Anti-metastatic activity of Albizia lebbeck stem bark extract against breast cancer cell lines

Joint Event on 2^nd International Conference on Cancer Biology, Therapeutics and Drug Discovery and Delivery & 10^th Annual Congress on Biomarkers, Clinical Research & Therapeutics

October 03-04, 2018 | Los Angeles, USA

Huzaifa Umar and Nahit Rizaner

Cyprus International University, Turkey.

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Breast cancer is the most usual cancer type and second most frequent cause of death among women worldwide. The incidence of breast cancer is still increasing because of irresponsive treatments. Albizia lebbeck is an important plant with medicinal properties and cultivated in different part of the world mainly the tropical and subtropical regions. Cytoxicity, anti-proliferation and antimetastatic potential of A. lebbeck methanolic extract was studied in MDA-MB 231 and MCF-7 cell models using tryphan blue, MTT and wound heal assay and organic composition of the plant was analyzed using gas chromatography-mass spectrometry (GC-MS). Both cells were treated with different concentrations ranging from 2.5 to 200 μg/mL and different incubation periods (24, 48 and 72 hours). Cytotoxicty and anti-proliferative effect of the extract on MDA-MB 231 and MCF-7 cell were found to be both concentration and time dependent. Lower concentration of the extract 2.5, 5.0 and 10.0 μg/mL showed no effect on cytotoxicity and proliferation of the cell lines and higher concentrations revealed significant effect with increasing concentrations when compared with the control group. The plant extract also revealed high anti-metastatic effect which is found to be concentration dependent as well. Important bioactive compounds were also identified from A. lebbeck metanolic extract, which might be responsible for anti-metastatic potential of the plant and it could be a promising tool for prevention of cancer metastasis.

Biography :

E-mail: huzaifee27@gmail.com