous, spongy and multi-layered 3-D scaffold. The scaffolds were characterized in terms of porosity, density and biocompatibility. Large pore size and multilayered structure of as fabricated scaffold improved the cell infiltration and growth compared to 2-D electrospun mat. This simple and facile process will reveal a new approach for the fabrication of a three-dimensional, low-density, nanofibrous materials for biomedical and industrial applications using a wide variety of polymers.

Biography :

Suresh Raj Pant has completed his Master’s degree from Chonbuk National University, Jeonju, South Korea. Presently, he is associated with Research Institute for Next Generation (RING) Nepal as a Research Associate.

Email: sureshpant_sp@yahoo.com pant.suresh88@gmail.com