Aldose reductase inhibition of valeriana fauriei

3^rd International Conference and Exhibition on Traditional & Alternative Medicine

August 03-05, 2015 Birmingham, UK

Jaemin Lee1, Sang-Won Lee2, Young-Ock Kim2, Chun-Geun Park2, Young-Seob Ahn2, Hak_Jae_Kimâ�? Hak-Jae Kim3, Ik-Hyun Cho4 and Sanghyun Lee1

1Chung-Ang University, Republic of Korea 2NIHHS, RDA, Republic of Korea 3Soonchunhyang University, Republic of Korea 4Kyung Hee University, Republic of Korea

Posters-Accepted Abstracts: Altern Integr Med

Abstract :

To evaluate therapeutic potentials of aldose reductase (AR) inhibition, the rhizomes of Valeriana fauriei were tested for inhibition of AR. The EtOH extracts of V. fauriei were exhibited AR inhibition. Additionally, the stepwise polarity fractions of V. fauriei were exhibited AR inhibition on rat lens. Of these, the ethyl acetate (EtOAc) fraction was showed highest AR inhibition with IC50 value of 1.86 �?¼g/ml. In this result, we demonstrate that V. fauriei could be a useful natural source and development of a new AR inhibitory agent against diabetic complications.

Biography :

Email: slee@cau.ac.kr