Analgesic activity of some new 1,4-dihydropyridine derivatives

2^nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing

October 15-17, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

R. Surendrakumar and A. Idhayadhulla

Accepted Abstracts: Med chem

Abstract :

1,4-dihydropyridine derivatives display a broad spectrum of medicinal activities, mainly analgesic activity . The present investigation involves synthesis of novel 1,4-dihydropyridine derivatives (2a-2g) by the amination method. The synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR, mass spectra and mass spectral fragmentation. The reaction was performed by using ordinary condensation type, which enabled to easy work-up and good yield. The synthesized compounds were carried out for analgesic activity. Compounds (2a-2g) were screened for analgesic activity. Our results demonstrate compound 2b is moderate active (60 min) at dose (10 mg/ kg) against standard and the compound 2c is highly active (60 min) at dose (10 mg/ kg), other compounds are less active compared with standard. Pentagocine was used as a standard.