Aldose reductase inhibitors from Perilla frutescens var. japonica

3^rd International Conference and Exhibition on Traditional & Alternative Medicine

August 03-05, 2015 Birmingham, UK

Jaemin Lee1, Jeong Min Lee2, Myoung-Hee Lee2, Ki Won Oh2, Eun Ju Cho3 and Sanghyun Lee1

1Chung-Ang University, Republic of Korea 2National Institute of Crop Science, Republic of Korea 3Pusan National University, Republic of Korea

Posters-Accepted Abstracts: Altern Integr Med

Abstract :

To investigate the therapeutic activities of compounds from natural plant source, the seeds of Perilla frutescens var. japonica were tested for inhibition of aldose reductase inhibition (ARI). The EtOH extracts of P. frutescens var. japonica were tested ARI. Additionally, stepwise polarity fractions and compounds from P. frutescens var. japonica were exhibited ARI. The compounds were identified as luteolin (1), apigenin (2), diosmetin (3), kaempferol (4), �²-sitosterol (5), and daucosterol (6) by NMR. As a result, the EtOAc fraction and flavonoids (compounds 1-4) showed good ARI. Our results expect that the seeds of P. frutescens var. japonica could be useful and helpful ARI materials against various diabetic complications.

Biography :

Jaemin Lee is a graduate student at Chung-Ang University, Republic of Korea.

Email: slee@cau.ac.kr