Allele Frequency of HLA-B Database in 4 Regions of Thailand

Joint Event on 11^th World GLYCOBIOLOGY CONGRESS & 14^th International Conference on GENOMICS AND MOLECULAR BIOLOGY

May 17-18, 2021 WEBINAR

Cindy Shainwald and Patompong Satapornpong

Maryvit Sattahip School, Thailand
Patompong Satapornpong, Ph.D., College of Pharmacy, Rangsit University, Thailand

Scientific Tracks Abstracts: J Clin Med Genomics

Abstract :

Statement of the Problem: HLA plays a significant role in our immune system and is directed by genes on the 6th chromosome. In previous studies, we found the distribution of HLA-B alleles that has an association with pharmacogenetics markers in different ethnic groups. The aim of this study is to explore the distribution of HLA-B alleles in 4 regions of Thailand Methodology & Theoretical Orientation: Unrelated 200 healthy Thai population were collected for HLA-B genes. HLA-B genotyping was carried out using the polymerase chain reaction-sequence specific oligonucleotides probe system (PCR-SSO) Findings: The most commonly HLA-B allele found in Thailand was HLA-B* 46:01 consists of Northern (19%), Central (21%), Northeastern (16%) whereas, HLA-B* 15:02 was the most frequent allele in Southern of Thailand. This study found that 5% of Northern, 10% of Central and 8% of Northeastern Thai subjects carries HLA-B*15:02 allele which has been related with carbamazepine-induced severe cutaneous adverse drug reactions (SCARs). Furthermore, Northern, Central, Northeastern and Southern healthy Thai subjects carry HLA-B*13:01 allele was 7%, 9%, 4% and 5%, respectively. HLA-B* 13:01 was strongly associated with dapsone-induced SCARs in Asians. The frequency of HLA-B* 58:01 was 4% of Northern, 7% of Central, 11% of Northeastern and 4% of Southern, which associated with allopurinol-induced SCARs. Conclusion & Significance: When compared HLA-B alleles frequency from 4 regions of Thailand, we found similar HLA-B distribution among Northern, Central and Northeastern except Southern. Consequently, the frequency of HLA-B gene database in 4 regions of Thailand influenced on pharmacogenetics markers distribution and contributes to screening tests before initiating treatment in Thai population.

Biography :

Cindy Shainwald is currently studying in senior year in high school at Maryvit Sattahip Schoolin Thailand. She has always been fascinatedwith science and the components of the human body. Her goal is to pursue a medical degree and become a doctor in the near future. In order to obtain experiences, explore answers and build a better understanding of medicalprocedures, She has participated in this research project which involves collecting HLA-B Database from individuals DNA through different lab processes to gain a greater perception on HLA-B alleles that has an association with pharmacogenetics markers and the significance of undergoing the medical model of precision medicine in Thai population.