A pharmacological update of nephrotoxic drugs

3^rd World Kidney Congress

October 08-10, 2018 Dubai, UAE

Tasneem Sandozi

Dubai Medical College, UAE

Scientific Tracks Abstracts: J Nephrol Ther

Abstract :

Tetracyclines & Glycylcyclines: Tetracycline, Oxytetracycline,Minocycline,Doxycycline,Tigecycline The catabolic effect of tetracyclines aggravates azotemia in patients with renal disease Fanconi syndrome: Outdated tetracyclines cause toxic effects on proximal renal tubules Amphotericin B: It is a broad spectrum antifungal drug having the broadest spectrum of activity Formulations: Four formulations available to make it suitable for intravenous administration as it is insoluble in water C-AMB: Amphotericin B is formulated with bile salt deoxychole Amphotericin B colloidal dispersion (ABCD),It contains equal amounts of amphotericin B and cholesteryl sulphate, Liposomal Amphotericin B (L-AMB),Amphotericin B is incorporated within unilamellar,liposomal vesicle formulation,Amphotericin B lipid (ABLC) It complex is a complex of two phospholipids Nephrotoxicity of AMP-B formulations Serum creatinine doubles by 57% during therapy Except C-AMB all three reduce risk of active kidney disease: Azotemia occurs in 80% of patients who receive C-AMB for deep mycosis ABLC has been observed to be more nephrotoxic than L-AMP-B in patients at high risk for nephrotoxicity Nephrotoxicity of AMP-B formulations: Serum creatinine doubles by 57% during therapy Lipid formulations decrease nephrotoxicity Except C-AMB all three reduce risk of active kidney disease Azotemia occurs in 80% of patients who receive C-AMB for deep mycosis ABLC has been observed to be more nephrotoxic than L-AMP-B in patients at high risk for nephrotoxicity In adults with normal renal function prior to treatment permanent functional impairment is uncommon even though permanent histological changes occur during short courses of C-AMB: Renal tubular acidosis & renal wasting of potassium & magnesium may also be seen several weeks after therapy Supplemental potassium is required in 1/3rd of the patients on prolonged therapy

Biography :

Tasneem Sandozi is a Diplomate of National Board (DNB) Internal Medicine. She is a Journal Reviewer for International Journal of Diabetes in Developing Nations, International Research Journal of Medicine and Biomedical Sciences and a Life Member of Indian Pharmacological Society.

E-mail: tasneemsandozi@yahoo.com