An approach to enhance dissolution rate and bioavailability by spray drying with silica

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Dhanashri S. Yadav

Posters: Pharmaceut Reg Affairs

Abstract :

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. Spray drying is an efficient technology for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an APIcarrier solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid dispersions, but also other factors like the interplay between the API, carrier and solvent, solution state of the API, formulation parameters (e.g. feed concentration or solvent type) and process parameters (e.g. drying gas flow rate or solution spray rate) will influence the final physical structure of the obtained solid dispersion particles. The present study was carried out by using silica adsorbents such as aerosil 200,sylysia 350 as carrier for solid dispersion preparation by spray drying technique. The conversion of crystalline form of poorly water soluble API into amorphous form in silica based carrier results into enhanced dissolution rate and bioavailability.

Biography :

Dhanashri Yadav, doing M. Pharm. (Pharmaceutics) at Shivaji University, Kolhapur. She has presented various posters in national conferences and has published two research articles in international journals. She is a Life Member of Indian Pharmaceutical Association.