Analysis of the risk factors and clinical features of Mycoplasma pneumoniae pneumonia with embolism in children: A retrospective study

6^th World Pediatrics Conference

October 07, 2022 | Webinar

Wei Guo , Chunjiao Han

Tianjin Childrenâ??s Hospital ,Tianjin University Childrenâ??s Hospital, China

Scientific Tracks Abstracts: J Pediatr Neurol Med

Abstract :

Mycoplasma pneumoniae pneumonia is common in the community-acquired pneumonia in children. However, in addition to respiratory manifestations, it may also develop extra-pulmonary complications. Embolism is one of the uncommon extra-respiratory manifestations which has been reported in previous study. If not diagnosed and treated in time, it is prone to serious sequelae and even life-threatening. In this study, we retrospectively analysed and compared basic information, clinical manifestations and imaging results between 16 children in MPP with embolism and 32 children with MPP who had a clinical suspicion of embolism but negative radiological results. Conclusion & Significance: In our study, the average diagnosis time of pulmonary embolism, cardiac embolism, cerebral embolism, splenic embolism and limb embolism were 13.4 days, 8.7 days, 15 days, 14 days and 10 days. All children with pulmonary embolism had fever and cough. Two children (10%) presented shortness of breath and three children (30%) developed pain in different part of the body. Only one children developed dyspnea and no children had hemoptysis. The children with cardiac embolism not only had shortness of breath, but also developed hypoxemia and neck pain. Children with cerebral embolism may present symptoms of neurological symptoms such as disorder of consciousness and weakness of unilateral limb. Limb weakness occurred in 3 children (100%) with cerebral embolism and one of them had positive pathological signs and dyspnea respectively. Children with splenic embolism presented with left upper abdomen and periumbilical abdominal pain with vomiting. We conducted a case-control study and the results in this study showed that children with embolism caused by MPP have higher D-dimer level and severe imaging findings. D-dimer (closest to CTA/MRA) > 3.55 mg/L, pulmonary consolidation (⩾ 2/3 lobe) and pleural effusion were independent risk factors for embolism in children with MPP. Early diagnosis and anticoagulant therapy can effectively reduce complications and mortality.

Biography :

Dr. Guo has been engaged in pediatric clinical and scientific research for 16 years. Since 2009, he has mastered the technology of children’s bronchoscopy and completed the diagnosis and treatment of the first case of plastic bronchitis in children in Tianjin. Nearly 10000 children’s bronchoscopy operations have been completed, and they are skilled in the diagnosis and treatment of PB. It took the lead in using tissue enzyme activator to treat children with PB in China and achieved good results.