Anti-inflammatory chemical constituents of Cordyceps militaris

2^nd International Conference and Exhibition on Metabolomics & Systems Biology

April 08-10, 2013 Hilton Chicago/Northbrook, USA

Hyung Jun Noh, Juyoung Yoon, Geum Sook Kim, Seung Eun Lee, Dae Young Lee, Je Hun Choi, Seung Yu Kim, Hyun Bong Park, Kang Ro Lee and Jae Youl Cho

Posters: Metabolomics

Abstract :

Cordyceps militaris (Clavicipitales) is an edible mushroom which is widely distributed in China, Japan and Korea. Various phytochemical constituents, cordycepin, homocitrullylaminoadenosine and sterols have been reported from this source and a wide range of biological activities, including antimicrobial, macrophage activation, anticancer, immune modulatory effects were studied. In a continuing search for bioactive constituents from Korean mushrooms, we performed a phytochemical investigation of the MeOH extract from the fruiting bodies of C. militaris . By repeated column chromatographic separation of the extract, fourteen compounds were isolated. The identification and structural elucidation of the compound was based on NMR spectral data. The NF-kB mediated luciferase activities were performed for measuring their immunomodulatory roles