Adverse childhood experiences as the background of many hepatic and gastrointestinal and other disorders

2^nd International Conference on Hepatitis

June 14, 2021 | Webinar

Mihaly Makara

Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Saint Laszlo Hospital

Scientific Tracks Abstracts: Hepatol Pancreat Sci

Abstract :

Background and Aims: Adverse childhood experiences (ACEs) are associated with many kinds of addictions, risk behaviors, psychological and mental disorders, and many leading causes of death. Our aim was to investigate the prevalence of ACEs among patients suffering from various liver diseases. Method: We used the WHO international questionnaire (ACE-IQ) and additional questions about addictions, suicide attempts, education, and employed various psychological tests. We counted the serious adverse experiences according to the recommendation of WHO. Results: 644 tests were analyzed: 212 addicted patients (69 formal iv. drug users with hepatitis, 11 people with alcoholic liver diseases, 85 people who were undergoing treatment at the National Institute of Psychiatry and Addiction and 47 people who were undergoing treatment at an addiction treatment foundation and 432 control subjects (for example 21 patients with transfusion acquired hepatitis C, 114 university students, 50 job seeker, 57 people who went to see their doctor to renew their license, etc.). The average of ACEs was 2.5 among controls, while 4.4 among addicted patients (2.4 among patients with alcoholic liver disorders, 4.9 in the group of iv. drug users and 4.2 among other addicted patients). There were 91 people who gave no positive answers to serious adverse childhood experiences. Only 11 (12%) of them were from the addicted group, only one of them (1%) had a suicide attempt, and 26 (28.6%) of them had an university degree. With rising ACE counts the percentage of addicted patients and the number of people with suicide attempts were raising in a graded fashion, while the percentage of people with high level education decreased. There were 121 people who had 6 or more severe ACEs, 69 (57%) of them were from the addicted group, 51 (42.1%) of them had a suicide attempt, and 19 (15.7%) of them had an university degree. In many gastrointestinal diseases symptoms are rising according to the number of ACEs including frequent vomiting, diarrhea, and diarrhea alternating with constipation. We examined 8 patients with non-alcoholic fatty liver disease (NAFLD) and obesity (BMI > 35) also. Their ACE count average was 2.6. The study is ongoing.Conclusion: High scores of ACEs are found in addicted patients and especially high in iv. addicts. Many gastrointestinal symptoms are also correlated with ACEs.