Anti-inflammatory effect of methanolic extract of root of Dorema glabrum in carrageenan test in mice

8^th World congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit

June 26-27, 2017 San Diego, USA

Azam Bakhtiarian and Vahid Nikoui

Tehran University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Bioanal Biomed

Abstract :

Anti-inflammatory potentials of methanolic extract of root of Dorema glabrum was evaluated against different animal models in rodents. Anti-inflammatory effects of Dorema glabrum was assessed in rat using the carrageenan test. Antiinflammatory effects of Dorema glabrum in three different doses, namely, 50 mg/kg, 100 mg/kg and 200 mg/kg were evaluated by utilizing different animal models representing various changes associated with inflammation, namely, carrageenaninduced paw edema. Also Dorema glabrum was phytochemically evaluated using chromatographic method. The Dorema glabrum did not exhibit any signs of toxicity up to a dose of 200 mg/kg. The extract showed statistical significant inhibition of induced inflammation in dose dependent manner. The higher dose of extract significantly inhibited inflammation against control (P<0.05). The present study scientifically demonstrated the anti-inflammatory potential of roots of Dorema glabrum methanolic extract. These effects may be attributed to the presence of polyphenolic phytoconstituents in the extract.

Biography :

Azam Bakhtiarian is an Associate Professor in the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences. She has received her PhD in Pharmacology from University of California, Irvine, USA. She is working in the field of pharmacology and toxicology looking at different aspects of drugs action both in-vivo and in-vitro.

Email: bakhtiar12@yahoo.com