Agata W Dzeljilji
National Tuberculosis and Lung Diseases Research Institute, Poland
Scientific Tracks Abstracts: J Cardiovasc Dis Diagn
Alpha-1-antitrypsin is a potent antiprotease playing an important role in maintaining protease-antiprotease balance. It protects the structures of extracellular matrix against destruction by proteolytic enzymes. Loss of elasticity occurs when increased protease activity is accompanied by qualitative impairment or reduced con- centrations of antiproteases. Alpha-1-antitrypsin de ciency is a risk factor for obstructive lung disease, including emphysema, liver and kidney disorders and, less often, follicular panniculitis, granulomatosis with polyangiitis (previously Wegenerâ??s granulomatosis). Literature also emphasises the role of AAT in the development of aortic aneurysms, and results of biochemical studies support this theory. Aortic aneurysm is an important clinical problem, unceasingly associated with high mortality. For this reason, it is exceptionally important to identify its risk factors. Studies on the relationship between AAT and development of AAA (abdominal aortic aneurysm) have been conducted since the 1990s. Due to the development in molecular diagnostic techniques, new reports on the topic appeared over the last decade.
Agata W Dżeljilji is a practicing surgeon at the Institute of Tuberculosis and Lung Disease in Warsaw, where she is studying management of thoracic disease. She conducts research in pulmonology and vascular surgery. Her main clinical intrests are metabolic aspects of elastin and collagen fibers proteolysis in the diseases of the respiratory and vascular system, and the significance of alpha-1 antitrypsin deficiency. Her most recent publication is 'The role of alpha-1-antitrypsin protein in the pathogenesis of aortic aneurysm'. She is also a reviewer for JTD.
E-mail: nosearmy85@gmail.com
Cardiovascular Diseases & Diagnosis received 427 citations as per Google Scholar report
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